$165 Cheap American Airlines flights Knoxville (TYS) to San Francisco (SFO)

You can find affordable round-trip American Airlines flights from $234 from TYS to SFO by filtering your results from "Price (lowest to highest)" on Expedia. Or search for bargains from $165 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Start searching one to three months before your departure to score cheaper fares on American Airlines flights from McGhee Tyson Airport (TYS) to San Francisco Intl. Airport (SFO). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Nail your timing, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departure from TYS to SFO with American Airlines, sort your results by "Morning" and "Early Morning." Choosing an early flight generally means you'll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.