$314 Cheap Flights from Tupelo (TUP) to St. Louis (STL)

View $314 flight on Tue, Nov 11, 2025Opens in a new window

Popular airlines from Tupelo, MS (TUP-Tupelo Regional) to St. Louis Lambert Intl. Airport (STL)

Cheap Flights from Tupelo to St. Louis (TUP-STL)

Prices were available within the past 7 days and start at $314 for one-way flights and $335 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Contour Airlines
Mon, Dec 15 - Tue, Dec 16
TUP
Tupelo
STL
St. Louis
$335 Roundtrip, found 5 hours ago
$335
Roundtrip
found 5 hours ago
Select Contour Airlines flight, departing Mon, Dec 15 from Tupelo to St. Louis, returning Tue, Dec 16, priced at $335 found 5 hours ago
Contour Airlines
Sat, Dec 13 - Mon, Dec 15
TUP
Tupelo
STL
St. Louis
$360 Roundtrip, found 5 hours ago
$360
Roundtrip
found 5 hours ago
Select Contour Airlines flight, departing Sat, Dec 13 from Tupelo to St. Louis, returning Mon, Dec 15, priced at $360 found 5 hours ago
Contour Airlines
Mon, Dec 15 - Tue, Dec 16
TUP
Tupelo
STL
St. Louis
$368 Roundtrip, found 5 hours ago
$368
Roundtrip
found 5 hours ago
Select Contour Airlines flight, departing Mon, Dec 15 from Tupelo to St. Louis, returning Tue, Dec 16, priced at $368 found 5 hours ago
Contour Airlines
Tue, Dec 16 - Thu, Dec 25
TUP
Tupelo
STL
St. Louis
$376 Roundtrip, found 5 hours ago
$376
Roundtrip
found 5 hours ago
Select Contour Airlines flight, departing Tue, Dec 16 from Tupelo to St. Louis, returning Thu, Dec 25, priced at $376 found 5 hours ago
Contour Airlines
Mon, Dec 15 - Tue, Dec 16
TUP
Tupelo
STL
St. Louis
$385 Roundtrip, found 5 hours ago
$385
Roundtrip
found 5 hours ago
Select Contour Airlines flight, departing Mon, Dec 15 from Tupelo to St. Louis, returning Tue, Dec 16, priced at $385 found 5 hours ago
Contour Airlines
Tue, Dec 2 - Wed, Dec 3
TUP
Tupelo
STL
St. Louis
$398 Roundtrip, found 1 day ago
$398
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Tue, Dec 2 from Tupelo to St. Louis, returning Wed, Dec 3, priced at $398 found 1 day ago
Contour Airlines
Wed, Dec 17 - Thu, Dec 25
TUP
Tupelo
STL
St. Louis
$401 Roundtrip, found 5 hours ago
$401
Roundtrip
found 5 hours ago
Select Contour Airlines flight, departing Wed, Dec 17 from Tupelo to St. Louis, returning Thu, Dec 25, priced at $401 found 5 hours ago
Contour Airlines
Mon, Dec 15 - Tue, Dec 16
TUP
Tupelo
STL
St. Louis
$410 Roundtrip, found 5 hours ago
$410
Roundtrip
found 5 hours ago
Select Contour Airlines flight, departing Mon, Dec 15 from Tupelo to St. Louis, returning Tue, Dec 16, priced at $410 found 5 hours ago
Contour Airlines
Tue, Dec 16 - Sun, Dec 21
TUP
Tupelo
STL
St. Louis
$413 Roundtrip, found 5 hours ago
$413
Roundtrip
found 5 hours ago
Select Contour Airlines flight, departing Tue, Dec 16 from Tupelo to St. Louis, returning Sun, Dec 21, priced at $413 found 5 hours ago
Contour Airlines
Sun, Dec 14 - Mon, Dec 15
TUP
Tupelo
STL
St. Louis
$424 Roundtrip, found 5 hours ago
$424
Roundtrip
found 5 hours ago
Select Contour Airlines flight, departing Sun, Dec 14 from Tupelo to St. Louis, returning Mon, Dec 15, priced at $424 found 5 hours ago

Frequently asked questions

How much does a flight from Tupelo Regional Airport (TUP) to Lambert-St. Louis Intl. Airport (STL) cost?
Get a cheap one-way flight from $314 or cheap return flight from $335 from Tupelo Regional Airport (TUP) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Tupelo Regional Airport (TUP) to Lambert-St. Louis Intl. Airport (STL)?
Traveling in December is a great way to save, as it's the cheapest month for flights between TUP and STL. You'll usually find the lowest fares during off-peak months.
What is the cheapest airline that flies from Tupelo Regional Airport (TUP) to Lambert-St. Louis Intl. Airport (STL)?
To find the cheapest airline flying from TUP to STL, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Tupelo Regional Airport (TUP) to Lambert-St. Louis Intl. Airport (STL)?
There are no daily nonstop flights departing from Tupelo Regional Airport (TUP) to Lambert-St. Louis Intl. Airport (STL). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from TUP to STL?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can change based on a range of factors, such as the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tupelo Regional Airport (TUP) to Lambert-St. Louis Intl. Airport (STL)?
Select a flight from Tupelo Regional Airport (TUP) to Lambert-St. Louis Intl. Airport (STL) that takes off before 3 PM to reduce the likelihood of delays. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tupelo Regional Airport (TUP) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Waiting until just before your departure to book a flight from TUP to STL often results in higher prices. Although you may find some last-minute offers, they're not always guaranteed. Be flexible with your travel plans for the best chance of scoring a bargain.
Is it cheaper to book a TUP to STL flight and hotel package?
Compared with arranging hotels and flights separately, booking a TUP to STL flight and hotel package with Expedia could result in significant savings. Better yet, having it all in one place will take the stress out of travel planning. Just secure your flights and choose from our extensive range of hotels, then personalize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Tupelo Regional Airport (TUP) to Lambert-St. Louis Intl. Airport (STL)?
You can usually cancel or reschedule your TUP to STL flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Origin airport
Tupelo Regional
Destination airport
Lambert-St. Louis Intl.
Roundtrip price
$335
Distance
321 mi

Book with confidence

Tupelo to St. Louis Flights

The cheapest times to fly from Tupelo to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tupelo to St. Louis are during the month of December. You can find some of the cheapest flights from Tupelo to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tupelo to St. Louis

Sunday is one of the best days to book for cheap flights from Tupelo to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tupelo to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tupelo to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $314 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tupelo to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tupelo to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Tupelo to St. Louis Flights

Explore a world of travel with Expedia

*Available to One Key members.