Title: Cleveland to Florence cheap flights from $227 (CLE to FLO) - Expedia.com ![Florence. Italy. Panorama of Florence on a sunny day.](https://images.trvl-media.com/place/1221/374d4531-94f4-49c0-ae64-4d3f066e98eb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/1221/374d4531-94f4-49c0-ae64-4d3f066e98eb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # $227 Cheap Flights from Cleveland (CLE) to Florence (FLO) [View $227 flight on Wed, Jun 17, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:CLE,to:FLO,departure:6/17/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:226.10&airProductToken=AQqbAQoxCMGCARIENjM2MxjiIiCuHCj4-Y8DMOT6jwM4QkAAWAFqBUJBU0lDcghPVkFJS1NCWAoyCMGCARIEMTY4MxiuHCDimgEo2f2PAzDj_o8DOEJAAVgBagVCQVNJQ3IIT1dBV1hOQlgKMgjBggESBDU4OTMY4poBIOVyKJf_jwMw2P-PAzhCQAFYAWoFQkFTSUNyCE9XQVdYTkJYEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) ## Popular airlines from Cleveland Hopkins International Airport (CLE) to Florence, SC (FLO-Florence Regional) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines [](https://www.expedia.com/Flights-Search?leg1=from:CLE,to:FLO,departure:4/22/2026TANYT&leg2=from:FLO,to:CLE,departure:4/29/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## Cheap Flights from Cleveland to Florence (CLE-FLO) Prices were available within the past 7 days and start at $227 for one-way flights and $455 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, Jun 17 - Mon, Jun 29 CLE Cleveland FLO Florence $455 Roundtrip found 10 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CLE,to:FLO,departure:6/17/2026TANYT&leg2=from:FLO,to:CLE,departure:6/29/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:454.70&airProductToken=AQqbAQoxCMGCARIENjM2MxjiIiCuHCj4-Y8DMOT6jwM4QkAAWAFqBUJBU0lDcghPVkFJS1NCWAoyCMGCARIEMTY4MxiuHCDimgEo2f2PAzDj_o8DOEJAAVgBagVCQVNJQ3IIT1dGV1VOQlYKMgjBggESBDU4OTMY4poBIOVyKJf_jwMw2P-PAzhCQAFYAWoFQkFTSUNyCE9XRldVTkJWCmgKMgjBggESBDYwNzcY5XIg4poBKJuDkQMw4IORAzhCQABYAWoFQkFTSUNyCE9XRldaTkJaCjIIwYIBEgQxNjc5GOKaASDiIiiphJEDMI6FkQM4QkABWAFqBUJBU0lDcghPV0ZXWk5CWhIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, Jun 17 - Mon, Jun 29 CLE Cleveland FLO Florence $460 Roundtrip found 10 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CLE,to:FLO,departure:6/17/2026TANYT&leg2=from:FLO,to:CLE,departure:6/29/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:460.00&airProductToken=AQqbAQoxCMGCARIENjM2MxjiIiCuHCj4-Y8DMOT6jwM4QkAAWAFqBUJBU0lDcghPVkFJS1NCWAoyCMGCARIEMTY4MxiuHCDimgEo2f2PAzDj_o8DOEJAAVgBagVCQVNJQ3IIT1dGV1VOQlYKMgjBggESBDU4OTMY4poBIOVyKJf_jwMw2P-PAzhCQAFYAWoFQkFTSUNyCE9XRldVTkJWCpsBCjIIwYIBEgQ2MDA0GOVyIOKaASjh_pADMKD_kAM4QkAAWAFqBUJBU0lDcghPV0ZXWk5CWgoyCMGCARIEMjg0MxjimgEgrhwogICRAzCKgZEDOEJAAVgBagVCQVNJQ3IIT1dGV1pOQloKMQjBggESBDQ5NDkYrhwg4iIonoKRAzD8gpEDOEJAAVgBagVCQVNJQ3IIT1dGV1pOQloSCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, Jun 17 - Mon, Jun 29 CLE Cleveland FLO Florence $487 Roundtrip found 10 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CLE,to:FLO,departure:6/17/2026TANYT&leg2=from:FLO,to:CLE,departure:6/29/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:487.00&airProductToken=AQqbAQoxCMGCARIENjM2MxjiIiCuHCj4-Y8DMOT6jwM4QkAAWAFqBUJBU0lDcghPVkFJS1NCWAoyCMGCARIEMTY4MxiuHCDimgEo2f2PAzDj_o8DOEJAAVgBagVCQVNJQ3IIT1dGV1VOQlYKMgjBggESBDU4OTMY4poBIOVyKJf_jwMw2P-PAzhCQAFYAWoFQkFTSUNyCE9XRldVTkJWCpsBCjIIwYIBEgQ2MDA0GOVyIOKaASjh_pADMKD_kAM4QkAAWAFqBUJBU0lDcghPV0ZXWk5CWAoyCMGCARIEMTAzOBjimgEgrhwo6oCRAzDzgZEDOEJAAVgBagVCQVNJQ3IIT1dGV1pOQlgKMQjBggESBDQ5MDkYrhwg4iIo9oORAzDYhJEDOEJAAVgBagVCQVNJQ3IITldBSVpOQloSCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, Jun 