Title: Visit Mesopotamia: Best of Mesopotamia Tourism | Expedia Travel Guide - Expedia.com [Hotels in Mesopotamia](https://expedia.com/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.com/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.com/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Car Rentals in Mesopotamia](https://expedia.com/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)[Mesopotamia Vacation Packages](https://expedia.com/Mesopotamia.d6208836.Destination-Travel-Guides) # Mesopotamia ## Travel Guide ![Mesopotamia showing a river or creek and forest scenes](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia featuring forest scenes](https://images.trvl-media.com/place/180997/7a653d94-20a1-43a0-b303-6577a8217222.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Foz do Iguaçu which includes bird life](https://images.trvl-media.com/place/180997/ae7673a2-dfbe-430a-b060-de1d51d3af44.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia featuring forest scenes and a river or creek](https://images.trvl-media.com/place/6208836/589ecd67-e516-45e9-9448-7351cf47baac.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia featuring a cascade and a river or creek](https://images.trvl-media.com/place/6208836/5a8ac315-270d-4341-93a1-6d04d66106c9.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Mesopotamia Things to do #### The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration. A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos. Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú. Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting. Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve. Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into color in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park. The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organized tours. - Mesopotamia Hotel Deals - Vacation Rentals in Mesopotamia ![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### O2 Hotel Gualeguaychú 115 3 de Febrero Gualeguaychú Entre Ríos $46 nightly $46 total Mar 23 - Mar 24 Stay at this hotel in Gualeguaychú. Enjoy free WiFi, a 24-hour front desk, and a business center. Popular attractions Gualeguaychú Cathedral and San Martin Square ... 7.8/10 Good! (78 reviews) Si un huesped pregunta si se olvida algo en la habitacion tener la deliquicadesa de contestar por eso la calificaccion no me volveria a quedar Reviewed on Dec 23, 2025 [](https://expedia.com/Hotel-Search?startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&selected=76459363&PinnedHotelID=76459363&HadPinnedHotel=true®ionId=6208836) ![Turismo Hotel Casino](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/a0b30be4_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Turismo Hotel Casino 650 Entre Ríos Corrientes Corrientes $111 nightly $111 total Mar 24 - Mar 25 Stay at this hotel in Corrientes. Enjoy free breakfast, free WiFi, and 2 restaurants. Popular attractions Cumba Cua Park and Casinos del Litoral are located ... 8/10 Very Good! (4 reviews) Boa infraestrutura, e localização! Reviewed on Feb 4, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F24%2F2026&endDate=3%2F25%2F2026&selected=120517502&PinnedHotelID=120517502&HadPinnedHotel=true®ionId=6208836) ![Complejo La Loma](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/11027249_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Complejo La Loma Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos $40 nightly $40 total Mar 26 - Mar 27 Stay at this aparthotel in Federacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Termas Federacion Water Park and Termas de Federacion ... 8/10 Very Good! (5 reviews) Great self-contained suite! Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ... Reviewed on Sep 9, 2023 [](https://expedia.com/Hotel-Search?startDate=3%2F26%2F2026&endDate=3%2F27%2F2026&selected=88087470&PinnedHotelID=88087470&HadPinnedHotel=true®ionId=6208836) [See all 514 properties in Mesopotamia](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F20%2F2026&endDate=3%2F21%2F2026®ionId=6208836) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Complejo La Loma](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/11027249_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Complejo La Loma Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos Stay at this aparthotel in Federacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Termas Federacion Water Park and Termas de Federacion ... 