$159 Cheap Flights from Syracuse (SYR) to St. Louis (STL)

View $159 flight on Mon, Jan 12, 2026Opens in a new window

Popular airlines from Hancock Intl. Airport (SYR) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Syracuse to St. Louis (SYR-STL)

Prices were available within the past 7 days and start at $159 for one-way flights and $190 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Thu, Oct 16 - Fri, Oct 24
SYR
Syracuse
STL
St. Louis
$190 Roundtrip, found 1 day ago
$190
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Oct 16 from Syracuse to St. Louis, returning Fri, Oct 24, priced at $190 found 1 day ago
Frontier Airlines
Thu, Oct 16 - Sat, Oct 18
SYR
Syracuse
STL
St. Louis
$206 Roundtrip, found 1 day ago
$206
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Oct 16 from Syracuse to St. Louis, returning Sat, Oct 18, priced at $206 found 1 day ago
Frontier Airlines
Sun, Nov 2 - Sat, Nov 8
SYR
Syracuse
STL
St. Louis
$213 Roundtrip, found 4 hours ago
$213
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Sun, Nov 2 from Syracuse to St. Louis, returning Sat, Nov 8, priced at $213 found 4 hours ago
Frontier Airlines
Thu, Oct 16 - Sat, Nov 1
SYR
Syracuse
STL
St. Louis
$229 Roundtrip, found 1 day ago
$229
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Oct 16 from Syracuse to St. Louis, returning Sat, Nov 1, priced at $229 found 1 day ago
Frontier Airlines
Sun, Oct 12 - Fri, Oct 17
SYR
Syracuse
STL
St. Louis
$238 Roundtrip, found 6 days ago
$238
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sun, Oct 12 from Syracuse to St. Louis, returning Fri, Oct 17, priced at $238 found 6 days ago
Frontier Airlines
Sat, Oct 18 - Fri, Oct 24
SYR
Syracuse
STL
St. Louis
$244 Roundtrip, found 1 day ago
$244
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Oct 18 from Syracuse to St. Louis, returning Fri, Oct 24, priced at $244 found 1 day ago
American Airlines
Thu, Nov 13 - Mon, Nov 17
SYR
Syracuse
STL
St. Louis
$249 Roundtrip, found 3 hours ago
$249
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Thu, Nov 13 from Syracuse to St. Louis, returning Mon, Nov 17, priced at $249 found 3 hours ago
Delta
Fri, Oct 17 - Mon, Oct 20
SYR
Syracuse
STL
St. Louis
$249 Roundtrip, just found
$249
Roundtrip
just found
Select Delta flight, departing Fri, Oct 17 from Syracuse to St. Louis, returning Mon, Oct 20, priced at $249 just found
Delta
Tue, Nov 18 - Wed, Nov 26
SYR
Syracuse
STL
St. Louis
$251 Roundtrip, found 5 days ago
$251
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Nov 18 from Syracuse to St. Louis, returning Wed, Nov 26, priced at $251 found 5 days ago
United
Wed, Oct 1 - Wed, Oct 8
SYR
Syracuse
STL
St. Louis
$254 Roundtrip, found 5 hours ago
$254
Roundtrip
found 5 hours ago
Select United flight, departing Wed, Oct 1 from Syracuse to St. Louis, returning Wed, Oct 8, priced at $254 found 5 hours ago

Find the cheapest month to fly from Syracuse (SYR) to St. Louis (STL)

December is typically the cheapest month to fly

From $189 - $562 per traveler.

Frequently asked questions

How much does a flight from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL) cost?
Get a cheap one-way flight from $159 or cheap return flight from $190 from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL)?
October is the most affordable month to fly from SYR to STL. Avoiding peak travel times is often the key to scoring lower fares.
What is the cheapest airline that flies from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll take you from SYR to STL. Then, sort your results by "Price (lowest to highest)" to score a good deal.
How many flights per day from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL)?
You'll have to hop on a flight with a layover when traveling from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from SYR to STL?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL)?
To land at Lambert-St. Louis Intl. Airport (STL) on time, choose a flight that leaves Hancock Intl. Airport (SYR) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Booking your plane ticket from SYR to STL shortly before your trip is usually more expensive. However, if you're flexible with your schedule, you could grab a cheap last-minute fare.
Is it cheaper to book a SYR to STL flight and hotel package?
Booking a SYR to STL flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Select from our impressive range of stays and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL)?
Typically, you can cancel or reschedule your SYR to STL flight. However, additional charges may apply, especially if you booked more than 24 hours ago. Check your itinerary for the airline's fees and policies on flight changes, or if you want further information, visit our Customer Service portal.

Travel information

Travel information

Origin airport
Hancock Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, United
Roundtrip price
$190
Distance
801 mi

Book with confidence

Book with confidence

Syracuse to St. Louis Flights

The cheapest times to fly from Syracuse to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Syracuse to St. Louis are during the month of October. You can find some of the cheapest flights from Syracuse to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Syracuse to St. Louis

Sunday is one of the best days to book for cheap flights from Syracuse to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Syracuse to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Syracuse to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $159 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Syracuse to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Syracuse to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Syracuse to St. Louis Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.