$1,771 Cheap Brussels Airlines flights Lyon (LYS) to San Diego (SAN)

Apply the "Price (lowest to highest)" filter on Expedia to search for cheap Brussels Airlines round-trip flights from $1,418 from LYS to SAN. Affordable one-way options from $1,771 are available as well.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To find affordable flights from LYS to SAN with Brussels Airlines, start searching about one month before your planned departure. You can save 17% when you lock in your international tickets 18 to 29 days ahead instead of booking four to five months in advance. Another tip? Booking on Sunday can lead to average savings of 17% compared to Friday (the most expensive day).**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Browse Brussels Airlines's earliest flights from LYS to SAN by using the "Morning" and "Early Morning" filters. Not only will you arrive sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Offering a rewarding loyalty program, Brussels Airlines is a top pick for many travelers journeying from LYS to SAN. Plus, if you're a Miles and More and One Key™ member booking through Expedia, you can earn OneKeyCash™* on eligible flights on top of your airline miles.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.