Title: Santee Vacation Packages 2026 from $487 | Expedia.com [Santee Travel Guide](https://expedia.com/Santee.dx9953)[Hotels in Santee](https://expedia.com/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.com/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.com/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Car Rentals in Santee](https://expedia.com/Car-Rentals-In-Santee.d9953.Car-Rental-Guide) ![](https://images.trvl-media.com/place/9953/712fb946-715a-4a74-8bf7-2c2bbd891023.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Santee Vacations from $487 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Your Santee Vacation Enjoy unforgettable adventures when you book a vacation package to Santee. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this lively city. If your trip to Santee includes some sightseeing, don't miss famous attractions like [Santee State Park](https://www.expedia.com/Santee-State-Park-Santee.d6140632.Vacation-Attraction), [Santee Cooper Country Club](https://www.expedia.com/Santee-Cooper-Country-Club-Santee.d553248621532654899.Vacation-Attraction) and [Santee Outlets](https://www.expedia.com/Santee-Outlets-Santee.d6140634.Vacation-Attraction). Stop daydreaming and start traveling. Browse the many options on Expedia today and put your Santee vacation plans into action! ## The Latest Santee vacation packages Price found within the past 48 hours. Click for updated prices. ![Residence Inn by Marriott Columbia Northeast/Fort Jackson Area](https://images.trvl-media.com/lodging/2000000/1240000/1236800/1236733/c3cdc4d8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Residence Inn by Marriott Columbia Northeast/Fort Jackson Area $487 per person May 22 - May 27 found 1 day ago Roundtrip flight included New York (NYC) to Columbia (CAE) 9/10 Wonderful! (781 reviews) Good stay. Hotel starting to show its age. Reviewed on Jan 20, 2026 ![Courtyard by Marriott Columbia Downtown at USC](https://images.trvl-media.com/lodging/1000000/10000/2300/2289/w3996h2667x0y0-8dd1e3e0_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Courtyard by Marriott Columbia Downtown at USC Downtown Columbia $1,359 per person May 6 - May 10 found 22 hours ago Roundtrip non-stop flight included Boston (BOS) to Columbia (CAE) 8.8/10 Excellent! (1,002 reviews) Comfortable bed and pillow, a must for me! Clean room and great staff! Reviewed on Feb 16, 2026 ![Hampton Inn Columbia-Downtown Historic District](https://images.trvl-media.com/lodging/1000000/580000/570500/570428/e608f24b_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hampton Inn Columbia-Downtown Historic District Downtown Columbia $1,708 per person May 6 - May 10 found 22 hours ago Roundtrip non-stop flight included Boston (BOS) to Columbia (CAE) 8.8/10 Excellent! (1,002 reviews) Front desk was excellent! Reviewed on Feb 28, 2026 ![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](https://images.trvl-media.com/lodging/1000000/690000/688700/688607/805d082b_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG $866 per person May 6 - May 10 found 22 hours ago Roundtrip non-stop flight included Boston (BOS) to Columbia (CAE) 8.8/10 Excellent! (1,003 reviews) The room and the staff were great Reviewed on Feb 23, 2026 ![Sleep Inn Columbia](https://images.trvl-media.com/lodging/1000000/130000/127000/126908/de238acf_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Sleep Inn Columbia Seven Oaks $696 per person May 6 - May 10 found 22 hours ago Roundtrip non-stop flight included Boston (BOS) to Columbia (CAE) 8.2/10 Very Good! (1,005 reviews) Room was clean bedding was really nice. Reviewed on Feb 28, 2026 Don't see what you're looking for? See all available trips from Columbus to Santee [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-01/2026-04-08/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=CAE&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_9953) ### Discover the most popular places to visit in Santee #### Santee State Park You can take time to visit Santee State Park during your travels to Santee. While you're here, you can savor the top-notch restaurants. [](https://expedia.com/Santee-State-Park-Santee.d6140632.Vacation-Attraction) #### Santee Cooper Country Club Enjoy a round of golf in Santee at Santee Cooper Country Club. While you're here, you can savor the top-notch restaurants. [](https://expedia.com/Santee-Cooper-Country-Club-Santee.d553248621532654899.Vacation-Attraction) #### Santee National Golf Club Enjoy a round of golf in Santee at Santee National Golf Club. While you're here, you can savor the top-notch restaurants. [](https://expedia.com/Santee-National-Golf-Club-Santee.d553248621532654897.Vacation-Attraction) ## Santee Hotel Deals ![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Tru By Hilton Santee 263 Britain St. and 273 Britain St. Santee SC Fully refundableReserve now, pay when you stay $112 nightly $124 total Mar 9 - Mar 10 Total with taxes and fees 9.2/10 Wonderful! (740 reviews) Clean room; great breakfast Reviewed on Feb 27, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F9%2F2026&endDate=3%2F10%2F2026&selected=92600969&PinnedHotelID=92600969&HadPinnedHotel=true®ionId=9953) ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Baymont by Wyndham Santee 249 Britain Street Santee SC Fully refundableReserve now, pay when you stay $80 nightly $89 total Mar 2 - Mar 3 Total with taxes and fees 8/10 Very Good! (1,429 reviews) Excellent. Reviewed on Mar 1, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F2%2F2026&endDate=3%2F3%2F2026&selected=15379&PinnedHotelID=15379&HadPinnedHotel=true®ionId=9953) ![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Fairfield Inn & Suites by Marriott Santee 9074 Old Number Six Hwy Santee SC $125 nightly $139 total Mar 22 - Mar 23 Total with taxes and fees 9.8/10 Exceptional! (1,006 reviews) Clean comfortable stay. Breakfast was a nice plus. Reviewed on Feb 28, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F22%2F2026&endDate=3%2F23%2F2026&selected=26116&PinnedHotelID=26116&HadPinnedHotel=true®ionId=9953) [See all 306 properties in Santee](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F2%2F2026&endDate=3%2F3%2F2026®ionId=9953) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Santee Vacation Packages ## Santee Essential Information | Language | English | | --------------- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | U.S dollars | | Population | 940 | | Max Temp Winter | 55ºF | | Max Temp Summer | 90ºF | | Top Sights | [Santee State Park](https://www.expedia.com/Santee-State-Park-Santee.d6140632.Vacation-Attraction), [Santee Cooper Country Club](https://www.expedia.com/Santee-Cooper-Country-Club-Santee.d553248621532654899.Vacation-Attraction) and [Santee National Golf Club](https://www.expedia.com/Santee-National-Golf-Club-Santee.d553248621532654897.Vacation-Attraction) | ## More vacations 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![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations 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