8/10 Very Good! (5 reviews) Great self-contained suite! Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ... Reviewed on Sep 9, 2023 [](https://expedia.com/Federacion-Hotels-Complejo-La-Loma.h88087470.Hotel-Information) ![Donsuites Apart Hotel](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/fb045420_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Donsuites Apart Hotel La Rioja 442 Corrientes Corrientes Stay at this aparthotel in Corrientes. Enjoy free breakfast, free WiFi, and a rooftop terrace. Popular attractions Museo de Artesanías Tradicionales Folclóricas ... [](https://expedia.com/Corrientes-Hotels-Donsuites-Apart-Hotel.h4947848.Hotel-Information) ![Totoras Apart Federacion](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/8a2a257a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Totoras Apart Federacion Ñandubay (ex Hermanas Betancourt) 2610 Federacion Entre Rios Stay at this aparthotel in Federacion. Enjoy free WiFi, free parking, and room service. Popular attractions Termas de Federacion and Termas Federacion Water ... [](https://expedia.com/Federacion-Hotels-Totoras-Apart-Federacion.h33341429.Hotel-Information) [See all properties in Mesopotamia](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6208836&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Mesopotamia hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-03-19&endDate=2026-03-20)[Mar 19 - Mar 20](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-03-19&endDate=2026-03-20) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-03-20&endDate=2026-03-21)[Mar 20 - Mar 21](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-03-20&endDate=2026-03-21) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)[Mar 20 - Mar 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026)[Mar 27 - Mar 29](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026) ### Popular places to visit ![Parque Nacional El Palmar, Entre Rios, Argentina.](https://images.trvl-media.com/place/6096826/3ac30eef-b699-482d-95ce-e991c872d599.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### El Palmar National Park Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. [](https://expedia.com/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction) ![Punta San Sebastian, Corrientes, Costanera Corrientes](https://images.trvl-media.com/place/553248621532463961/5eccf4f4-bdb0-4368-8beb-0fffd1c8eab0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Costanera de Corrientes 4/5(2 reviews) Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area. [](https://expedia.com/Costanera-De-Corrientes-Corrientes.d553248621532463961.Vacation-Attraction) ![Parroquia Nuestra Señora de Itati](https://images.trvl-media.com/place/553248621532463967/dcc3f703-5a3b-46d8-99a7-83b2e87b8ea0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Basilica Nuestra Senora De Itati Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. [](https://expedia.com/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Vacation-Attraction) ![La Cocina ](https://images.trvl-media.com/place/553248635974793605/0fefc8ed-f808-424a-94c4-7db511b97bd3.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San José Palace You can spend an afternoon exploring the galleries in San José Palace in Caseros. [](https://expedia.com/San-Jose-Palace-Caseros.d553248635974793605.Vacation-Attraction) #### Termas de Federacion Bring your family to Termas de Federacion and have a fun-filled day at this amusement park in Federacion. Stroll along the beaches or discover the area's waterfalls. [](https://expedia.com/Termas-De-Federacion-Federacion.d553248621532463682.Vacation-Attraction) #### Isla Cambacua Beach Why not spend a lazy afternoon at Isla Cambacua Beach during your trip to Concepción del Uruguay? Experience the area's art scene and museums. [](https://expedia.com/Isla-Cambacua-Beach-Concepcion-del-Uruguay.d553248635974793609.Vacation-Attraction) ## Cities near Mesopotamia ![A view of the Costanera (Park by the Uruguay river) in Paso de los Libres, Argentina - the Brazilian city of Uruguaiana is seen in the background](https://images.trvl-media.com/place/397/6e7a89b1-35ec-4907-be62-f8aa32e06629.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Paso de los Libres ![Carpincho](https://images.trvl-media.com/place/892/473e6065-5cc5-43d8-8bed-7d5ace2c2904.