$223 Cheap Flights from Lafayette (LAF) to Knoxville (TYS)

View $223 flight on Sun, Nov 16, 2025Opens in a new window

Popular airlines from Lafayette, IN (LAF-Purdue University) to McGhee Tyson Airport (TYS)

Cheap Flights from Lafayette to Knoxville (LAF-TYS)

Prices were available within the past 7 days and start at $223 for one-way flights and $263 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Mon, Jan 12 - Fri, Jan 23
LAF
Lafayette
TYS
Knoxville
$263 Roundtrip, found 3 days ago
$263
Roundtrip
found 3 days ago
Select United flight, departing Mon, Jan 12 from Lafayette to Knoxville, returning Fri, Jan 23, priced at $263 found 3 days ago
United
Wed, Nov 19 - Sat, Nov 22
LAF
Lafayette
TYS
Knoxville
$284 Roundtrip, found 17 hours ago
$284
Roundtrip
found 17 hours ago
Select United flight, departing Wed, Nov 19 from Lafayette to Knoxville, returning Sat, Nov 22, priced at $284 found 17 hours ago
United
Mon, Nov 10 - Sun, Nov 23
LAF
Lafayette
TYS
Knoxville
$289 Roundtrip, found 3 days ago
$289
Roundtrip
found 3 days ago
Select United flight, departing Mon, Nov 10 from Lafayette to Knoxville, returning Sun, Nov 23, priced at $289 found 3 days ago
United
Mon, Nov 10 - Sat, Nov 15
LAF
Lafayette
TYS
Knoxville
$294 Roundtrip, found 3 days ago
$294
Roundtrip
found 3 days ago
Select United flight, departing Mon, Nov 10 from Lafayette to Knoxville, returning Sat, Nov 15, priced at $294 found 3 days ago
United
Mon, Nov 17 - Sat, Nov 22
LAF
Lafayette
TYS
Knoxville
$299 Roundtrip, found 17 hours ago
$299
Roundtrip
found 17 hours ago
Select United flight, departing Mon, Nov 17 from Lafayette to Knoxville, returning Sat, Nov 22, priced at $299 found 17 hours ago
United
Mon, Nov 3 - Tue, Nov 18
LAF
Lafayette
TYS
Knoxville
$309 Roundtrip, found 3 days ago
$309
Roundtrip
found 3 days ago
Select United flight, departing Mon, Nov 3 from Lafayette to Knoxville, returning Tue, Nov 18, priced at $309 found 3 days ago
United
Tue, Nov 4 - Mon, Nov 10
LAF
Lafayette
TYS
Knoxville
$314 Roundtrip, found 3 days ago
$314
Roundtrip
found 3 days ago
Select United flight, departing Tue, Nov 4 from Lafayette to Knoxville, returning Mon, Nov 10, priced at $314 found 3 days ago
United
Mon, Jan 12 - Fri, Jan 23
LAF
Lafayette
TYS
Knoxville
$323 Roundtrip, found 3 days ago
$323
Roundtrip
found 3 days ago
Select United flight, departing Mon, Jan 12 from Lafayette to Knoxville, returning Fri, Jan 23, priced at $323 found 3 days ago
United
Fri, Jan 9 - Mon, Jan 26
LAF
Lafayette
TYS
Knoxville
$350 Roundtrip, found 2 days ago
$350
Roundtrip
found 2 days ago
Select United flight, departing Fri, Jan 9 from Lafayette to Knoxville, returning Mon, Jan 26, priced at $350 found 2 days ago
United
Wed, Nov 19 - Mon, Nov 24
LAF
Lafayette
TYS
Knoxville
$351 Roundtrip, found 17 hours ago
$351
Roundtrip
found 17 hours ago
Select United flight, departing Wed, Nov 19 from Lafayette to Knoxville, returning Mon, Nov 24, priced at $351 found 17 hours ago

Frequently asked questions

How much does a flight from Lafayette, IN (LAF-Purdue University) to McGhee Tyson Airport (TYS) cost?
Lock in a cheap one-way flight from $223 or cheap return flight from $263 from Lafayette, IN (LAF-Purdue University) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Lafayette, IN (LAF-Purdue University) to McGhee Tyson Airport (TYS)?
Planning your trip for January may help you find better deals, as it's the cheapest month for flights between LAF and TYS. You'll typically find the lowest fares during off-peak months.
What is the cheapest airline that flies from Lafayette, IN (LAF-Purdue University) to McGhee Tyson Airport (TYS)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest LAF to TYS flight.
How many flights per day from Lafayette, IN (LAF-Purdue University) to McGhee Tyson Airport (TYS)?
You'll have to take a flight with a layover when traveling from Lafayette, IN (LAF-Purdue University) to McGhee Tyson Airport (TYS). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from LAF to TYS?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* But this can change depending on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lafayette, IN (LAF-Purdue University) to McGhee Tyson Airport (TYS)?
To arrive at McGhee Tyson Airport (TYS) on schedule, opt for a flight that leaves Lafayette, IN (LAF-Purdue University) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lafayette, IN (LAF-Purdue University) to McGhee Tyson Airport (TYS) last-minute?
Booking your flight from LAF to TYS right before your trip is generally more expensive. However, if there's some wiggle room with your travel dates and times, you could land a cheap last-minute fare.
Is it cheaper to book a LAF to TYS flight and hotel package?
You can save money by booking a LAF to TYS flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. Once you've chosen your preferred accommodations and flights, consider adding extras like car rentals, activities and tours.
Can I cancel or change the date of my flight from Lafayette, IN (LAF-Purdue University) to McGhee Tyson Airport (TYS)?
Typically, it's possible to cancel or reschedule your LAF to TYS flight. However, for bookings made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Purdue University
Destination airport
McGhee Tyson
Airlines serving
United
Roundtrip price
$263
Distance
356 mi

Book with confidence

Lafayette to Knoxville Flights

The cheapest times to fly from Lafayette to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lafayette to Knoxville are during the month of January. You can find some of the cheapest flights from Lafayette to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lafayette to Knoxville

Sunday is one of the best days to book for cheap flights from Lafayette to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lafayette to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lafayette to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $223 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lafayette to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lafayette to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Lafayette to Knoxville Flights

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*Available to One Key members.