$249 Cheap Flights from Key West (EYW) to Panama City (ECP)

View $249 flight on Mon, Dec 1, 2025Opens in a new window

Popular airlines from Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP)

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Cheap Flights from Key West to Panama City (EYW-ECP)

Prices were available within the past 7 days and start at $249 for one-way flights and $307 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Mar 25 - Tue, Apr 7
EYW
Key West
ECP
Panama City
$307 Roundtrip, found 3 days ago
$307
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Mar 25 from Key West to Panama City, returning Tue, Apr 7, priced at $307 found 3 days ago
American Airlines
Tue, Dec 2 - Sat, Dec 6
EYW
Key West
ECP
Panama City
$317 Roundtrip, found 6 days ago
$317
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 2 from Key West to Panama City, returning Sat, Dec 6, priced at $317 found 6 days ago
Delta
Thu, Oct 23 - Wed, Oct 29
EYW
Key West
ECP
Panama City
$334 Roundtrip, found 3 days ago
$334
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 23 from Key West to Panama City, returning Wed, Oct 29, priced at $334 found 3 days ago
Delta
Thu, Oct 23 - Mon, Oct 27
EYW
Key West
ECP
Panama City
$339 Roundtrip, found 3 days ago
$339
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 23 from Key West to Panama City, returning Mon, Oct 27, priced at $339 found 3 days ago
American Airlines
Tue, Dec 2 - Sat, Dec 6
EYW
Key West
ECP
Panama City
$343 Roundtrip, found 6 days ago
$343
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 2 from Key West to Panama City, returning Sat, Dec 6, priced at $343 found 6 days ago
Delta
Wed, Mar 25 - Mon, Apr 6
EYW
Key West
ECP
Panama City
$353 Roundtrip, found 3 days ago
$353
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Mar 25 from Key West to Panama City, returning Mon, Apr 6, priced at $353 found 3 days ago
Delta
Tue, Dec 2 - Sat, Dec 6
EYW
Key West
ECP
Panama City
$357 Roundtrip, found 6 days ago
$357
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Dec 2 from Key West to Panama City, returning Sat, Dec 6, priced at $357 found 6 days ago
Delta
Tue, Oct 21 - Wed, Oct 29
EYW
Key West
ECP
Panama City
$359 Roundtrip, found 3 days ago
$359
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Oct 21 from Key West to Panama City, returning Wed, Oct 29, priced at $359 found 3 days ago
Delta
Tue, Oct 21 - Mon, Oct 27
EYW
Key West
ECP
Panama City
$364 Roundtrip, found 3 days ago
$364
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Oct 21 from Key West to Panama City, returning Mon, Oct 27, priced at $364 found 3 days ago
United
Fri, Apr 3 - Sun, Apr 5
EYW
Key West
ECP
Panama City
$4,213 Roundtrip, found 1 day ago
$4,213
Roundtrip
found 1 day ago
Select United flight, departing Fri, Apr 3 from Key West to Panama City, returning Sun, Apr 5, priced at $4,213 found 1 day ago

Find the cheapest month to fly from Key West (EYW) to Panama City (ECP)

September is typically the cheapest month to fly

From $296 - $774 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Northwest Florida Beaches Intl. ECP. Cheapest and Closest option available. Average driving time to city center is 35 minutes. Flights from $788
ECP
Northwest Florida Beaches Intl.
CheapestClosest
Average driving time to city center35 min
Flights from $788

Frequently asked questions

How much does a flight from Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP) cost?
Get a cheap one-way flight from $249 or cheap return flight from $307 from Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP)?
March is the least expensive month to fly from EYW to ECP. Traveling outside of peak seasons is often the key to finding a great deal.
What is the cheapest airline that flies from Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll take you from EYW to ECP. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP)?
Nonstop flights from Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from EYW to ECP?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP)?
To avoid potential delays on the Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP) route, aim to travel before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP) last-minute?
Last-minute fares from EYW to ECP are generally more expensive. To lock in the best prices, start searching for flights early. That said, if you can play around with your travel dates, you may land a cheap ticket right before your journey.
Is it cheaper to book an EYW to ECP flight and hotel package?
You'll typically save money by securing an EYW to ECP flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. After selecting your preferred accommodations and flights, consider other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Key West Intl. Airport (EYW) to Northwest Florida Beaches Intl. Airport (ECP)?
Typically, you can cancel or modify your EYW to ECP flight. However, additional charges may apply, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's fees and rules on flight changes, or if you want further information, go to our Customer Service portal.

Travel information

Origin airport
Key West Intl.
Destination airport
Northwest Florida Beaches Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$306
Distance
471 mi

Book with confidence

Key West to Panama City Flights

The cheapest times to fly from Key West to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Key West to Panama City are during the month of March. You can find some of the cheapest flights from Key West to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Key West to Panama City

Sunday is one of the best days to book for cheap flights from Key West to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Key West to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Key West to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $249 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Key West to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Key West to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Key West to Panama City Flights

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*Available to One Key members.