Title: Visit Mesopotamia: Best of Mesopotamia Tourism | Expedia Travel Guide - Expedia.com [Hotels in Mesopotamia](https://expedia.com/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.com/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.com/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Car Rentals in Mesopotamia](https://expedia.com/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)[Mesopotamia Vacation Packages](https://expedia.com/Mesopotamia.d6208836.Destination-Travel-Guides) # Mesopotamia ## Travel Guide ![Mesopotamia](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia](https://images.trvl-media.com/place/180997/7a653d94-20a1-43a0-b303-6577a8217222.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia](https://images.trvl-media.com/place/180997/ae7673a2-dfbe-430a-b060-de1d51d3af44.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia](https://images.trvl-media.com/place/6208836/589ecd67-e516-45e9-9448-7351cf47baac.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia](https://images.trvl-media.com/place/6208836/5a8ac315-270d-4341-93a1-6d04d66106c9.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Mesopotamia Things to do #### The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration. A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos. Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú. Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting. Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve. Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into color in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park. The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organized tours. - Mesopotamia Hotel Deals - Vacation Rentals in Mesopotamia ![Marriott Corrientes Hotel](https://images.trvl-media.com/lodging/118000000/117160000/117154200/117154160/45830686_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Marriott Corrientes Hotel Av Costanera Juan Pablo II y Lavalle Corrientes $116 nightly $116 total Apr 12 - Apr 13 Book a stay at this luxury hotel in Corrientes. Enjoy a steam room. Popular attractions Costanera de Corrientes and Cumba Cua Park are located nearby. 10/10 Exceptional! (24 reviews) I had a great experience at this Marriott hotel in Corrientes. The property is exactly as described — beautiful, well-maintained, and with an excellent location. I stayed there for a wedding, and everything was outstanding. The service was incredible from start to finish, and the staff was always ... Reviewed on Mar 24, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=117154160&PinnedHotelID=117154160&HadPinnedHotel=true®ionId=6208836) ![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### O2 Hotel Gualeguaychú 115 3 de Febrero Gualeguaychú Entre Ríos $50 nightly $50 total Apr 5 - Apr 6 Stay at this hotel in Gualeguaychú. Enjoy free WiFi, a 24-hour front desk, and a business center. Popular attractions Gualeguaychú Cathedral and San Martin Square ... 7.6/10 Good! (80 reviews) Las sabanas estaban sucias No andaba la tele para ver No salía agua caliente y el desayuno horrible Reviewed on Mar 20, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=76459363&PinnedHotelID=76459363&HadPinnedHotel=true®ionId=6208836) ![Turismo Hotel Casino](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/a0b30be4_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Turismo Hotel Casino 650 Entre Ríos Corrientes Corrientes $103 nightly $103 total Apr 19 - Apr 20 Stay at this hotel in Corrientes. Enjoy free breakfast, free WiFi, and 2 restaurants. Popular attractions Cumba Cua Park and Casinos del Litoral are located ... 8/10 Very Good! (4 reviews) Boa infraestrutura, e localização! Reviewed on Feb 4, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F19%2F2026&endDate=4%2F20%2F2026&selected=120517502&PinnedHotelID=120517502&HadPinnedHotel=true®ionId=6208836) [See all 507 properties in Mesopotamia](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=4%2F3%2F2026&endDate=4%2F4%2F2026®ionId=6208836) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Complejo La Loma](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/11027249_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Complejo La Loma Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos Stay at this aparthotel in Federacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Termas Federacion Water Park and Termas de Federacion ... 8.4/10 Very Good! (6 reviews) Great self-contained suite! Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ... Reviewed on Sep 9, 2023 [](https://expedia.com/Federacion-Hotels-Complejo-La-Loma.h88087470.Hotel-Information) ![Totoras Apart Federacion](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/8a2a257a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Totoras Apart Federacion Ñandubay (ex Hermanas Betancourt) 2610 Federacion Entre Rios Stay at this aparthotel in Federacion. Enjoy free WiFi, free parking, and room service. Popular attractions Termas de Federacion and Termas Federacion Water ... [](https://expedia.com/Federacion-Hotels-Totoras-Apart-Federacion.h33341429.Hotel-Information) ![Donsuites Apart Hotel](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/fb045420_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Donsuites Apart Hotel La Rioja 442 Corrientes Corrientes Stay at this aparthotel in Corrientes. Enjoy free breakfast, free WiFi, and a rooftop terrace. Popular attractions Museo de Artesanías Tradicionales Folclóricas ... [](https://expedia.com/Corrientes-Hotels-Donsuites-Apart-Hotel.h4947848.Hotel-Information) [See all properties in Mesopotamia](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6208836&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Mesopotamia hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-04-02&endDate=2026-04-03)[Apr 2 - Apr 3](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-04-02&endDate=2026-04-03) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-04-03&endDate=2026-04-04)[Apr 3 - Apr 4](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-04-03&endDate=2026-04-04) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026)[Apr 3 - Apr 5](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026)[Apr 10 - Apr 12](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026) ### Popular places to visit ![Parque Nacional El Palmar, Entre Rios, Argentina.](https://images.trvl-media.com/place/6096826/3ac30eef-b699-482d-95ce-e991c872d599.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### El Palmar National Park Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. [](https://expedia.com/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction) ![Parroquia Nuestra Señora de Itati](https://images.trvl-media.com/place/553248621532463967/dcc3f703-5a3b-46d8-99a7-83b2e87b8ea0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Basilica Nuestra Senora De Itati Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. [](https://expedia.com/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Vacation-Attraction) ![Punta San Sebastian, Corrientes, Costanera Corrientes](https://images.trvl-media.com/place/553248621532463961/5eccf4f4-bdb0-4368-8beb-0fffd1c8eab0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Costanera de Corrientes 4/5(2 reviews) Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area. [](https://expedia.com/Costanera-De-Corrientes-Corrientes.d553248621532463961.Vacation-Attraction) ![San José Palace](https://images.trvl-media.com/place/553248635974793605/0fefc8ed-f808-424a-94c4-7db511b97bd3.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San José Palace You can spend an afternoon exploring the galleries in San José Palace in Caseros. [](https://expedia.com/San-Jose-Palace-Caseros.d553248635974793605.Vacation-Attraction) #### Termas de Federacion Bring your family to Termas de Federacion and have a fun-filled day at this amusement park in Federacion. Stroll along the beaches or discover the area's waterfalls. [](https://expedia.com/Termas-De-Federacion-Federacion.d553248621532463682.Vacation-Attraction) #### Termas De Colón Enjoy an outing to Termas De Colón during your stay in Colon. Discover the area's theater scene and spas. [](https://expedia.com/Termas-De-Colon-Colon.d553248635939591385.Vacation-Attraction) ## Cities near Mesopotamia ![A view of the Costanera (Park by the Uruguay river) in Paso de los Libres, Argentina - the Brazilian city of Uruguaiana is seen in the background](https://images.trvl-media.com/place/397/6e7a89b1-35ec-4907-be62-f8aa32e06629.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Paso de los Libres ![Carpincho](https://images.trvl-media.com/place/892/473e6065-5cc5-43d8-8bed-7d5ace2c2904.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Concordia ![Rock formation "El Arco" at Lake Posadas, Argentina](https://images.trvl-media.com/place/2887/d836a022-182c-4be3-ade6-4b3bb9158f9d.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Posadas ![Adobe](https://images.trvl-media.com/place/3026/594454f8-3526-4642-9a20-13c59381f9fd.