$105 Cheap American Airlines flights Orlando (MCO) to San Diego (SAN)

Finding cheap one-way American Airlines flights from MCO to SAN from $105 on Expedia is a cinch — just filter by “Price (lowest to highest).” Alternatively, check out our affordable return fares from $209 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the cheapest months to jet off to San Diego with American Airlines. You could also find great prices on one-way and return tickets in November.

Start searching one to three months ahead of your departure date to get cheap fares on American Airlines flights from Orlando Intl. Airport (MCO) to San Diego Intl. Airport (SAN). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing spot on, and you can enjoy significant savings on domestic journeys.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Click on the “Nonstop” filter when browsing for direct American Airlines flights from MCO to SAN. It’s also an easy way to compare other carriers servicing the same direct trip.

To find the earliest departure from MCO to SAN with American Airlines, filter your results by “Early Morning” and “Morning.” Choosing an early flight generally means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Orlando Intl. Airport (MCO) to San Diego land at San Diego Intl. Airport (SAN). This is the main gateway to this city.

Depending on your ticket type, a fee typically applies if you cancel or reschedule your booking more than 24 hours after it’s confirmed. To secure flexible plane tickets, select our “No cancel fee” or “Changes included” filter when searching for flights. To learn more about changing or canceling your reservation, visit “Trips,” select your flight and click on “Manage Booking.”