$338 Cheap Flights from Tampico (TAM) to Knoxville (TYS)

View $338 flight on Wed, Oct 22, 2025Opens in a new window

Popular airlines from Tampico, Tamaulipas (TAM-General Francisco Javier Mina Intl.) to McGhee Tyson Airport (TYS)

Cheap Flights from Tampico to Knoxville (TAM-TYS)

Prices were available within the past 7 days and start at $338 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from General Francisco Javier Mina Intl. Airport (TAM) to McGhee Tyson Airport (TYS) cost?
Secure a cheap one-way flight from $338 or cheap return flight from General Francisco Javier Mina Intl. Airport (TAM) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from General Francisco Javier Mina Intl. Airport (TAM) to McGhee Tyson Airport (TYS)?
Planning your getaway for can help you save, as it's the cheapest month for flights between TAM and TYS. You'll typically find the lowest fares during off-peak months.
What is the cheapest airline that flies from General Francisco Javier Mina Intl. Airport (TAM) to McGhee Tyson Airport (TYS)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll fly you from TAM to TYS. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from General Francisco Javier Mina Intl. Airport (TAM) to McGhee Tyson Airport (TYS)?
There are no daily direct flights departing from General Francisco Javier Mina Intl. Airport (TAM) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from TAM to TYS?
Usually you'll find the widest variety of flight choices on a Friday. Tuesdays are often the quietest.* But this can change depending on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from General Francisco Javier Mina Intl. Airport (TAM) to McGhee Tyson Airport (TYS)?
To avoid potential delays on the General Francisco Javier Mina Intl. Airport (TAM) to McGhee Tyson Airport (TYS) route, fly before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from General Francisco Javier Mina Intl. Airport (TAM) to McGhee Tyson Airport (TYS) last-minute?
Holding off until right before your break to book a ticket from TAM to TYS generally means paying more. Although you may find some last-minute offers, they aren't always guaranteed. Allow some flexibility in your schedule for a better chance of landing a bargain.
Is it cheaper to book a TAM to TYS flight and hotel package?
Opting for a TAM to TYS flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Choose from our wide range of hotels and then add car rentals, flights and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from General Francisco Javier Mina Intl. Airport (TAM) to McGhee Tyson Airport (TYS)?
Generally, it's possible to reschedule or cancel your TAM to TYS flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Travel information

Origin airport
General Francisco Javier Mina Intl.
Destination airport
McGhee Tyson
Distance
1252 mi

Book with confidence

Book with confidence

Tampico to Knoxville Flights

The cheapest times to fly from Tampico to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tampico to Knoxville are during the month of . You can find some of the cheapest flights from Tampico to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tampico to Knoxville

Sunday is one of the best days to book for cheap flights from Tampico to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tampico to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tampico to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $338 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tampico to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tampico to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Tampico to Knoxville Flights

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Explore a world of travel with Expedia

*Available to One Key members.