$139 Cheap American Airlines flights Raleigh (RDU) to San Diego (SAN)

Landing cheap one-way American Airlines flights from RDU to SAN from $139 on Expedia couldn’t be easier — just filter by “Price (lowest to highest).” Alternatively, check out our budget-friendly return fares from $271 for your next adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to San Diego are generally cheaper in the off-peak months of January and November. Whether you’re searching for a one-way or a return ticket, you could score a better deal then.

To find cheap American Airlines fares from Raleigh - Durham Intl. Airport (RDU) to San Diego Intl. Airport (SAN), start searching one to three months before your planned departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also influence the overall price. Sunday is generally the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by choosing to book on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Enter your dates, hit search and use the “Nonstop” filter on Expedia to browse any direct flights from RDU to SAN with American Airlines or another carrier.

Filter your results by “Early Morning” and “Morning” to browse the earliest departures from RDU to SAN. Taking off early means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

San Diego Intl. Airport (SAN) is the primary San Diego hub for American Airlines flights from Raleigh - Durham Intl. Airport (RDU).

Depending on the type of ticket you purchased, a fee is typically charged if you cancel or change your flight more than 24 hours after it’s been confirmed. To secure plane tickets with more flexibility, select our “No cancel fee” or “Changes included” filter when searching for flights. For more information on modifying or canceling your reservation, visit “Trips,” select your flight and click on “Manage Booking.”