$224 Cheap American Airlines flights Detroit (DTW) to San Diego (SAN)

Scoring cheap one-way American Airlines flights from DTW to SAN from $224 on Expedia is easy — just filter by "Price (lowest to highest)." Or check out our affordable round-trip fares from $315 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for cheap American Airlines flights from Detroit Metropolitan Wayne County Airport (DTW) to San Diego Intl. Airport (SAN) one to three months prior to your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and itinerary, the best day to book a domestic flight is usually Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departure from DTW to SAN with American Airlines, filter your results by "Morning" and "Early Morning." Choosing an early flight generally means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.