$317 Cheap Flights from Panama City (PTY) to St. Louis (STL)

View $317 flight on Wed, Feb 4, 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to St. Louis Lambert Intl. Airport (STL)

Cheap Flights from Panama City to St. Louis (PTY-STL)

Prices were available within the past 7 days and start at $317 for one-way flights and $481 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Feb 4 - Sun, Feb 8
PTY
Panama City
STL
St. Louis
$481 Roundtrip, found 4 hours ago
$481
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Feb 4 from Panama City to St. Louis, returning Sun, Feb 8, priced at $481 found 4 hours ago
American Airlines
Fri, Jan 30 - Wed, Feb 18
PTY
Panama City
STL
St. Louis
$484 Roundtrip, found 4 days ago
$484
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Jan 30 from Panama City to St. Louis, returning Wed, Feb 18, priced at $484 found 4 days ago
Delta
Wed, Feb 4 - Tue, Feb 10
PTY
Panama City
STL
St. Louis
$486 Roundtrip, found 3 days ago
$486
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Feb 4 from Panama City to St. Louis, returning Tue, Feb 10, priced at $486 found 3 days ago
Delta
Wed, Feb 4 - Sun, Feb 8
PTY
Panama City
STL
St. Louis
$489 Roundtrip, found 4 hours ago
$489
Roundtrip
found 4 hours ago
Select Delta flight, departing Wed, Feb 4 from Panama City to St. Louis, returning Sun, Feb 8, priced at $489 found 4 hours ago
Delta
Wed, Feb 4 - Tue, Feb 10
PTY
Panama City
STL
St. Louis
$495 Roundtrip, found 3 days ago
$495
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Feb 4 from Panama City to St. Louis, returning Tue, Feb 10, priced at $495 found 3 days ago
American Airlines
Fri, Jan 30 - Wed, Feb 18
PTY
Panama City
STL
St. Louis
$496 Roundtrip, found 4 days ago
$496
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Jan 30 from Panama City to St. Louis, returning Wed, Feb 18, priced at $496 found 4 days ago
American Airlines
Thu, Nov 20 - Wed, Dec 3
PTY
Panama City
STL
St. Louis
$509 Roundtrip, found 18 hours ago
$509
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Thu, Nov 20 from Panama City to St. Louis, returning Wed, Dec 3, priced at $509 found 18 hours ago
American Airlines
Sat, Jan 31 - Wed, Feb 18
PTY
Panama City
STL
St. Louis
$512 Roundtrip, found 5 days ago
$512
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Jan 31 from Panama City to St. Louis, returning Wed, Feb 18, priced at $512 found 5 days ago
United
Mon, Dec 29 - Fri, Jan 9
PTY
Panama City
STL
St. Louis
$514 Roundtrip, found 4 hours ago
$514
Roundtrip
found 4 hours ago
Select United flight, departing Mon, Dec 29 from Panama City to St. Louis, returning Fri, Jan 9, priced at $514 found 4 hours ago
Copa
Wed, Nov 5 - Mon, Nov 10
PTY
Panama City
STL
St. Louis
$709 Roundtrip, found 2 days ago
$709
Roundtrip
found 2 days ago
Select Copa flight, departing Wed, Nov 5 from Panama City to St. Louis, returning Mon, Nov 10, priced at $709 found 2 days ago

Find the cheapest month to fly from Panama City (PTY) to St. Louis (STL)

June is typically the cheapest month to fly

From $389 - $2,019 per traveler.

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $617
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $617

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Lambert-St. Louis Intl. Airport (STL) cost?
Get a cheap one-way flight from $317 or cheap return flight from $481 from Tocumen Intl. Airport (PTY) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Lambert-St. Louis Intl. Airport (STL)?
The cheapest month to fly from PTY to STL is February, when demand is low. Off-peak months are generally when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Lambert-St. Louis Intl. Airport (STL)?
To find the cheapest airline flying from PTY to STL, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Tocumen Intl. Airport (PTY) to Lambert-St. Louis Intl. Airport (STL)?
Direct flights from Tocumen Intl. Airport (PTY) to Lambert-St. Louis Intl. Airport (STL) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel details and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from PTY to STL?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary based on a range of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Lambert-St. Louis Intl. Airport (STL)?
To avoid possible delays on the Tocumen Intl. Airport (PTY) to Lambert-St. Louis Intl. Airport (STL) route, travel before 3 PM. Later flights have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Booking your plane ticket from PTY to STL shortly before your getaway is generally more expensive. But if you're flexible with your travel dates and times, you could grab a cheap last-minute fare.
Is it cheaper to book a PTY to STL flight and hotel package?
You'll generally save money by booking a PTY to STL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. Once you've chosen your preferred accommodations and flights, consider adding extras including activities, tours and car rentals.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Lambert-St. Louis Intl. Airport (STL)?
Generally, it's possible to reschedule or cancel your PTY to STL flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Origin airport
Tocumen Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$480
Distance
2160 mi

Book with confidence

Panama City to St. Louis Flights

The cheapest times to fly from Panama City to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to St. Louis are during the month of February. You can find some of the cheapest flights from Panama City to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to St. Louis

Sunday is one of the best days to book for cheap flights from Panama City to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $317 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Panama City to St. Louis Flights

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*Available to One Key members.