$382 Cheap Flights from Chihuahua (CUU) to Knoxville (TYS)

View $382 flight on Wed, Nov 5, 2025Opens in a new window

Popular airlines from Chihuahua, Chihuahua (CUU-General Roberto Fierro Villalobos Intl.) to McGhee Tyson Airport (TYS)

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Cheap Flights from Chihuahua to Knoxville (CUU-TYS)

Prices were available within the past 7 days and start at $382 for one-way flights and $702 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Dec 20 - Sun, Dec 28
CUU
Chihuahua
TYS
Knoxville
$702 Roundtrip, found 1 day ago
$702
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Dec 20 from Chihuahua to Knoxville, returning Sun, Dec 28, priced at $702 found 1 day ago
American Airlines
Wed, Dec 17 - Wed, Dec 31
CUU
Chihuahua
TYS
Knoxville
$715 Roundtrip, found 1 day ago
$715
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 17 from Chihuahua to Knoxville, returning Wed, Dec 31, priced at $715 found 1 day ago
American Airlines
Sat, Dec 20 - Sun, Dec 28
CUU
Chihuahua
TYS
Knoxville
$723 Roundtrip, found 1 day ago
$723
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Dec 20 from Chihuahua to Knoxville, returning Sun, Dec 28, priced at $723 found 1 day ago
American Airlines
Wed, Dec 17 - Tue, Dec 30
CUU
Chihuahua
TYS
Knoxville
$724 Roundtrip, found 1 day ago
$724
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 17 from Chihuahua to Knoxville, returning Tue, Dec 30, priced at $724 found 1 day ago
American Airlines
Wed, Dec 17 - Fri, Dec 26
CUU
Chihuahua
TYS
Knoxville
$757 Roundtrip, found 1 day ago
$757
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 17 from Chihuahua to Knoxville, returning Fri, Dec 26, priced at $757 found 1 day ago
American Airlines
Mon, Dec 22 - Wed, Dec 31
CUU
Chihuahua
TYS
Knoxville
$759 Roundtrip, found 1 day ago
$759
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Dec 22 from Chihuahua to Knoxville, returning Wed, Dec 31, priced at $759 found 1 day ago
American Airlines
Sun, Dec 21 - Wed, Dec 31
CUU
Chihuahua
TYS
Knoxville
$765 Roundtrip, found 1 day ago
$765
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Dec 21 from Chihuahua to Knoxville, returning Wed, Dec 31, priced at $765 found 1 day ago
American Airlines
Sat, Dec 20 - Sun, Dec 28
CUU
Chihuahua
TYS
Knoxville
$766 Roundtrip, found 1 day ago
$766
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Dec 20 from Chihuahua to Knoxville, returning Sun, Dec 28, priced at $766 found 1 day ago
American Airlines
Tue, Dec 23 - Tue, Dec 30
CUU
Chihuahua
TYS
Knoxville
$767 Roundtrip, found 1 day ago
$767
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Dec 23 from Chihuahua to Knoxville, returning Tue, Dec 30, priced at $767 found 1 day ago
Delta
Sat, Dec 20 - Sun, Dec 28
CUU
Chihuahua
TYS
Knoxville
$2,984 Roundtrip, found 1 day ago
$2,984
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Dec 20 from Chihuahua to Knoxville, returning Sun, Dec 28, priced at $2,984 found 1 day ago

Frequently asked questions

How much does a flight from General Roberto Fierro Villalobos Intl. Airport (CUU) to McGhee Tyson Airport (TYS) cost?
Snag a cheap one-way flight from $382 or cheap return flight from $702 from General Roberto Fierro Villalobos Intl. Airport (CUU) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from General Roberto Fierro Villalobos Intl. Airport (CUU) to McGhee Tyson Airport (TYS)?
Flying in December can help you save, as it's the cheapest month for flights between CUU and TYS. You'll typically find the lowest prices during off-peak months.
What is the cheapest airline that flies from General Roberto Fierro Villalobos Intl. Airport (CUU) to McGhee Tyson Airport (TYS)?
To find the cheapest airline that'll fly you from CUU to TYS, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from General Roberto Fierro Villalobos Intl. Airport (CUU) to McGhee Tyson Airport (TYS)?
Direct flights from General Roberto Fierro Villalobos Intl. Airport (CUU) to McGhee Tyson Airport (TYS) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from CUU to TYS?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from General Roberto Fierro Villalobos Intl. Airport (CUU) to McGhee Tyson Airport (TYS)?
To avoid potential delays on the General Roberto Fierro Villalobos Intl. Airport (CUU) to McGhee Tyson Airport (TYS) route, aim to travel before 3 PM. Departures after this hour are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from General Roberto Fierro Villalobos Intl. Airport (CUU) to McGhee Tyson Airport (TYS) last-minute?
Waiting until just before your trip to book a flight from CUU to TYS generally means paying more. While you may come across some last-minute offers, there's no guarantee. Be flexible with your itinerary to maximize your chances of scoring a bargain.
Is it cheaper to book a CUU to TYS flight and hotel package?
Securing a CUU to TYS flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Select from our wide range of hotels and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from General Roberto Fierro Villalobos Intl. Airport (CUU) to McGhee Tyson Airport (TYS)?
In most cases, you can cancel or modify your CUU to TYS flight. However, additional fees may apply, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline's fees and rules on flight changes, or if you want further details, visit our Customer Service portal.

Travel information

Origin airport
General Roberto Fierro Villalobos Intl.
Destination airport
McGhee Tyson
Roundtrip price
$702
Distance
1370 mi

Book with confidence

Chihuahua to Knoxville Flights

The cheapest times to fly from Chihuahua to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chihuahua to Knoxville are during the month of December. You can find some of the cheapest flights from Chihuahua to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Chihuahua to Knoxville

Sunday is one of the best days to book for cheap flights from Chihuahua to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Chihuahua to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chihuahua to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $382 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chihuahua to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chihuahua to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Chihuahua to Knoxville Flights

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*Available to One Key members.