$148 Cheap Flights from Medford (MFR) to St. Louis (STL)

View $148 flight on Wed, Mar 11, 2026Opens in a new window

Popular airlines from Rogue Valley Intl. Airport (MFR) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Medford to St. Louis (MFR-STL)

Prices were available within the past 7 days and start at $148 for one-way flights and $256 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Dec 25 - Tue, Jan 6
MFR
Medford
STL
St. Louis
$256 Roundtrip, found 2 days ago
$256
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Dec 25 from Medford to St. Louis, returning Tue, Jan 6, priced at $256 found 2 days ago
Delta
Mon, Dec 15 - Wed, Dec 31
MFR
Medford
STL
St. Louis
$272 Roundtrip, found 3 days ago
$272
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Dec 15 from Medford to St. Louis, returning Wed, Dec 31, priced at $272 found 3 days ago
Delta
Tue, Feb 10 - Tue, Feb 17
MFR
Medford
STL
St. Louis
$288 Roundtrip, found 2 days ago
$288
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Feb 10 from Medford to St. Louis, returning Tue, Feb 17, priced at $288 found 2 days ago
Delta
Sat, Jan 17 - Tue, Jan 20
MFR
Medford
STL
St. Louis
$315 Roundtrip, found 5 days ago
$315
Roundtrip
found 5 days ago
Select Delta flight, departing Sat, Jan 17 from Medford to St. Louis, returning Tue, Jan 20, priced at $315 found 5 days ago
Delta
Tue, Feb 10 - Tue, Feb 17
MFR
Medford
STL
St. Louis
$322 Roundtrip, found 2 days ago
$322
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Feb 10 from Medford to St. Louis, returning Tue, Feb 17, priced at $322 found 2 days ago
Hawaiian Airlines
Thu, Dec 25 - Mon, Jan 5
MFR
Medford
STL
St. Louis
$324 Roundtrip, found 2 days ago
$324
Roundtrip
found 2 days ago
Select Hawaiian Airlines flight, departing Thu, Dec 25 from Medford to St. Louis, returning Mon, Jan 5, priced at $324 found 2 days ago
Hawaiian Airlines
Wed, Dec 24 - Wed, Jan 7
MFR
Medford
STL
St. Louis
$331 Roundtrip, found 2 days ago
$331
Roundtrip
found 2 days ago
Select Hawaiian Airlines flight, departing Wed, Dec 24 from Medford to St. Louis, returning Wed, Jan 7, priced at $331 found 2 days ago
Alaska Airlines
Tue, Feb 10 - Tue, Feb 17
MFR
Medford
STL
St. Louis
$335 Roundtrip, found 2 days ago
$335
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Tue, Feb 10 from Medford to St. Louis, returning Tue, Feb 17, priced at $335 found 2 days ago
United
Sat, Jan 17 - Tue, Jan 20
MFR
Medford
STL
St. Louis
$348 Roundtrip, found 5 days ago
$348
Roundtrip
found 5 days ago
Select United flight, departing Sat, Jan 17 from Medford to St. Louis, returning Tue, Jan 20, priced at $348 found 5 days ago
American Airlines
Wed, Dec 3 - Sun, Dec 7
MFR
Medford
STL
St. Louis
$541 Roundtrip, found 8 hours ago
$541
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Dec 3 from Medford to St. Louis, returning Sun, Dec 7, priced at $541 found 8 hours ago

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Find the cheapest month to fly from Medford (MFR) to St. Louis (STL)

January is typically the cheapest month to fly

From $291 - $741 per traveler.

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $396
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $396
Flights from Medford (MFR) to St. Louis (STL)
Origin airport
Rogue Valley Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
Alaska Airlines, American Airlines, Delta, Hawaiian Airlines, United
Roundtrip price
$255
Distance
1714 mi

Medford to St. Louis Flights

The cheapest times to fly from Medford to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medford to St. Louis are during the month of December. You can find some of the cheapest flights from Medford to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medford to St. Louis

Sunday is one of the best days to book for cheap flights from Medford to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medford to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medford to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $148 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medford to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medford to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Rogue Valley Intl. Airport (MFR) to Lambert-St. Louis Intl. Airport (STL) cost?
Lock in a cheap one-way flight from $148 or cheap return flight from $256 from Rogue Valley Intl. Airport (MFR) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Rogue Valley Intl. Airport (MFR) to Lambert-St. Louis Intl. Airport (STL)?
Planning your getaway for December may help you find better deals, as it's the cheapest month for flights between MFR and STL. You'll usually find the lowest fares during the off-season.
What is the cheapest airline that flies from Rogue Valley Intl. Airport (MFR) to Lambert-St. Louis Intl. Airport (STL)?
Use the filters on Expedia to compare different airlines and find the most affordable carrier that'll take you from MFR to STL. Then, sort your results by "Price (lowest to highest)" to snap up the best deal available.
How many flights per day from Rogue Valley Intl. Airport (MFR) to Lambert-St. Louis Intl. Airport (STL)?
There are no daily direct flights from Rogue Valley Intl. Airport (MFR) to Lambert-St. Louis Intl. Airport (STL). But you can choose flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be on your way in no time.
What day of the week has the most flights from MFR to STL?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary depending on various factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Rogue Valley Intl. Airport (MFR) to Lambert-St. Louis Intl. Airport (STL)?
Opt for a flight from Rogue Valley Intl. Airport (MFR) to Lambert-St. Louis Intl. Airport (STL) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Rogue Valley Intl. Airport (MFR) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Booking your ticket from MFR to STL just before your trip is usually more expensive. However, if you're flexible with your itinerary, you could snag a cheap last-minute fare.
Is it cheaper to book a MFR to STL flight and hotel package?
You'll typically save money by booking a MFR to STL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. After choosing your preferred accommodations and flights, you can add extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Rogue Valley Intl. Airport (MFR) to Lambert-St. Louis Intl. Airport (STL)?
Usually, it's possible to reschedule or cancel your MFR to STL flight. However, for bookings made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.