$355 Cheap American Airlines flights Panama City (PTY) to San Diego (SAN)

Set the "Price (lowest to highest)" filter on Expedia to search for cheap American Airlines round-trip flights from $375 from PTY to SAN. Affordable one-way tickets from $355 are also available.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To get cheap flights from PTY to SAN with American Airlines, begin your search about one month before your planned departure. You can save 17% when you lock in your international tickets 18 to 29 days ahead instead of booking four to five months in advance. Another helpful tip? Booking on Sunday can lead to average savings of 17% compared to Friday (the most expensive day).**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departures from PTY to SAN with American Airlines, sort your results by "Morning" and "Early Morning." Choosing an early flight generally means you'll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.