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Find Winery Hotels in Southeast Missouri, MO

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Check availability on Southeast Missouri Winery Hotels

Tonight
Dec 8 - Dec 9
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Dec 9 - Dec 10
This weekend
Dec 12 - Dec 14
Next weekend
Dec 19 - Dec 21

Top Southeast Missouri Winery Hotels

Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (661)
"Great place "
United States
GUY
$78 nightly
The price is $85
Jan 4 - Jan 5, 2026
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Meeting facility
Baymont by Wyndham Festus

Baymont by Wyndham Festus

3.0 star property
Festus
6.8 out of 10, (918)
"Room was clean and comfortable for an overnight stay"
United States
Jack
$81 nightly
The price is $93
Dec 11 - Dec 12
Total with taxes and fees
Baymont by Wyndham Festus
Fridge, microwave, oven, stovetop
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

2.0 star property
Ste. Genevieve
10.0 out of 10, Exceptional, (18)
"Great historic property!"
United States
Rhonda R.
$231 nightly
The price is $231
Dec 12 - Dec 13
Total with taxes and fees
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
Outdoor dining
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

2.0 star property
Farmington
10.0 out of 10, Exceptional, (11)
"Great place and very comfortable! Hosts were super attentive when our door code didn’t work and got us sorted out right away. "
United States
Kyser B.
$219 nightly
The price is $230
Dec 10 - Dec 11
Total with taxes and fees
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
1 bedroom, iron/ironing board, bed sheets
Beautiful Modern Loft In Wine Country!

Beautiful Modern Loft In Wine Country!

Ste. Genevieve
10.0 out of 10, Exceptional, (271)
"Loved our stay here! Thoughtful amenities on a beautiful property. Great communication with host. "
United States
Elsie H.
$168 nightly
The price is $179
Dec 11 - Dec 12
Total with taxes and fees
Beautiful Modern Loft In Wine Country!
Dining
Goforth into Nature, a charming 1-bdrm home in the quiet Bloomsdale countryside.

Goforth into Nature, a charming 1-bdrm home in the quiet Bloomsdale countryside.

Bloomsdale
10.0 out of 10, Exceptional, (6)
"What a beautiful fun stay that was a nice quick getaway for us! Everything was perfect from booking, to arrival, to overall stay, we had the best time! "
United States
Blake H.
$245 nightly
The price is $261
Dec 16 - Dec 17
Total with taxes and fees
Goforth into Nature, a charming 1-bdrm home in the quiet Bloomsdale countryside.
Property grounds
The Weber Farm - Enjoy a beautiful 100 acre farm!

The Weber Farm - Enjoy a beautiful 100 acre farm!

Frohna
10.0 out of 10, Exceptional, (32)
"Hosts were great. I just wish they had a second bath or atleast a larger bathroom. "
United States
Dennis H.
$178 nightly
The price is $184
Dec 9 - Dec 10
Total with taxes and fees
The Weber Farm - Enjoy a beautiful 100 acre farm!
Exterior detail
"Little Brick House on Main (1865)”

"Little Brick House on Main (1865)”

Ste. Genevieve
10.0 out of 10, Exceptional, (63)
"Great place to stay!"
United States
Lettitia B.
$159 nightly
The price is $159
Dec 9 - Dec 10
Total with taxes and fees
"Little Brick House on Main (1865)”
Fridge, microwave, oven, stovetop
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
$229 nightly
The price is $245
Dec 9 - Dec 10
Total with taxes and fees
Serenity South -- Gardens, River-Views, and Refreshing Space
Fridge, microwave, oven, stovetop
Newly renovated early 1900’s farmhouse

Newly renovated early 1900’s farmhouse

Birch Tree
10.0 out of 10, Exceptional, (21)
"Place was perfect for our stay. Beautiful property. "
United States
Drew W.
$244 nightly
The price is $255
Jan 4 - Jan 5, 2026
Total with taxes and fees
Newly renovated early 1900’s farmhouse
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"Very good hotel for the price."
Gareth 1-night trip
Posted 3 days ago
Drury Inn & Suites Jackson MO
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent
"Was very good stay"
A 2-night trip
Posted 6 days ago
Baymont Inn and Suites by Wyndham Farmington, MO

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