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Find pet-friendly hotels in Southeast Missouri, MO from $60

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Top Southeast Missouri Pet-friendly Hotels

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (437)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
$95 nightly
The price is $108
Dec 14 - Dec 15
Total with taxes and fees
Hampton Inn Sikeston

Pear Tree Inn Sikeston

2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
"Everything was clean, staff was friendly "
United States
Matthew
$77 nightly
The price is $89
Dec 8 - Dec 9
Total with taxes and fees
Pear Tree Inn Sikeston

EC Reed's Mercantile and Hotel

3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (83)
"Cute room, great food, fun soda fountain and friendly owners! Will return! "
United States
Leslie
$117 nightly
The price is $127
Dec 4 - Dec 5
Total with taxes and fees
EC Reed's Mercantile and Hotel

Drury Inn & Suites Jackson MO

3.0 star property
Jackson
9.6 out of 10, Exceptional, (1013)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
$83 nightly
The price is $88
Dec 4 - Dec 5
Total with taxes and fees
Drury Inn & Suites Jackson MO

Super 8 by Wyndham Union

2.0 star property
Union
8.2 out of 10, Very Good, (631)
"Everything about our room and stay were perfect."
United States
Neila
$75 nightly
The price is $83
Jan 3 - Jan 4, 2026
Total with taxes and fees
Super 8 by Wyndham Union

Super 8 by Wyndham Potosi

2.0 star property
Potosi
7.0 out of 10, Good, (378)
"The room was very good for the price."
United States
Benjamin
$55 nightly
The price is $60
Dec 4 - Dec 5
Total with taxes and fees
Super 8 by Wyndham Potosi

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"Clean room, great location and friendly staff"
United States
Mark
$90 nightly
The price is $103
Dec 8 - Dec 9
Total with taxes and fees
Drury Inn & Suites Sikeston, MO

Comfort Inn Sullivan

2.5 star property
Sullivan
8.6 out of 10, Excellent, (802)
"Room was nice. Hotel is renovating at the moment. Beds were a little high. "
United States
Janet
$120 nightly
The price is $130
Jan 1 - Jan 2, 2026
Total with taxes and fees
Comfort Inn Sullivan

Super 8 by Wyndham Cuba

2.0 star property
Cuba
8.8 out of 10, Excellent, (984)
"Great place to stay if floating river."
United States
Denise
$83 nightly
The price is $95
Dec 7 - Dec 8
Total with taxes and fees
Super 8 by Wyndham Cuba
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Southeast Missouri

Discover top Southeast Missouri attractions with your pet

Southeast Missouri is a hidden gem for travelers with pets seeking both adventure and comfort. Begin your journey at the stunning Ozark National Scenic Riverways, where you can paddle down the Current or Jacks Fork Rivers with your furry friend by your side, enjoying the breathtaking scenery and wildlife. Next, explore the charming town of Cape Girardeau, where you can stroll along the riverfront and visit the Cape River Heritage Museum, all while your pet enjoys the sights and smells of this vibrant area. For those who love hiking, the Mark Twain National Forest offers numerous trails where pets are welcome, allowing you and your four-legged companion to explore the diverse flora and fauna together. Don't miss the opportunity to visit the picturesque Trail of Tears State Park, which features beautiful vistas and walking trails that are pet-friendly. Finally, you can unwind at one of the many pet-friendly hotels in the region, like the Quality Inn in Cape Girardeau, which offers comfortable accommodations and easy access to local attractions. Here, you can relax knowing your pet is with you, while you enjoy a quality stay with attentive service that caters to your every need. This blend of outdoor activities and welcoming hospitality makes Southeast Missouri a perfect choice for a memorable getaway with your pet.

Top Southeast Missouri Hotel Reviews

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