USA, New York, Niagara Falls. American & Bridal Veil Falls crash over the rocks in thundering glory, Niagara Falls, New York.

$269 Cheap Flights from Moline (MLI) to Buffalo (BUF)

View $269 flight on Tue, Sep 8, 2026Opens in a new window

Popular airlines from Quad City Intl. Airport (MLI) to Buffalo Niagara Intl. Airport (BUF)

Cheap Flights from Moline to Buffalo (MLI-BUF)

Prices were available within the past 7 days and start at $269 for one-way flights and $309 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Jul 20 - Sat, Jul 25
MLI
Moline
BUF
Buffalo
$309 Roundtrip, found 10 hours ago
$309
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Mon, Jul 20 from Moline to Buffalo, returning Sat, Jul 25, priced at $309 found 10 hours ago
American Airlines
Thu, Jul 16 - Sun, Jul 19
MLI
Moline
BUF
Buffalo
$319 Roundtrip, found 5 days ago
$319
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Jul 16 from Moline to Buffalo, returning Sun, Jul 19, priced at $319 found 5 days ago
American Airlines
Thu, Jul 2 - Fri, Jul 3
MLI
Moline
BUF
Buffalo
$324 Roundtrip, found 1 day ago
$324
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jul 2 from Moline to Buffalo, returning Fri, Jul 3, priced at $324 found 1 day ago
United
Sat, Jul 18 - Sat, Jul 25
MLI
Moline
BUF
Buffalo
$325 Roundtrip, found 11 hours ago
$325
Roundtrip
found 11 hours ago
Select United flight, departing Sat, Jul 18 from Moline to Buffalo, returning Sat, Jul 25, priced at $325 found 11 hours ago
United
Wed, Jun 24 - Wed, Jul 1
MLI
Moline
BUF
Buffalo
$329 Roundtrip, found 3 days ago
$329
Roundtrip
found 3 days ago
Select United flight, departing Wed, Jun 24 from Moline to Buffalo, returning Wed, Jul 1, priced at $329 found 3 days ago
American Airlines
Wed, Jun 24 - Wed, Jul 1
MLI
Moline
BUF
Buffalo
$334 Roundtrip, found 3 days ago
$334
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jun 24 from Moline to Buffalo, returning Wed, Jul 1, priced at $334 found 3 days ago
United
Sat, Jul 18 - Sat, Jul 25
MLI
Moline
BUF
Buffalo
$337 Roundtrip, found 11 hours ago
$337
Roundtrip
found 11 hours ago
Select United flight, departing Sat, Jul 18 from Moline to Buffalo, returning Sat, Jul 25, priced at $337 found 11 hours ago
American Airlines
Sat, Oct 10 - Sat, Oct 17
MLI
Moline
BUF
Buffalo
$354 Roundtrip, found 9 hours ago
$354
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Oct 10 from Moline to Buffalo, returning Sat, Oct 17, priced at $354 found 9 hours ago
United
Sat, Oct 10 - Sat, Oct 17
MLI
Moline
BUF
Buffalo
$363 Roundtrip, found 9 hours ago
$363
Roundtrip
found 9 hours ago
Select United flight, departing Sat, Oct 10 from Moline to Buffalo, returning Sat, Oct 17, priced at $363 found 9 hours ago
Delta
Fri, Oct 16 - Mon, Oct 19
MLI
Moline
BUF
Buffalo
$398 Roundtrip, found 5 hours ago
$398
Roundtrip
found 5 hours ago
Select Delta flight, departing Fri, Oct 16 from Moline to Buffalo, returning Mon, Oct 19, priced at $398 found 5 hours ago

What you need to know for your flight from Quad City Intl. to Buffalo Niagara Intl.

Moline (MLI) to Buffalo (BUF) at a glance

Explore a range of options for flights from Moline (MLI) to Buffalo (BUF) on this domestic short-haul route. Whether you’re seeking cheap Moline to Buffalo flights or prefer full-service airlines, you can compare itineraries to find the best match for your budget and schedule. Get ready to discover Buffalo’s iconic sights and neighborhoods as you gather essential details for your journey from Quad City International Airport to Buffalo Niagara International Airport.

  • Fastest flight duration: around 3 hours in-flight, plus roughly 1h 30m layover with one stop
  • Route distance: roughly 600 miles (970 km)
  • Flights per week: around 7 departures on average
  • Typical fares (one-way): economy tickets often range from $100–$410, depending on seasonality and how far ahead you book

Flights from Quad City International Airport (MLI) to Buffalo Niagara International Airport (BUF)

Based on the latest traveler bookings, here are the top airlines favored for one-stop flights from Moline to Buffalo. Many travelers opt for layovers at O'Hare International Airport (ORD) with about a 1 hour and 30-minute stop or Charlotte-Douglas International Airport (CLT) with a roughly 1-hour layover. These choices offer you the flexibility to balance cost, total travel time, and cabin class to discover the ideal itinerary.