17 - Mon, Jun 29 CLE Cleveland FLO Florence $508 Roundtrip found 10 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CLE,to:FLO,departure:6/17/2026TANYT&leg2=from:FLO,to:CLE,departure:6/29/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:507.40&airProductToken=AQpoCjIIwYIBEgQyMDIxGOIiIOKaASiZ-Y8DMIP6jwM4QkAAWAFqBUJBU0lDcghPV0ZXVU5CWgoyCMGCARIENjA3NxjimgEg5XIowfuPAzCC_I8DOEJAAVgBagVCQVNJQ3IIT1dGV1VOQloKaAoyCMGCARIENjAwNBjlciDimgEo4f6QAzCg_5ADOEJAAFgBagVCQVNJQ3IIT1dGV1pOQloKMgjBggESBDE2NzcY4poBIOIiKPGAkQMw1YGRAzhCQAFYAWoFQkFTSUNyCE9XRldaTkJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, Jun 17 - Mon, Jun 29 CLE Cleveland FLO Florence $513 Roundtrip found 10 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CLE,to:FLO,departure:6/17/2026TANYT&leg2=from:FLO,to:CLE,departure:6/29/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:512.70&airProductToken=AQqbAQoxCMGCARIEMTMxNRjiIiCuHCiY-I8DMPr4jwM4QkAAWAFqBUJBU0lDcghPV0ZXVU5CWgoyCMGCARIEMzIyMhiuHCDimgEoyvmPAzDN-o8DOEJAAVgBagVCQVNJQ3IIT1dGV1VOQloKMgjBggESBDYwNzcY4poBIOVyKMH7jwMwgvyPAzhCQAFYAWoFQkFTSUNyCE9XRldVTkJaCmgKMgjBggESBDYwMDQY5XIg4poBKOH-kAMwoP-QAzhCQABYAWoFQkFTSUNyCE9XRldaTkJaCjIIwYIBEgQxNjc3GOKaASDiIijxgJEDMNWBkQM4QkABWAFqBUJBU0lDcghPV0ZXWk5CWhIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, Jun 17 - Mon, Jun 29 CLE Cleveland FLO Florence $518 Roundtrip found 10 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CLE,to:FLO,departure:6/17/2026TANYT&leg2=from:FLO,to:CLE,departure:6/29/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:518.00&airProductToken=AQqbAQoxCMGCARIEMTMxNRjiIiCuHCiY-I8DMPr4jwM4QkAAWAFqBUJBU0lDcghPV0ZXVU5CWgoyCMGCARIEMzIyMhiuHCDimgEoyvmPAzDN-o8DOEJAAVgBagVCQVNJQ3IIT1dGV1VOQloKMgjBggESBDYwNzcY4poBIOVyKMH7jwMwgvyPAzhCQAFYAWoFQkFTSUNyCE9XRldVTkJaCpsBCjIIwYIBEgQ2MDA0GOVyIOKaASjh_pADMKD_kAM4QkAAWAFqBUJBU0lDcghPV0ZXWk5CWgoyCMGCARIEMTAzOBjimgEgrhwo6oCRAzDzgZEDOEJAAVgBagVCQVNJQ3IIT1dGV1pOQloKMQjBggESBDQ5NDkYrhwg4iIonoKRAzD8gpEDOEJAAVgBagVCQVNJQ3IIT1dGV1pOQloSCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Thu, Aug 6 - Mon, Aug 10 CLE Cleveland FLO Florence $535 Roundtrip found 1 day ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CLE,to:FLO,departure:8/6/2026TANYT&leg2=from:FLO,to:CLE,departure:8/10/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:534.40&airProductToken=AQpoCjIIwYIBEgQxMjQ0GOIiIOKaASiIsZQDMPCxlAM4QkAAWAFqBUJBU0lDcghPV0ZXWk5CWgoyCMGCARIENjEwMRjimgEg5XIox7KUAzCSs5QDOEJAAVgBagVCQVNJQ3IIT1dGV1pOQloKaAoyCMGCARIENTk4NxjlciDimgEo2tuUAzCk3JQDOEJAAFgBagVCQVNJQ3IIT1dGV1pOQloKMgjBggESBDEyNDQY4poBIOIiKPPclAMw1d2UAzhCQAFYAWoFQkFTSUNyCE9XRldaTkJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Thu, Aug 6 - Mon, Aug 10 CLE Cleveland FLO Florence $540 Roundtrip found 1 day ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CLE,to:FLO,departure:8/6/2026TANYT&leg2=from:FLO,to:CLE,departure:8/10/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:539.70&airProductToken=AQqaAQoxCMGCARIEMTMxNRjiIiCuHCiFq5QDMOCrlAM4QkAAWAFqBUJBU0lDcghPV0ZXWk5CWgoxCMGCARIDNDExGK4cIOKaASivrJQDMKqtlAM4QkABWAFqBUJBU0lDcghPV0ZXWk5CWgoyCMGCARIENTk4NxjimgEg5XIoga6UAzDBrpQDOEJAAVgBagVCQVNJQ3IIT1dGV1pOQloKaAoyCMGCARIENTkyMBjlciDimgEoqteUAzD115QDOEJAAFgBagVCQVNJQ3IIT1dGV1pOQloKMgjBggESBDEyNjQY4poBIOIiKNLZlAMwr9qUAzhCQAFYAWoFQkFTSUNyCE9XRldaTkJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, Jun 