$163 Cheap Flights from Chicago (ORD) to Florence (FLO)

View $163 flight on Sat, May 30, 2026Opens in a new window

Popular airlines from Chicago O'Hare Intl. Airport (ORD) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Chicago to Florence (ORD-FLO)

Prices were available within the past 7 days and start at $163 for one-way flights and $325 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Oct 10 - Sat, Oct 17
ORD
Chicago
FLO
Florence
$325 Roundtrip, found 1 day ago
$325
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Oct 10 from Chicago to Florence, returning Sat, Oct 17, priced at $325 found 1 day ago
American Airlines
Tue, Jun 2 - Tue, Jun 9
ORD
Chicago
FLO
Florence
$330 Roundtrip, found 7 hours ago
$330
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Jun 2 from Chicago to Florence, returning Tue, Jun 9, priced at $330 found 7 hours ago
American Airlines
Thu, Mar 26 - Tue, Apr 7
ORD
Chicago
FLO
Florence
$335 Roundtrip, found 2 days ago
$335
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Mar 26 from Chicago to Florence, returning Tue, Apr 7, priced at $335 found 2 days ago
American Airlines
Fri, Aug 7 - Sat, Aug 15
ORD
Chicago
FLO
Florence
$337 Roundtrip, found 4 days ago
$337
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 7 from Chicago to Florence, returning Sat, Aug 15, priced at $337 found 4 days ago
American Airlines
Mon, Mar 23 - Fri, Mar 27
ORD
Chicago
FLO
Florence
$347 Roundtrip, found 3 days ago
$347
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Mar 23 from Chicago to Florence, returning Fri, Mar 27, priced at $347 found 3 days ago
American Airlines
Sun, Apr 26 - Thu, Apr 30
ORD
Chicago
FLO
Florence
$359 Roundtrip, found 1 day ago
$359
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Apr 26 from Chicago to Florence, returning Thu, Apr 30, priced at $359 found 1 day ago
American Airlines
Sat, Oct 10 - Sat, Oct 17
ORD
Chicago
FLO
Florence
$360 Roundtrip, found 1 day ago
$360
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Oct 10 from Chicago to Florence, returning Sat, Oct 17, priced at $360 found 1 day ago
American Airlines
Sun, Apr 19 - Wed, Apr 22
ORD
Chicago
FLO
Florence
$369 Roundtrip, found 2 days ago
$369
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sun, Apr 19 from Chicago to Florence, returning Wed, Apr 22, priced at $369 found 2 days ago
American Airlines
Thu, Mar 19 - Mon, Mar 23
ORD
Chicago
FLO
Florence
$370 Roundtrip, found 1 day ago
$370
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Mar 19 from Chicago to Florence, returning Mon, Mar 23, priced at $370 found 1 day ago
American Airlines
Fri, May 1 - Sun, May 3
ORD
Chicago
FLO
Florence
$371 Roundtrip, found 2 days ago
$371
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, May 1 from Chicago to Florence, returning Sun, May 3, priced at $371 found 2 days ago

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Frequently asked questions

How much does a flight from O'Hare Intl. Airport (ORD) to Florence Regional Airport (FLO) cost?
Grab a cheap one-way flight from $163 or cheap return flight from $325 from O'Hare Intl. Airport (ORD) to Florence Regional Airport (FLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from O'Hare Intl. Airport (ORD) to Florence Regional Airport (FLO)?
The cheapest month to fly from ORD to FLO is October, when there's less demand. Off-peak season is generally when airlines offer better prices between these airports.
What is the cheapest airline that flies from O'Hare Intl. Airport (ORD) to Florence Regional Airport (FLO)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from ORD to FLO. Then, sort your results by "Price (lowest to highest)" to score a great deal.
How many flights per day from O'Hare Intl. Airport (ORD) to Florence Regional Airport (FLO)?
There aren't any daily nonstop flights available from O'Hare Intl. Airport (ORD) to Florence Regional Airport (FLO). But you can opt for flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be on your way before you know it.
What day of the week has the most flights from ORD to FLO?
Typically you'll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* But this can change based on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from O'Hare Intl. Airport (ORD) to Florence Regional Airport (FLO)?
To avoid potential delays on the O'Hare Intl. Airport (ORD) to Florence Regional Airport (FLO) route, travel before 3 PM. Later departures have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from O'Hare Intl. Airport (ORD) to Florence Regional Airport (FLO) last-minute?
Holding off until right before your break to book a flight from ORD to FLO generally means paying more. Although you may find some last-minute deals, they aren't always guaranteed. Be flexible with your itinerary to maximize your chances of getting a bargain.
Is it cheaper to book an ORD to FLO flight and hotel package?
Securing an ORD to FLO flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Choose from our wide range of hotels and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from O'Hare Intl. Airport (ORD) to Florence Regional Airport (FLO)?
Typically, it's possible to reschedule or cancel your ORD to FLO flight. However, for bookings made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Origin airport
O'Hare Intl.
Destination airport
Florence Regional
Airlines serving
American Airlines
Roundtrip price
$324
Distance
697 mi

Book with confidence

Chicago to Florence Flights

The cheapest times to fly from Chicago to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to Florence are during the month of October. You can find some of the cheapest flights from Chicago to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Chicago to Florence

Sunday is one of the best days to book for cheap flights from Chicago to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Chicago to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to Florence in 2026. You can also book with separate airlines for your outbound and return journeys, from $163 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Chicago to Florence Flights

*Flight schedules are subject to change.

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