$163 Cheap Flights from Chicago (ORD) to Florence (FLO)

View $163 flight on Thu, Apr 23, 2026Opens in a new window

Popular airlines from Chicago O'Hare Intl. Airport (ORD) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Chicago to Florence (ORD-FLO)

Prices were available within the past 7 days and start at $163 for one-way flights and $335 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Apr 22 - Sat, May 2
ORD
Chicago
FLO
Florence
$335 Roundtrip, found 14 hours ago
$335
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Apr 22 from Chicago to Florence, returning Sat, May 2, priced at $335 found 14 hours ago
American Airlines
Fri, Aug 7 - Sat, Aug 15
ORD
Chicago
FLO
Florence
$337 Roundtrip, found 1 day ago
$337
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Aug 7 from Chicago to Florence, returning Sat, Aug 15, priced at $337 found 1 day ago
American Airlines
Mon, Mar 23 - Fri, Mar 27
ORD
Chicago
FLO
Florence
$347 Roundtrip, found 7 hours ago
$347
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Mar 23 from Chicago to Florence, returning Fri, Mar 27, priced at $347 found 7 hours ago
American Airlines
Sat, Mar 14 - Sun, Mar 22
ORD
Chicago
FLO
Florence
$359 Roundtrip, found 4 days ago
$359
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Mar 14 from Chicago to Florence, returning Sun, Mar 22, priced at $359 found 4 days ago
American Airlines
Wed, Mar 11 - Wed, Mar 18
ORD
Chicago
FLO
Florence
$370 Roundtrip, found 3 days ago
$370
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Mar 11 from Chicago to Florence, returning Wed, Mar 18, priced at $370 found 3 days ago
American Airlines
Fri, Aug 7 - Sat, Aug 15
ORD
Chicago
FLO
Florence
$372 Roundtrip, found 1 day ago
$372
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Aug 7 from Chicago to Florence, returning Sat, Aug 15, priced at $372 found 1 day ago
American Airlines
Mon, Mar 23 - Fri, Mar 27
ORD
Chicago
FLO
Florence
$382 Roundtrip, found 7 hours ago
$382
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Mar 23 from Chicago to Florence, returning Fri, Mar 27, priced at $382 found 7 hours ago
American Airlines
Thu, Sep 17 - Sun, Sep 20
ORD
Chicago
FLO
Florence
$390 Roundtrip, found 2 days ago
$390
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Sep 17 from Chicago to Florence, returning Sun, Sep 20, priced at $390 found 2 days ago
American Airlines
Sat, Mar 14 - Sun, Mar 22
ORD
Chicago
FLO
Florence
$394 Roundtrip, found 4 days ago
$394
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Mar 14 from Chicago to Florence, returning Sun, Mar 22, priced at $394 found 4 days ago
American Airlines
Wed, Mar 18 - Thu, Mar 19
ORD
Chicago
FLO
Florence
$395 Roundtrip, found 1 day ago
$395
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Mar 18 from Chicago to Florence, returning Thu, Mar 19, priced at $395 found 1 day ago

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Alternative airports near Florence

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Florence Regional FLO. Cheapest and Closest option available. Average driving time to city center is 5 minutes. Flights from $461
FLO
Florence Regional
CheapestClosest
Average driving time to city center5 min
Flights from $461

Frequently asked questions

How much does a flight from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional) cost?
You can find cheap one-way flights from $163 and cheap return flights from $335 Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional) with Expedia. One-way flights typically cost between $197 and $622, and return flights often range between $417 and $1205. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional)?
The cheapest month to fly from ORD to FLO is April when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional)?
Enter ORD to FLO and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional)?
Contour Airlines is one of the cheapest airlines offering connecting flights from O'Hare Intl. (ORD) to Florence Regional (FLO) with a layover in Owensboro-Daviess County Regional (OWB), starting from around $523. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional)?
To find a cheap flight from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional)?
The earliest flight from O'Hare International Airport (ORD) to Florence Regional Airport (FLO) usually departs at around 5:00 AM, operated by American Airlines. This seasonal service is active in January, November, and December, allowing you to start your day early in Florence. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
How long does it take to fly from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional)?
Flying from ORD to FLO with a connection usually takes about 6 hours 30 minutes, traveling roughly 697 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional)?
Select the "Business class" and "First class" filters when looking for ORD to FLO flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional) flight with Expedia?
It's easy to earn miles on a Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Florence from O'Hare Intl. (ORD)?
From O'Hare Intl. (ORD), you can fly into Peretola (FLR) and Florence Regional (FLO) in Florence. Some flights may connect through major hubs like Pearson Intl. (YYZ), Pierre Elliott Trudeau Intl. (YUL), Logan Intl. (BOS) before reaching Florence. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional) at the last minute?
Typically, booking a last minute flight from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package?
Securing a Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional)?
If you booked your Chicago, IL (ORD-O'Hare Intl.) to Florence, SC (FLO-Florence Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
O'Hare Intl.
Destination airport
Florence Regional
Airlines serving
American Airlines
Roundtrip price
$334
Distance
697 mi

Book with confidence

Chicago to Florence Flights

The cheapest times to fly from Chicago to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to Florence are during the month of April. You can find some of the cheapest flights from Chicago to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Chicago to Florence

Sunday is one of the best days to book for cheap flights from Chicago to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Chicago to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to Florence in 2026. You can also book with separate airlines for your outbound and return journeys, from $163 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Chicago to Florence Flights

*Flight schedules are subject to change.

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