17 - Mon, Jun 29 CLE Cleveland FLO Florence $546 Roundtrip found 10 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CLE,to:FLO,departure:6/17/2026TANYT&leg2=from:FLO,to:CLE,departure:6/29/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:545.01&airProductToken=AQqbAQoxCMGCARIEMTMxNRjiIiCuHCiY-I8DMPr4jwM4QkAAWAFqBUJBU0lDcghPV0ZXVU5CWgoyCMGCARIEMzIyMhiuHCDimgEoyvmPAzDN-o8DOEJAAVgBagVCQVNJQ3IIT1dGV1VOQloKMgjBggESBDYwNzcY4poBIOVyKMH7jwMwgvyPAzhCQAFYAWoFQkFTSUNyCE9XRldVTkJaCpsBCjIIwYIBEgQ2MDA0GOVyIOKaASjh_pADMKD_kAM4QkAAWAFqBUJBU0lDcghPV0ZXWk5CWAoyCMGCARIEMjg0MxjimgEgrhwogICRAzCKgZEDOEJAAVgBagVCQVNJQ3IIT1dGV1pOQlgKMQjBggESBDQ5MDkYrhwg4iIo9oORAzDYhJEDOEJAAVgBagVCQVNJQ3IITldBSVpOQloSCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, Jun 17 - Mon, Jun 29 CLE Cleveland FLO Florence $588 Roundtrip found 4 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CLE,to:FLO,departure:6/17/2026TANYT&leg2=from:FLO,to:CLE,departure:6/29/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:587.41&airProductToken=AQpmCjEIwYIBEgQxNjgxGOIiIOKaASjp_I8DMNf9jwM4T0AAWAFqBE1BSU5yCE9XRldVTk0xCjEIwYIBEgQ1ODkzGOKaASDlciiX_48DMNj_jwM4T0ABWAFqBE1BSU5yCE9XRldVTk0xCmYKMQjBggESBDYwMDQY5XIg4poBKOH-kAMwoP-QAzhPQABYAWoETUFJTnIIT1dGV1pOTTEKMQjBggESBDE2NzcY4poBIOIiKPGAkQMw1YGRAzhPQAFYAWoETUFJTnIIT1dGV1pOTTESCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) ## Frequently asked questions ### How much does a flight from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional) cost? ### What is the cheapest month to fly from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional)? ### Which airlines fly direct from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional)? ### What is the cheapest airline that flies from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional)? ### How do I find cheap flights from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional)? ### What is the best time to fly from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional)? ### What is the earliest flight from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional)? ### How long does it take to fly from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional)? ### Can you fly business or first class from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional)? ### How do I earn miles on a Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional) flight with Expedia? ### What airports do you fly into for Florence from Hopkins Intl. (CLE)? ### Is it cheaper to buy a plane ticket from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional) at the last minute? ### Is it cheaper to book a Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package? ### Can I cancel or change the date of my flight from Cleveland, OH (CLE-Hopkins Intl.) to Florence, SC (FLO-Florence Regional)? ## Travel information | Origin airport | Hopkins Intl. | | ------------------- | ----------------- | | Destination airport | Florence Regional | | Airlines serving | American Airlines | | Roundtrip price | $455 | | Distance | 511 mi | \*Flight schedules are subject to change. \*Available to One Key members. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Florence Hotels ](https://www.expedia.com/Florence-Hotels.d1221.Travel-Guide-Hotels) - [Hotels near Florence National Cemetery ](https://www.expedia.com/Florence-National-Cemetery-Hotels.0-l553248621532657341-0.Travel-Guide-Filter-Hotels) - 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