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Concordia ![Rock formation "El Arco" at Lake Posadas, Argentina](https://images.trvl-media.com/place/2887/d836a022-182c-4be3-ade6-4b3bb9158f9d.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Posadas ![Adobe](https://images.trvl-media.com/place/3026/594454f8-3526-4642-9a20-13c59381f9fd.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Rosario - Cities near Mesopotamia - Places of interest [Paso de los Libres](https://expedia.com/Paso-De-Los-Libres.dx397)[Concordia](https://expedia.com/Concordia.dx892)[Paysandu](https://expedia.com/Paysandu.dx2758)[Posadas](https://expedia.com/Posadas.dx2887)[Rosario](https://expedia.com/Rosario.dx3026)[Santa Fe](https://expedia.com/Santa-Fe.dx3131)[Uruguaiana](https://expedia.com/Uruguaiana.dx3648)[Bella Vista](https://expedia.com/Bella-Vista.dx178069)[Parana](https://expedia.com/Parana.dx500197)[Carmelo](https://expedia.com/Carmelo.dx602813)[Campana](https://expedia.com/Campana.dx6034204)[Esquina](https://expedia.com/Esquina.dx6049079)[Ituzaingo](https://expedia.com/Ituzaingo.dx6049974)[Paso de la Patria](https://expedia.com/Paso-De-La-Patria.dx6050259)[Empedrado](https://expedia.com/Empedrado.dx6050260)[San Pedro](https://expedia.com/San-Pedro.dx6054166)[Corrientes](https://expedia.com/Corrientes.dx6054203)[Fray Bentos](https://expedia.com/Fray-Bentos.dx6085046)[Ramallo](https://expedia.com/Ramallo.dx6123950)[San Nicolas de los Arroyos](https://expedia.com/San-Nicolas-De-Los-Arroyos.dx6126774)[Federacion](https://expedia.com/Federacion.dx6141108)[Colon](https://expedia.com/Colon.dx6144191)[Cayasta](https://expedia.com/Cayasta.dx6146247)[Gualeguaychú](https://expedia.com/Gualeguaychu.dx6201387)[San Salvador](https://expedia.com/San-Salvador.dx6201389) - [Termas de Federacion ](https://expedia.com/Termas-De-Federacion-Federacion.d553248621532463682.Vacation-Attraction) - [Costanera de Corrientes ](https://expedia.com/Costanera-De-Corrientes-Corrientes.d553248621532463961.Vacation-Attraction) - [El Palmar National Park ](https://expedia.com/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction) - [Isla Cambacua Beach ](https://expedia.com/Isla-Cambacua-Beach-Concepcion-del-Uruguay.d553248635974793609.Vacation-Attraction) - [Basilica Nuestra Senora De Itati ](https://expedia.com/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Vacation-Attraction) - [Termas Concepcion Entrerios ](https://expedia.com/Termas-Concepcion-Entrerios-Concepcion-del-Uruguay.d553248621532463656.Vacation-Attraction) - [Corsódromo ](https://expedia.com/Corsodromo-Gualeguaychu.d553248621532374259.Vacation-Attraction) - [Portal Carambola ](https://expedia.com/Portal-Carambola-Concepcion.d553248635998020259.Vacation-Attraction) - [Termas de Chajarí ](https://expedia.com/Termas-De-Chajari-Chajari.d553248621532463686.Vacation-Attraction) - [Termas Del Ayui ](https://expedia.com/Termas-Del-Ayui-Concordia.d553248621532463677.Vacation-Attraction) - [Concordia Speedway ](https://expedia.com/Concordia-Speedway-Concordia.d6266695.Vacation-Attraction) - [San José Palace ](https://expedia.com/San-Jose-Palace-Caseros.d553248635974793605.Vacation-Attraction) - [Termas de Guaychu ](https://expedia.com/Termas-De-Guaychu-Entre-Rios-Province.d553248621532463653.Vacation-Attraction) - [Lago de Salto Grande ](https://expedia.com/Lago-De-Salto-Grande-South-America.d553248621532463678.Vacation-Attraction) - [Victoria Beach ](https://expedia.com/Victoria-Beach-Victoria.d6250473.Vacation-Attraction) - [3 de Feberero Municipal Theater ](https://expedia.com/3-De-Feberero-Municipal-Theater-Parana.d553248621562511935.Vacation-Attraction) - [Physical Education Center No 3 ](https://expedia.com/Physical-Education-Center-No-3-Concepcion-del-Uruguay.d820428155927654400.Vacation-Attraction) - [Bodega Vulliez Sermet ](https://expedia.com/Bodega-Vulliez-Sermet-Colon.d553248621532463666.Vacation-Attraction) - [Velissa Spa Termal ](https://expedia.com/Velissa-Spa-Termal-Villa-Elisa.d553248621532463662.Vacation-Attraction) - [Pelicano Beach ](https://expedia.com/Pelicano-Beach-Paso-de-la-Patria.d553248621561119299.Vacation-Attraction) - [Church of St. Justo and Pastor ](https://expedia.com/Church-Of-St-Justo-And-Pastor-Colon.d6319241.Vacation-Attraction) - [Concordia Golf Course ](https://expedia.com/Concordia-Golf-Course-Concordia.d6266691.Vacation-Attraction) - [Pascual Toso Winery ](https://expedia.com/Pascual-Toso-Winery-San-Jose.d553248621532463420.Vacation-Attraction)