$523 Cheap Flights from Lyon (LYS) to Knoxville (TYS)

View $523 flight on Wed, Feb 25, 2026Opens in a new window

Popular airlines from Lyon to Knoxville, TN (TYS-McGhee Tyson)

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Cheap Flights from Lyon to Knoxville (LYS-TYS)

Prices were available within the past 7 days and start at $523 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from Saint-Exupery Airport (LYS) to McGhee Tyson Airport (TYS) cost?
Secure a cheap one-way flight from $523 or cheap return flight from Saint-Exupery Airport (LYS) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Saint-Exupery Airport (LYS) to McGhee Tyson Airport (TYS)?
The cheapest month to fly from LYS to TYS is , when demand is low. Off-peak months are usually when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Saint-Exupery Airport (LYS) to McGhee Tyson Airport (TYS)?
To find the cheapest airline flying from LYS to TYS, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Saint-Exupery Airport (LYS) to McGhee Tyson Airport (TYS)?
You'll need to hop on a flight with a layover when traveling from Saint-Exupery Airport (LYS) to McGhee Tyson Airport (TYS). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from LYS to TYS?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can change depending on a number of factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Saint-Exupery Airport (LYS) to McGhee Tyson Airport (TYS)?
To arrive at McGhee Tyson Airport (TYS) on schedule, select a flight that takes off from Saint-Exupery Airport (LYS) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Saint-Exupery Airport (LYS) to McGhee Tyson Airport (TYS) last-minute?
Booking your plane ticket from LYS to TYS shortly before your journey is usually more expensive. However, if there's some wiggle room with your travel times and dates, you could score a cheap last-minute fare.
Is it cheaper to book a LYS to TYS flight and hotel package?
Securing a LYS to TYS flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Pick from our extensive range of accommodations and then add flights, activities and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Saint-Exupery Airport (LYS) to McGhee Tyson Airport (TYS)?
In most cases, you can cancel or reschedule your LYS to TYS flight. However, there may be additional fees, especially if you made your booking more than 24 hours ago. Double-check your itinerary for the airline's policies and fees on flight changes, or if you want further details, head to our Customer Service portal.

Travel information

Origin airport
Saint-Exupery
Destination airport
McGhee Tyson
Distance
4466 mi

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Lyon to Knoxville Flights

The cheapest times to fly from Lyon to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lyon to Knoxville are during the month of . You can find some of the cheapest flights from Lyon to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lyon to Knoxville

Sunday is one of the best days to book for cheap flights from Lyon to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lyon to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lyon to Knoxville in 2026. You can also book with separate airlines for your outbound and return journeys, from $523 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lyon to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lyon to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Lyon to Knoxville Flights

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*Available to One Key members.