$231 Cheap Flights from Key West (EYW) to Knoxville (TYS)

View $231 flight on Wed, Jan 7, 2026Opens in a new window

Popular airlines from Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS)

Cheap Flights from Key West to Knoxville (EYW-TYS)

Prices were available within the past 7 days and start at $231 for one-way flights and $231 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Jan 22 - Sun, Jan 25
EYW
Key West
TYS
Knoxville
$231 Roundtrip, found 5 days ago
$231
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Jan 22 from Key West to Knoxville, returning Sun, Jan 25, priced at $231 found 5 days ago
Delta
Tue, Feb 24 - Tue, Mar 10
EYW
Key West
TYS
Knoxville
$240 Roundtrip, found 6 days ago
$240
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Feb 24 from Key West to Knoxville, returning Tue, Mar 10, priced at $240 found 6 days ago
Delta
Wed, Feb 11 - Mon, Feb 23
EYW
Key West
TYS
Knoxville
$241 Roundtrip, found 6 days ago
$241
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Feb 11 from Key West to Knoxville, returning Mon, Feb 23, priced at $241 found 6 days ago
Delta
Fri, Dec 5 - Fri, Dec 12
EYW
Key West
TYS
Knoxville
$249 Roundtrip, found 1 day ago
$249
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Dec 5 from Key West to Knoxville, returning Fri, Dec 12, priced at $249 found 1 day ago
Delta
Sun, Feb 8 - Mon, Feb 23
EYW
Key West
TYS
Knoxville
$250 Roundtrip, found 6 days ago
$250
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Feb 8 from Key West to Knoxville, returning Mon, Feb 23, priced at $250 found 6 days ago
Delta
Wed, Dec 3 - Wed, Dec 10
EYW
Key West
TYS
Knoxville
$254 Roundtrip, found 5 days ago
$254
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Dec 3 from Key West to Knoxville, returning Wed, Dec 10, priced at $254 found 5 days ago
Delta
Thu, Dec 4 - Fri, Dec 12
EYW
Key West
TYS
Knoxville
$264 Roundtrip, found 1 day ago
$264
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Dec 4 from Key West to Knoxville, returning Fri, Dec 12, priced at $264 found 1 day ago
American Airlines
Wed, Dec 3 - Wed, Dec 10
EYW
Key West
TYS
Knoxville
$266 Roundtrip, found 5 days ago
$266
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Dec 3 from Key West to Knoxville, returning Wed, Dec 10, priced at $266 found 5 days ago
Delta
Tue, Feb 3 - Thu, Feb 19
EYW
Key West
TYS
Knoxville
$267 Roundtrip, found 6 days ago
$267
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Feb 3 from Key West to Knoxville, returning Thu, Feb 19, priced at $267 found 6 days ago
United
Fri, Nov 7 - Tue, Nov 11
EYW
Key West
TYS
Knoxville
$967 Roundtrip, found 1 hour ago
$967
Roundtrip
found 1 hour ago
Select United flight, departing Fri, Nov 7 from Key West to Knoxville, returning Tue, Nov 11, priced at $967 found 1 hour ago
Flights from Key West (EYW) to Knoxville (TYS)
Origin airport
Key West Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, United
Roundtrip price
$230
Distance
788 mi
Average flight time
2 hours 15 mins

Key West to Knoxville Flights

The cheapest times to fly from Key West to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Key West to Knoxville are during the month of January. You can find some of the cheapest flights from Key West to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Key West to Knoxville

Sunday is one of the best days to book for cheap flights from Key West to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Key West to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Key West to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $231 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Key West to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Key West to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS) cost?
Snag a cheap one-way flight from $231 or cheap return flight from $231 from Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS)?
January is the most affordable month to fly from EYW to TYS. Traveling outside of peak seasons is often the key to scoring lower fares.
What is the cheapest airline that flies from Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest EYW to TYS flight.
How many flights per day from Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS)?
You'll have to catch a flight with a layover when traveling from Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS). There are no daily direct flights on this route. However, just filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from EYW to TYS?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can change based on various factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS)?
To avoid possible delays on the Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS) route, aim to travel before 3 PM. Departures after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS) last-minute?
Last-minute bookings from EYW to TYS are usually more expensive. To secure the best rates, start looking for flights early. That being said, if you can play around with your travel dates, you may score a cheap fare right before you leave.
Is it cheaper to book an EYW to TYS flight and hotel package?
You'll typically save money by booking an EYW to TYS flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. After selecting your preferred flights and accommodations, you can add extras such as car rentals, tours and activities.
Can I cancel or change the date of my flight from Key West Intl. Airport (EYW) to McGhee Tyson Airport (TYS)?
Typically, you can cancel or modify your EYW to TYS flight. However, there may be additional fees, especially if your booking was made more than 24 hours ago. Check your itinerary for the airline's fees and guidelines on flight changes, or if you want further information, head to our Customer Service portal.

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*Available to One Key members.