$354 Cheap Flights from Rochester (ROC) to Florence (FLO)

View $354 flight on Sat, Aug 15, 2026Opens in a new window

Popular airlines from Greater Rochester Intl. Airport (ROC) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Rochester to Florence (ROC-FLO)

Prices were available within the past 7 days and start at $354 for one-way flights and $433 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Aug 15 - Sat, Aug 22
ROC
Rochester
FLO
Florence
$433 Roundtrip, found 21 hours ago
$433
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Sat, Aug 15 from Rochester to Florence, returning Sat, Aug 22, priced at $433 found 21 hours ago
American Airlines
Wed, Feb 18 - Tue, Mar 3
ROC
Rochester
FLO
Florence
$466 Roundtrip, found 5 days ago
$466
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Feb 18 from Rochester to Florence, returning Tue, Mar 3, priced at $466 found 5 days ago
American Airlines
Wed, Feb 18 - Tue, Mar 3
ROC
Rochester
FLO
Florence
$472 Roundtrip, found 5 days ago
$472
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Feb 18 from Rochester to Florence, returning Tue, Mar 3, priced at $472 found 5 days ago
American Airlines
Mon, Mar 9 - Tue, Mar 17
ROC
Rochester
FLO
Florence
$472 Roundtrip, found 3 days ago
$472
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Mar 9 from Rochester to Florence, returning Tue, Mar 17, priced at $472 found 3 days ago
American Airlines
Tue, Aug 11 - Wed, Aug 26
ROC
Rochester
FLO
Florence
$487 Roundtrip, found 19 hours ago
$487
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Tue, Aug 11 from Rochester to Florence, returning Wed, Aug 26, priced at $487 found 19 hours ago
American Airlines
Mon, Mar 16 - Tue, Mar 24
ROC
Rochester
FLO
Florence
$495 Roundtrip, found 3 days ago
$495
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Mar 16 from Rochester to Florence, returning Tue, Mar 24, priced at $495 found 3 days ago
American Airlines
Sat, Aug 15 - Sat, Aug 22
ROC
Rochester
FLO
Florence
$496 Roundtrip, found 21 hours ago
$496
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Sat, Aug 15 from Rochester to Florence, returning Sat, Aug 22, priced at $496 found 21 hours ago
American Airlines
Fri, Mar 20 - Sun, Mar 22
ROC
Rochester
FLO
Florence
$501 Roundtrip, found 19 hours ago
$501
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Fri, Mar 20 from Rochester to Florence, returning Sun, Mar 22, priced at $501 found 19 hours ago
American Airlines
Sat, Aug 8 - Wed, Aug 26
ROC
Rochester
FLO
Florence
$502 Roundtrip, found 19 hours ago
$502
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Sat, Aug 8 from Rochester to Florence, returning Wed, Aug 26, priced at $502 found 19 hours ago
American Airlines
Wed, Aug 12 - Sat, Aug 29
ROC
Rochester
FLO
Florence
$508 Roundtrip, found 19 hours ago
$508
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Wed, Aug 12 from Rochester to Florence, returning Sat, Aug 29, priced at $508 found 19 hours ago
Flights from Rochester (ROC) to Florence (FLO)
Origin airport
Greater Rochester Intl.
Destination airport
Florence Regional
Airlines serving
American Airlines
Roundtrip price
$432
Distance
627 mi

Rochester to Florence Flights

The cheapest times to fly from Rochester to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Rochester to Florence are during the month of August. You can find some of the cheapest flights from Rochester to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Rochester to Florence

Sunday is one of the best days to book for cheap flights from Rochester to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Rochester to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Rochester to Florence in 2026. You can also book with separate airlines for your outbound and return journeys, from $354 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Rochester to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Rochester to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional) cost?
You can find cheap one-way flights from $354 and cheap return flights from $433 Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional) with Expedia. One-way flights typically cost between $382 and $562, and return flights often range between $412 and $852. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional)?
The cheapest month to fly from ROC to FLO is August when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional)?
Enter ROC to FLO and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional)?
American Airlines is one of the cheapest airlines offering connecting flights from Greater Rochester Intl. (ROC) to Florence Regional (FLO) with a layover in O'Hare Intl. (ORD), starting from around $412. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional)?
To find a cheap flight from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional)?
Sort flights by "Departure (earliest)" on Expedia to find the earliest flight from ROC to FLO. To compare more early flights, use the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional)?
For flights from Rochester, NY (ROC) to Florence, SC (FLO), the most popular departure times are in the early morning, from 6am to 9am. About 34% of passengers choose this time window. American Airlines is a major carrier offering flights during this period. Many travelers prefer this timing as it allows for a full day upon arrival.
How long does it take to fly from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional)?
Flights from ROC to FLO with one stop typically take around 4 hours, covering approximately 627 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional)?
Select the "Business class" and "First class" filters when looking for ROC to FLO flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional) flight with Expedia?
It's easy to earn miles on a Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Florence from Greater Rochester Intl. (ROC)?
When traveling from Greater Rochester Intl. (ROC) to Florence, you can fly into Peretola (FLR) and Florence Regional (FLO). Some flights may connect through major hubs like Washington Dulles Intl. (IAD), Liberty Intl. (EWR), O'Hare Intl. (ORD) before reaching Florence. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional) at the last minute?
Typically, booking a last minute flight from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package?
Securing a Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional)?
If you booked your Rochester, NY (ROC-Greater Rochester Intl.) to Florence, SC (FLO-Florence Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

*Flight schedules are subject to change.

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*Available to One Key members.