$222 Cheap Delta flights Mexico City (MEX) to San Francisco (SFO)

Landing cheap one-way Delta Air Lines flights from MEX to SFO from $222 on Expedia is simple --- just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly round-trip fares from $299 for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To discover affordable flights from MEX to SFO with Delta Air Lines, start your search about one month before your intended departure. You can save 17% when you lock in your international tickets 18 to 29 days ahead instead of booking four to five months in advance. Another useful tip? Booking on Sunday offers average savings of 17% compared to Friday (the most expensive day).**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departure from MEX to SFO with Delta Air Lines, sort your results by "Morning" and "Early Morning." Choosing an early flight generally means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Delta Air Lines makes traveling from MEX to SFO more comfortable with a rewarding loyalty program and an excellent in-flight experience. You even have the chance to collect points with Delta SkyMiles. Remember to sign up to Expedia's free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future travel.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.