$179 Cheap Flights from Presque Isle (PQI) to San Diego (SAN)

View $179 flight on Thu, May 28, 2026Opens in a new window

Popular airlines from Presque Isle, ME (PQI-Northern Maine Regional) to San Diego Intl. Airport (SAN)

Cheap Flights from Presque Isle to San Diego (PQI-SAN)

Prices were available within the past 7 days and start at $179 for one-way flights and $287 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

JetBlue Airways
Fri, Oct 24 - Wed, Oct 29
PQI
Presque Isle
SAN
San Diego
$287 Roundtrip, found 1 day ago
$287
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Fri, Oct 24 from Presque Isle to San Diego, returning Wed, Oct 29, priced at $287 found 1 day ago
JetBlue Airways
Wed, Oct 29 - Thu, Oct 30
PQI
Presque Isle
SAN
San Diego
$307 Roundtrip, found 1 day ago
$307
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Wed, Oct 29 from Presque Isle to San Diego, returning Thu, Oct 30, priced at $307 found 1 day ago
JetBlue Airways
Fri, Oct 24 - Sun, Nov 2
PQI
Presque Isle
SAN
San Diego
$317 Roundtrip, found 1 day ago
$317
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Fri, Oct 24 from Presque Isle to San Diego, returning Sun, Nov 2, priced at $317 found 1 day ago
JetBlue Airways
Sat, Oct 25 - Wed, Oct 29
PQI
Presque Isle
SAN
San Diego
$327 Roundtrip, found 1 day ago
$327
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Sat, Oct 25 from Presque Isle to San Diego, returning Wed, Oct 29, priced at $327 found 1 day ago
JetBlue Airways
Thu, Oct 30 - Sun, Nov 2
PQI
Presque Isle
SAN
San Diego
$347 Roundtrip, found 1 day ago
$347
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, Oct 30 from Presque Isle to San Diego, returning Sun, Nov 2, priced at $347 found 1 day ago
JetBlue Airways
Sat, Oct 25 - Sun, Nov 2
PQI
Presque Isle
SAN
San Diego
$357 Roundtrip, found 1 day ago
$357
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Sat, Oct 25 from Presque Isle to San Diego, returning Sun, Nov 2, priced at $357 found 1 day ago
JetBlue Airways
Mon, Nov 10 - Thu, Nov 20
PQI
Presque Isle
SAN
San Diego
$581 Roundtrip, found 3 days ago
$581
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Mon, Nov 10 from Presque Isle to San Diego, returning Thu, Nov 20, priced at $581 found 3 days ago

Frequently asked questions

How much does a flight from Northern Maine Regional Airport (PQI) to San Diego Intl. Airport (SAN) cost?
Snag a cheap one-way flight from $179 or cheap return flight from $287 from Northern Maine Regional Airport (PQI) to San Diego Intl. Airport (SAN) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Northern Maine Regional Airport (PQI) to San Diego Intl. Airport (SAN)?
October is the most affordable month to fly from PQI to SAN. Traveling outside of peak seasons is often the key to finding better deals on flights.
What is the cheapest airline that flies from Northern Maine Regional Airport (PQI) to San Diego Intl. Airport (SAN)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest PQI to SAN flight.
How many flights per day from Northern Maine Regional Airport (PQI) to San Diego Intl. Airport (SAN)?
You'll have to hop on a flight with a layover if you're traveling from Northern Maine Regional Airport (PQI) to San Diego Intl. Airport (SAN). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from PQI to SAN?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Northern Maine Regional Airport (PQI) to San Diego Intl. Airport (SAN)?
To reach San Diego Intl. Airport (SAN) on time, select a flight that leaves Northern Maine Regional Airport (PQI) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Northern Maine Regional Airport (PQI) to San Diego Intl. Airport (SAN) last-minute?
Booking your flight from PQI to SAN shortly before your journey is generally more expensive. However, if there's some wiggle room with your itinerary, you could land a cheap last-minute fare.
Is it cheaper to book a PQI to SAN flight and hotel package?
Compared with arranging flights and hotels separately, booking a PQI to SAN flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one convenient place takes the hassle out of travel planning. Simply pick your flights and choose from our extensive range of stays, then personalize your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Northern Maine Regional Airport (PQI) to San Diego Intl. Airport (SAN)?
If you booked your PQI to SAN flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Northern Maine Regional
Destination airport
San Diego Intl.
Roundtrip price
$286
Distance
2733 mi

Book with confidence

Presque Isle to San Diego Flights

The cheapest times to fly from Presque Isle to San Diego

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Presque Isle to San Diego are during the month of October. You can find some of the cheapest flights from Presque Isle to San Diego with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Presque Isle to San Diego

Sunday is one of the best days to book for cheap flights from Presque Isle to San Diego: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Presque Isle to San Diego

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Presque Isle to San Diego in 2025. You can also book with separate airlines for your outbound and return journeys, from $179 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Presque Isle to San Diego flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Presque Isle to San Diego airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Presque Isle to San Diego Flights

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*Available to One Key members.