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Rosario - Cities near Mesopotamia - Places of interest [Paso de los Libres](https://expedia.com/Paso-De-Los-Libres.dx397)[Concordia](https://expedia.com/Concordia.dx892)[Paysandu](https://expedia.com/Paysandu.dx2758)[Posadas](https://expedia.com/Posadas.dx2887)[Rosario](https://expedia.com/Rosario.dx3026)[Santa Fe](https://expedia.com/Santa-Fe.dx3131)[Uruguaiana](https://expedia.com/Uruguaiana.dx3648)[Bella Vista](https://expedia.com/Bella-Vista.dx178069)[Parana](https://expedia.com/Parana.dx500197)[Carmelo](https://expedia.com/Carmelo.dx602813)[Campana](https://expedia.com/Campana.dx6034204)[Esquina](https://expedia.com/Esquina.dx6049079)[Ituzaingo](https://expedia.com/Ituzaingo.dx6049974)[Paso de la Patria](https://expedia.com/Paso-De-La-Patria.dx6050259)[Empedrado](https://expedia.com/Empedrado.dx6050260)[San Pedro](https://expedia.com/San-Pedro.dx6054166)[Corrientes](https://expedia.com/Corrientes.dx6054203)[Fray Bentos](https://expedia.com/Fray-Bentos.dx6085046)[Ramallo](https://expedia.com/Ramallo.dx6123950)[San Nicolas de los Arroyos](https://expedia.com/San-Nicolas-De-Los-Arroyos.dx6126774)[Federacion](https://expedia.com/Federacion.dx6141108)[Colon](https://expedia.com/Colon.dx6144191)[Cayasta](https://expedia.com/Cayasta.dx6146247)[Gualeguaychú](https://expedia.com/Gualeguaychu.dx6201387)[San Salvador](https://expedia.com/San-Salvador.dx6201389) - [Termas de Federacion ](https://expedia.com/Termas-De-Federacion-Federacion.d553248621532463682.Vacation-Attraction) - [El Palmar National Park ](https://expedia.com/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction) - [Basilica Nuestra Senora De Itati ](https://expedia.com/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Vacation-Attraction) - [Termas Concepcion Entrerios ](https://expedia.com/Termas-Concepcion-Entrerios-Concepcion-del-Uruguay.d553248621532463656.Vacation-Attraction) - [Costanera de Corrientes ](https://expedia.com/Costanera-De-Corrientes-Corrientes.d553248621532463961.Vacation-Attraction) - [Portal Carambola ](https://expedia.com/Portal-Carambola-Concepcion.d553248635998020259.Vacation-Attraction) - [Termas Del Ayui ](https://expedia.com/Termas-Del-Ayui-Concordia.d553248621532463677.Vacation-Attraction) - [Concordia Speedway ](https://expedia.com/Concordia-Speedway-Concordia.d6266695.Vacation-Attraction) - [Isla Cambacua Beach ](https://expedia.com/Isla-Cambacua-Beach-Concepcion-del-Uruguay.d553248635974793609.Vacation-Attraction) - [Termas de Chajarí ](https://expedia.com/Termas-De-Chajari-Chajari.d553248621532463686.Vacation-Attraction) - [San José Palace ](https://expedia.com/San-Jose-Palace-Caseros.d553248635974793605.Vacation-Attraction) - [Lago de Salto Grande ](https://expedia.com/Lago-De-Salto-Grande-South-America.d553248621532463678.Vacation-Attraction) - [Corsódromo ](https://expedia.com/Corsodromo-Gualeguaychu.d553248621532374259.Vacation-Attraction) - [3 de Feberero Municipal Theater ](https://expedia.com/3-De-Feberero-Municipal-Theater-Parana.d553248621562511935.Vacation-Attraction) - [Victoria Beach ](https://expedia.com/Victoria-Beach-Victoria.d6250473.Vacation-Attraction) - [Termas de Guaychu ](https://expedia.com/Termas-De-Guaychu-Entre-Rios-Province.d553248621532463653.Vacation-Attraction) - [Bodega Vulliez Sermet ](https://expedia.com/Bodega-Vulliez-Sermet-Colon.d553248621532463666.Vacation-Attraction) - [Velissa Spa Termal ](https://expedia.com/Velissa-Spa-Termal-Villa-Elisa.d553248621532463662.Vacation-Attraction) - [Church of St. Justo and Pastor ](https://expedia.com/Church-Of-St-Justo-And-Pastor-Colon.d6319241.Vacation-Attraction) - [Castillo San Carlos ](https://expedia.com/Castillo-San-Carlos-Concordia.d553248621532374268.Vacation-Attraction) - [Physical Education Center No 3 ](https://expedia.com/Physical-Education-Center-No-3-Concepcion-del-Uruguay.d820428155927654400.Vacation-Attraction) - [Col. C. Pelegrini Square ](https://expedia.com/Col-C-Pelegrini-Square-Colonia-Carlos-Pellegrini.d553248621564732249.Vacation-Attraction) - [Sala Evocativa de la Ribera ](https://expedia.com/Sala-Evocativa-De-La-Ribera-Concepcion-del-Uruguay.d553248621532463658.Vacation-Attraction) - [Concordia Golf Course ](https://expedia.com/Concordia-Golf-Course-Concordia.d6266691.Vacation-Attraction) - [Santa Rita de Casia Church ](https://expedia.com/Santa-Rita-De-Casia-Church-Esquina.d6279375.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app