$254 Cheap Flights from Detroit (DTW) to Florence (FLO)

View $254 flight on Wed, May 20, 2026Opens in a new window

Popular airlines from Detroit Metropolitan Wayne County Airport (DTW) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Detroit to Florence (DTW-FLO)

Prices were available within the past 7 days and start at $254 for one-way flights and $343 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Jul 1 - Mon, Jul 6
DTW
Detroit
FLO
Florence
$343 Roundtrip, found 3 days ago
$343
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 1 from Detroit to Florence, returning Mon, Jul 6, priced at $343 found 3 days ago
American Airlines
Sat, May 30 - Sun, May 31
DTW
Detroit
FLO
Florence
$348 Roundtrip, found 6 days ago
$348
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 30 from Detroit to Florence, returning Sun, May 31, priced at $348 found 6 days ago
American Airlines
Wed, Jul 1 - Sun, Jul 5
DTW
Detroit
FLO
Florence
$353 Roundtrip, found 4 days ago
$353
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Jul 1 from Detroit to Florence, returning Sun, Jul 5, priced at $353 found 4 days ago
American Airlines
Wed, Jul 1 - Mon, Jul 6
DTW
Detroit
FLO
Florence
$373 Roundtrip, found 3 days ago
$373
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 1 from Detroit to Florence, returning Mon, Jul 6, priced at $373 found 3 days ago
American Airlines
Fri, Jul 3 - Wed, Jul 8
DTW
Detroit
FLO
Florence
$378 Roundtrip, found 3 days ago
$378
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Jul 3 from Detroit to Florence, returning Wed, Jul 8, priced at $378 found 3 days ago
American Airlines
Wed, May 20 - Fri, May 29
DTW
Detroit
FLO
Florence
$384 Roundtrip, found 5 days ago
$384
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, May 20 from Detroit to Florence, returning Fri, May 29, priced at $384 found 5 days ago
American Airlines
Fri, May 22 - Sat, May 30
DTW
Detroit
FLO
Florence
$386 Roundtrip, found 5 days ago
$386
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, May 22 from Detroit to Florence, returning Sat, May 30, priced at $386 found 5 days ago
American Airlines
Wed, May 20 - Fri, May 29
DTW
Detroit
FLO
Florence
$389 Roundtrip, found 5 days ago
$389
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, May 20 from Detroit to Florence, returning Fri, May 29, priced at $389 found 5 days ago
American Airlines
Fri, May 22 - Sat, May 30
DTW
Detroit
FLO
Florence
$391 Roundtrip, found 5 days ago
$391
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, May 22 from Detroit to Florence, returning Sat, May 30, priced at $391 found 5 days ago
American Airlines
Wed, May 13 - Wed, May 20
DTW
Detroit
FLO
Florence
$395 Roundtrip, found 5 days ago
$395
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, May 13 from Detroit to Florence, returning Wed, May 20, priced at $395 found 5 days ago

Frequently asked questions

How much does a flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional) cost?
You can find cheap one-way flights and cheap return flights from $343 Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional) with Expedia. One-way flights generally range between $417 and $597, and roundtrip flights usually range from $388 to $947. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional)?
The cheapest month to fly from DTW to FLO is July when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional)?
Enter DTW to FLO and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional)?
American Airlines is one of the cheapest airlines offering connecting flights from Detroit, MI (DTW) to Florence, SC (FLO), with round-trip tickets starting from around $302.37 with a layover in O'Hare Intl. (ORD). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional)?
To find a cheap flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional)?
The earliest flight from Detroit Metropolitan Wayne County Airport (DTW) to Florence Regional Airport (FLO) typically departs at around 5:25 AM, operated by American Airlines. An early departure like this allows you to make the most of your day in Florence. This service operates seasonally in June. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional)?
The most popular departure times for flights from Detroit (DTW) to Florence (FLO) are in the late morning, from 9am to noon. About 27% of passengers prefer this time window. American Airlines offers flights during this window. This timing works well because it allows you to travel after a morning routine, making it convenient for many travelers.
How long does it take to fly from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional)?
Flights from DTW to FLO with one stop typically take around 4 hours, covering approximately 588 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional)?
Select the "Business class" and "First class" filters when looking for DTW to FLO flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional) flight with Expedia?
It's easy to earn miles on a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Florence from Detroit Metropolitan Wayne County (DTW)?
From Detroit Metropolitan Wayne County (DTW), you can fly into Florence Regional (FLO) and Peretola (FLR) in Florence. Some flights may connect through major hubs like O'Hare Intl. (ORD), Ronald Reagan Washington National (DCA), Dallas-Fort Worth Intl. (DFW) before reaching Florence. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional) at the last minute?
Typically, booking a last minute flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional) flight and hotel package?
Securing a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional)?
If you booked your Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Florence, SC (FLO-Florence Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Detroit Metropolitan Wayne County
Destination airport
Florence Regional
Roundtrip price
$342
Distance
588 mi

Book with confidence

Detroit to Florence Flights

The cheapest times to fly from Detroit to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Detroit to Florence are during the month of July. You can find some of the cheapest flights from Detroit to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Detroit to Florence

Sunday is one of the best days to book for cheap flights from Detroit to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Detroit to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Detroit to Florence in 2026. You can also book with separate airlines for your outbound and return journeys, from $254 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Detroit to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Detroit to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Detroit to Florence Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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