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Our top choices for Southeast Missouri vacation homes
In-law Suite
In-law SuiteLeadwood
9.8 out of 10, Exceptional, (14)
"Well taken care of, nice amenities, comfortable."
Daniel K.
$195 nightly
The price is $195
Dec 19 - Dec 20
Total with taxes and fees
10.0 out of 10, Exceptional, (3)
"Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again."
Norma
$304 nightly
The price is $323
Dec 17 - Dec 18
Total with taxes and fees
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar BluffPoplar Bluff
8.8 out of 10, Excellent, (9)
"The house was very clean and nicely decorated. The huge TV in the living room was a plus and the mattress was very comfortable. We would stay again!"
Brian
$254 nightly
The price is $254
Dec 27 - Dec 28
Total with taxes and fees
Goforth into Nature, a charming 1-bdrm home in the quiet Bloomsdale countryside.
Goforth into Nature, a charming 1-bdrm home in the quiet Bloomsdale countryside.Bloomsdale
10.0 out of 10, Exceptional, (6)
"What a beautiful fun stay that was a nice quick getaway for us! Everything was perfect from booking, to arrival, to overall stay, we had the best time! "
Blake H.
$245 nightly
The price is $261
Dec 17 - Dec 18
Total with taxes and fees
Cozy 1-bedroom house with AC and WiFi in charming Farmington
Cozy 1-bedroom house with AC and WiFi in charming FarmingtonFarmington
10.0 out of 10, Exceptional, (6)
"Absolutely LOVED it here! Hope to return in 2026. Karli made my first Vrbo experience just plain splendid!"
Tru L.
$179 nightly
The price is $185
Dec 17 - Dec 18
Total with taxes and fees
Charming 2-bedroom house with AC, WiFi in serene Van Buren
Charming 2-bedroom house with AC, WiFi in serene Van BurenVan Buren
9.0 out of 10, Wonderful, (15)
"It was beautiful and homey. We really enjoyed our stay. "
Jessica
$160 nightly
The price is $168
Dec 17 - Dec 18
Total with taxes and fees
Get Away Acres 1/2 mile off highway 60 extra sanitized
Get Away Acres 1/2 mile off highway 60 extra sanitizedEllsinore
10.0 out of 10, Exceptional, (95)
"We really enjoyed our stay! Host was very friendly and quick to respond to questions! We will definitely stay again!!"
Anonymous traveler
$125 nightly
The price is $131
Jan 1 - Jan 2, 2026
Total with taxes and fees
The Morning Glory - Country Cottage
The Morning Glory - Country CottagePiggott
10.0 out of 10, Exceptional, (2)
"Great stay. Home was just as advertised. Great communication with owner. Will visit again. "
Scott C.
$218 nightly
The price is $240
Dec 30 - Dec 31
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews
Holiday Inn Poplar Bluff by IHG
10/10 Excellent
Find out more about Southeast Missouri
Southeast Missouri Vacation Homes information
Number of reviews | 420 |
|---|---|
Accommodation | 190 Vacation Homes |
Lowest Price | $131 |
Highest Price | $323 |
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