$251 Cheap Flights from Rochester (ROC) to Florence (FLO)

View $251 flight on Fri, May 1, 2026Opens in a new window

Popular airlines from Greater Rochester Intl. Airport (ROC) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Rochester to Florence (ROC-FLO)

Prices were available within the past 7 days and start at $251 for one-way flights and $467 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Apr 15 - Sun, Apr 19
ROC
Rochester
FLO
Florence
$467 Roundtrip, found 2 days ago
$467
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Apr 15 from Rochester to Florence, returning Sun, Apr 19, priced at $467 found 2 days ago
American Airlines
Wed, Jun 17 - Sun, Jun 21
ROC
Rochester
FLO
Florence
$467 Roundtrip, found 3 days ago
$467
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jun 17 from Rochester to Florence, returning Sun, Jun 21, priced at $467 found 3 days ago
American Airlines
Sun, Feb 22 - Wed, Mar 11
ROC
Rochester
FLO
Florence
$487 Roundtrip, found 2 days ago
$487
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sun, Feb 22 from Rochester to Florence, returning Wed, Mar 11, priced at $487 found 2 days ago
American Airlines
Thu, Jun 18 - Thu, Jun 25
ROC
Rochester
FLO
Florence
$501 Roundtrip, found 11 hours ago
$501
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Thu, Jun 18 from Rochester to Florence, returning Thu, Jun 25, priced at $501 found 11 hours ago
American Airlines
Fri, May 1 - Sun, May 10
ROC
Rochester
FLO
Florence
$501 Roundtrip, found 5 days ago
$501
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, May 1 from Rochester to Florence, returning Sun, May 10, priced at $501 found 5 days ago
American Airlines
Tue, Jul 28 - Wed, Aug 12
ROC
Rochester
FLO
Florence
$502 Roundtrip, found 2 days ago
$502
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Jul 28 from Rochester to Florence, returning Wed, Aug 12, priced at $502 found 2 days ago
American Airlines
Sat, Aug 1 - Tue, Aug 18
ROC
Rochester
FLO
Florence
$503 Roundtrip, found 2 days ago
$503
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Aug 1 from Rochester to Florence, returning Tue, Aug 18, priced at $503 found 2 days ago
American Airlines
Tue, Jun 16 - Tue, Jun 30
ROC
Rochester
FLO
Florence
$508 Roundtrip, found 2 days ago
$508
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Jun 16 from Rochester to Florence, returning Tue, Jun 30, priced at $508 found 2 days ago
American Airlines
Tue, Mar 24 - Sat, Apr 11
ROC
Rochester
FLO
Florence
$514 Roundtrip, found 2 days ago
$514
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Mar 24 from Rochester to Florence, returning Sat, Apr 11, priced at $514 found 2 days ago
American Airlines
Tue, Feb 10 - Sat, Feb 28
ROC
Rochester
FLO
Florence
$517 Roundtrip, found 2 days ago
$517
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Feb 10 from Rochester to Florence, returning Sat, Feb 28, priced at $517 found 2 days ago

Alternative airports near Florence

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Florence Regional FLO. Cheapest and Closest option available. Average driving time to city center is 5 minutes. Flights from $590
FLO
Florence Regional
CheapestClosest
Average driving time to city center5 min
Flights from $590
Flights from Rochester (ROC) to Florence (FLO)
Origin airport
Greater Rochester Intl.
Destination airport
Florence Regional
Airlines serving
American Airlines
Roundtrip price
$466
Distance
627 mi

Rochester to Florence Flights

The cheapest times to fly from Rochester to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Rochester to Florence are during the month of April. You can find some of the cheapest flights from Rochester to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Rochester to Florence

Sunday is one of the best days to book for cheap flights from Rochester to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Rochester to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Rochester to Florence in 2026. You can also book with separate airlines for your outbound and return journeys, from $251 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Rochester to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Rochester to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Greater Rochester Intl. Airport (ROC) to Florence Regional Airport (FLO) cost?
Grab a cheap one-way flight from $251 or cheap return flight from $467 from Greater Rochester Intl. Airport (ROC) to Florence Regional Airport (FLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Greater Rochester Intl. Airport (ROC) to Florence Regional Airport (FLO)?
Planning your trip for April may help you find better deals, as it's the cheapest month for flights between ROC and FLO. You'll typically find the lowest fares during the off-season.
What is the cheapest airline that flies from Greater Rochester Intl. Airport (ROC) to Florence Regional Airport (FLO)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest ROC to FLO flight.
How many flights per day from Greater Rochester Intl. Airport (ROC) to Florence Regional Airport (FLO)?
You'll have to book a flight with a layover when traveling from Greater Rochester Intl. Airport (ROC) to Florence Regional Airport (FLO). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from ROC to FLO?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can change based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Greater Rochester Intl. Airport (ROC) to Florence Regional Airport (FLO)?
To avoid potential delays on the Greater Rochester Intl. Airport (ROC) to Florence Regional Airport (FLO) route, aim to travel before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Greater Rochester Intl. Airport (ROC) to Florence Regional Airport (FLO) last-minute?
Booking your ticket from ROC to FLO just before your journey is usually more expensive. But if there's some wiggle room with your departure times and dates, you could bag a cheap last-minute fare.
Is it cheaper to book a ROC to FLO flight and hotel package?
You'll typically save money by securing a ROC to FLO flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. Once you've selected your ideal flights and accommodations, consider adding extras including activities, car rentals and tours.
Can I cancel or change the date of my flight from Greater Rochester Intl. Airport (ROC) to Florence Regional Airport (FLO)?
You can usually reschedule or cancel your ROC to FLO flight. However, if it's been more than 24 hours since booking, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more information on our Customer Service portal.

*Flight schedules are subject to change.

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*Available to One Key members.