$356 Cheap Flights from St. John's (ANU) to Knoxville (TYS)

View $356 flight on Thu, Mar 19, 2026Opens in a new window

Popular airlines from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS)

Cheap Flights from St. John's to Knoxville (ANU-TYS)

Prices were available within the past 7 days and start at $356 for one-way flights and $626 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, May 23 - Sat, May 30
ANU
Antigua
TYS
Knoxville
$626 Roundtrip, found 3 days ago
$626
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, May 23 from Antigua to Knoxville, returning Sat, May 30, priced at $626 found 3 days ago
American Airlines
Sat, May 23 - Sat, May 30
ANU
Antigua
TYS
Knoxville
$634 Roundtrip, found 3 days ago
$634
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, May 23 from Antigua to Knoxville, returning Sat, May 30, priced at $634 found 3 days ago
American Airlines
Sat, May 23 - Sat, May 30
ANU
Antigua
TYS
Knoxville
$703 Roundtrip, found 3 days ago
$703
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, May 23 from Antigua to Knoxville, returning Sat, May 30, priced at $703 found 3 days ago
American Airlines
Sat, May 23 - Sat, May 30
ANU
Antigua
TYS
Knoxville
$724 Roundtrip, found 3 days ago
$724
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, May 23 from Antigua to Knoxville, returning Sat, May 30, priced at $724 found 3 days ago
American Airlines
Sat, May 23 - Sat, May 30
ANU
Antigua
TYS
Knoxville
$730 Roundtrip, found 3 days ago
$730
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, May 23 from Antigua to Knoxville, returning Sat, May 30, priced at $730 found 3 days ago
American Airlines
Sat, May 23 - Sat, May 30
ANU
Antigua
TYS
Knoxville
$739 Roundtrip, found 3 days ago
$739
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, May 23 from Antigua to Knoxville, returning Sat, May 30, priced at $739 found 3 days ago
American Airlines
Sat, May 23 - Sat, May 30
ANU
Antigua
TYS
Knoxville
$746 Roundtrip, found 3 days ago
$746
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, May 23 from Antigua to Knoxville, returning Sat, May 30, priced at $746 found 3 days ago
American Airlines
Sat, May 23 - Sat, May 30
ANU
Antigua
TYS
Knoxville
$747 Roundtrip, found 3 days ago
$747
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, May 23 from Antigua to Knoxville, returning Sat, May 30, priced at $747 found 3 days ago
American Airlines
Sat, May 23 - Sat, May 30
ANU
Antigua
TYS
Knoxville
$753 Roundtrip, found 3 days ago
$753
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, May 23 from Antigua to Knoxville, returning Sat, May 30, priced at $753 found 3 days ago
Delta
Sat, May 23 - Sat, May 30
ANU
Antigua
TYS
Knoxville
$1,018 Roundtrip, found 3 days ago
$1,018
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, May 23 from Antigua to Knoxville, returning Sat, May 30, priced at $1,018 found 3 days ago

Frequently asked questions

How much does a flight from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS) cost?
Secure a cheap one-way flight from $356 or cheap return flight from $626 from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS)?
The cheapest month to fly from ANU to TYS is May, when demand is low. Off-peak season is often when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS)?
To find the cheapest airline that'll fly you from ANU to TYS, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS)?
There aren't any daily direct flights departing from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be on your way before you know it.
What day of the week has the most flights from ANU to TYS?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* But this can vary based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS)?
Book a flight from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS) last-minute?
Waiting until just before your departure to book a flight from ANU to TYS generally means paying more. While you may find some last-minute discounts, they aren't always guaranteed. Be flexible with your travel plans to boost your chances of landing a bargain.
Is it cheaper to book an ANU to TYS flight and hotel package?
Securing an ANU to TYS flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Pick from our extensive range of accommodations and then add flights, car rentals and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from V.C. Bird Intl. Airport (ANU) to McGhee Tyson Airport (TYS)?
If you booked your ANU to TYS flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
V.C. Bird Intl.
Destination airport
McGhee Tyson
Roundtrip price
$625
Distance
1874 mi

Book with confidence

St. John's to Knoxville Flights

The cheapest times to fly from St. John's to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. John's to Knoxville are during the month of May. You can find some of the cheapest flights from St. John's to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. John's to Knoxville

Sunday is one of the best days to book for cheap flights from St. John's to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. John's to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. John's to Knoxville in 2026. You can also book with separate airlines for your outbound and return journeys, from $356 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. John's to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. John's to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. John's to Knoxville Flights

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*Available to One Key members.