$187 Cheap American Airlines flights Indianapolis (IND) to San Francisco (SFO)

Landing cheap one-way American Airlines flights from IND to SFO from $187 on Expedia couldn't be easier — just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly round-trip fares from $289 for your next exciting getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for affordable American Airlines flights from Indianapolis Intl. Airport (IND) to San Francisco Intl. Airport (SFO) one to three months prior to your departure date. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and itinerary, the best day of the week to book a domestic flight is usually Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Morning" and "Early Morning" to browse the earliest flights from IND to SFO. Setting off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.