$138 Cheap American Airlines flights St. Louis (STL) to San Francisco (SFO)

Use the “Price (lowest to highest)” filter on Expedia to find cheap American Airlines round-trip flights from $214 from STL to SFO. Affordable one-way options from $138 are available too.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

February is one of the least expensive months to fly to San Francisco with American Airlines. You could also find fantastic deals on one-way and return fares in April.

Search for cheap American Airlines flights from Lambert-St. Louis Intl. Airport (STL) to San Francisco Intl. Airport (SFO) one to three months before your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and journey, the best day to book a domestic flight is usually Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Enter your dates, click search and use the “Nonstop” filter on Expedia to browse any direct flights from STL to SFO with American Airlines or another airline.

Search American Airlines’s earliest flights from STL to SFO by selecting the “Morning” and “Early Morning” filters. Not only will you get to your destination sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Get on an American Airlines flight from Lambert-St. Louis Intl. Airport (STL) to San Francisco, and you’ll likely come in to San Francisco Intl. Airport (SFO). This is the airline’s primary hub in this city.

Changes are often free within 24 hours of booking, but your airline may add a charge after that. For more details about modifying your flights, check out your “Trips,” select your flight and click on “Manage Booking.” If you want the freedom to make changes without extra charges, tick the “No cancel fee” or “Changes included” filter when planning your next adventure.