$444 Cheap Flights from Brussels (BRU) to Knoxville (TYS)

View $444 flight on Thu, Feb 12, 2026Opens in a new window

Popular airlines from Brussels Airport (BRU) to McGhee Tyson Airport (TYS)

Cheap Flights from Brussels to Knoxville (BRU-TYS)

Prices were available within the past 7 days and start at $444 for one-way flights and $669 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

British Airways
Wed, Dec 3 - Wed, Dec 10
BRU
Brussels
TYS
Knoxville
$669 Roundtrip, found 6 days ago
$669
Roundtrip
found 6 days ago
Select British Airways flight, departing Wed, Dec 3 from Brussels to Knoxville, returning Wed, Dec 10, priced at $669 found 6 days ago
American Airlines
Sun, Jan 11 - Mon, Jan 26
BRU
Brussels
TYS
Knoxville
$690 Roundtrip, found 5 days ago
$690
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sun, Jan 11 from Brussels to Knoxville, returning Mon, Jan 26, priced at $690 found 5 days ago
American Airlines
Tue, Dec 9 - Tue, Dec 23
BRU
Brussels
TYS
Knoxville
$696 Roundtrip, found 5 days ago
$696
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Dec 9 from Brussels to Knoxville, returning Tue, Dec 23, priced at $696 found 5 days ago
American Airlines
Wed, Dec 24 - Tue, Jan 6
BRU
Brussels
TYS
Knoxville
$701 Roundtrip, found 5 days ago
$701
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Dec 24 from Brussels to Knoxville, returning Tue, Jan 6, priced at $701 found 5 days ago
British Airways
Mon, Dec 8 - Mon, Dec 15
BRU
Brussels
TYS
Knoxville
$712 Roundtrip, found 1 day ago
$712
Roundtrip
found 1 day ago
Select British Airways flight, departing Mon, Dec 8 from Brussels to Knoxville, returning Mon, Dec 15, priced at $712 found 1 day ago
British Airways
Fri, Nov 7 - Wed, Nov 19
BRU
Brussels
TYS
Knoxville
$724 Roundtrip, found 6 days ago
$724
Roundtrip
found 6 days ago
Select British Airways flight, departing Fri, Nov 7 from Brussels to Knoxville, returning Wed, Nov 19, priced at $724 found 6 days ago
British Airways
Wed, Dec 24 - Wed, Jan 7
BRU
Brussels
TYS
Knoxville
$727 Roundtrip, found 5 days ago
$727
Roundtrip
found 5 days ago
Select British Airways flight, departing Wed, Dec 24 from Brussels to Knoxville, returning Wed, Jan 7, priced at $727 found 5 days ago
Air Canada
Tue, Feb 24 - Sat, Mar 7
BRU
Brussels
TYS
Knoxville
$751 Roundtrip, found 6 days ago
$751
Roundtrip
found 6 days ago
Select Air Canada flight, departing Tue, Feb 24 from Brussels to Knoxville, returning Sat, Mar 7, priced at $751 found 6 days ago
United
Fri, Nov 7 - Sun, Nov 16
BRU
Brussels
TYS
Knoxville
$753 Roundtrip, found 6 days ago
$753
Roundtrip
found 6 days ago
Select United flight, departing Fri, Nov 7 from Brussels to Knoxville, returning Sun, Nov 16, priced at $753 found 6 days ago
Delta
Tue, Nov 4 - Fri, Nov 21
BRU
Brussels
TYS
Knoxville
$765 Roundtrip, found 6 days ago
$765
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Nov 4 from Brussels to Knoxville, returning Fri, Nov 21, priced at $765 found 6 days ago

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $751
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $751

Frequently asked questions

How much does a flight from Brussels - National Airport (BRU) to McGhee Tyson Airport (TYS) cost?
Grab a cheap one-way flight from $444 or cheap return flight from $669 from Brussels - National Airport (BRU) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Brussels - National Airport (BRU) to McGhee Tyson Airport (TYS)?
December is the most affordable month to fly from BRU to TYS. Avoiding peak travel times is often the key to better flight prices.
What is the cheapest airline that flies from Brussels - National Airport (BRU) to McGhee Tyson Airport (TYS)?
To find the cheapest airline that'll fly you from BRU to TYS, use Expedia's filter tool. Tailor your search based on your travel needs, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Brussels - National Airport (BRU) to McGhee Tyson Airport (TYS)?
You'll need to hop on a flight with a layover when traveling from Brussels - National Airport (BRU) to McGhee Tyson Airport (TYS). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from BRU to TYS?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Brussels - National Airport (BRU) to McGhee Tyson Airport (TYS)?
To avoid potential delays on the Brussels - National Airport (BRU) to McGhee Tyson Airport (TYS) route, fly before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Brussels - National Airport (BRU) to McGhee Tyson Airport (TYS) last-minute?
Last-minute bookings from BRU to TYS are typically more expensive. To lock in the best prices, start searching for flights early. That being said, if your travel plans are flexible, you may land a cheap fare just before your departure.
Is it cheaper to book a BRU to TYS flight and hotel package?
You'll typically save money by booking a BRU to TYS flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. After choosing your ideal flights and accommodations, consider adding extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Brussels - National Airport (BRU) to McGhee Tyson Airport (TYS)?
If you reserved your BRU to TYS flight in the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

Travel information

Origin airport
Brussels - National
Destination airport
McGhee Tyson
Roundtrip price
$669
Distance
4291 mi

Book with confidence

Brussels to Knoxville Flights

The cheapest times to fly from Brussels to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Brussels to Knoxville are during the month of December. You can find some of the cheapest flights from Brussels to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Brussels to Knoxville

Sunday is one of the best days to book for cheap flights from Brussels to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Brussels to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Brussels to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $444 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Brussels to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Brussels to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Brussels to Knoxville Flights

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*Available to One Key members.