  • American Airlines: This major airline provides full-service, one-stop travel options, with one-way ticket prices generally falling between $100 and $405. It represents about 59% of departures for this route, featuring an in-flight duration of 3 hours and a total travel time of approximately 4 hours and 30 minutes, including layover.
  • United: Also a full-service carrier offering one-stop services, United's one-way fares typically range from $100 to $190. It accounts for around 37% of flights on this route, with a similar 3-hour flight time and a total journey duration of about 4 hours and 30 minutes, factoring in the layover.

Alternative route from Moline (MLI) to Buffalo (BUF)

  • Moline to Rochester (MLI-ROC): Greater Rochester International Airport (ROC) is located approximately 56 miles from Buffalo Niagara International Airport (BUF). One-way economy ticket prices for this route generally range from $100 to $505, influenced by the season and the timing of your booking. Flights typically include one-stop options, with common layover points at O'Hare International Airport (ORD) and Hartsfield-Jackson Atlanta International Airport (ATL). Major airlines serving this route are American Airlines and United, and first-class service is available as well.

How to find the best prices for flights from Moline (MLI) to Buffalo (BUF)

Getting some of the best deals on flights from Moline to Buffalo is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually found when booking 2 to 8 weeks in advance, which is also when most travelers make their reservations. Morning departures, between 5 AM and 12 PM, tend to offer lower prices and are popular flight times, while flying on Wednesday generally provides cheaper options, although Thursday is the most preferred travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Buffalo Niagara International Airport from Quad City International Airport

Buffalo welcomes travelers from Moline with a range of transport options based on price, convenience, and proximity. Here's how to reach Buffalo efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Buffalo, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Buffalo Niagara International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Buffalo Niagara International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From Buffalo Niagara International Airport, Buffalo-Depew Station, a train station, is located about 2.6 miles away by car, while University Station, a metro station, is situated approximately 6.5 miles away by car, providing convenient options for travelers heading into the city.

Frequently asked questions

How much does a flight from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) cost?
You can find cheap one-way flights from $269 and cheap return flights from $309 Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) with Expedia. One-way flights typically cost between $238 and $744, and return flights often range between $362 and $1286. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The cheapest month to fly from MLI to BUF is July when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Enter MLI to BUF and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.), with round-trip tickets starting from around $248 with a layover in an unspecified location. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
To find a cheap flight from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The earliest flight from Quad City International Airport (MLI) to Buffalo Niagara International Airport (BUF) usually departs at around 5:00 AM, operated by American Airlines. This seasonal service is active in May, giving you a head start on your day in Buffalo. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The most popular departure times for flights from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) are in the early morning, from 6am to 9am. About 33% of passengers prefer this time window. Many major carriers, including American Airlines and United Airlines, operate flights during this window. This timing works well because it allows you to start your day early and arrive in Buffalo with plenty of time to explore.
How long does it take to fly from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Flights from MLI to BUF with one stop typically take around 5 hours, covering approximately 611 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
First class seats are offered on the MLI to BUF route. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight with Expedia?
It's easy to earn miles on a Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Buffalo from Quad City Intl. (MLI)?
If you're planning to travel to Buffalo from Quad City Intl. (MLI), you can fly into Buffalo Niagara Intl. (BUF) Some flights may connect through major hubs like O'Hare Intl. (ORD), Hartsfield-Jackson Atlanta Intl. (ATL), Charlotte-Douglas Intl. (CLT) before reaching Buffalo. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) at the last minute?
Typically, booking a last minute flight from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight and hotel package?
Securing a Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) Buffalo Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
If you booked your Moline, IL (MLI-Quad City Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Quad City Intl.
Destination airport
Buffalo Niagara Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$308
Distance
610 mi

Book with confidence

Moline to Buffalo Flights

The cheapest times to fly from Moline to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Moline to Buffalo are during the month of July. You can find some of the cheapest flights from Moline to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Moline to Buffalo

Sunday is one of the best days to book for cheap flights from Moline to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Moline to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Moline to Buffalo in 2026. You can also book with separate airlines for your outbound and return journeys, from $269 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Moline to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Moline to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Moline to Buffalo Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

Explore a world of travel with Expedia