$141 Cheap Flights from Greenville (GSP) to St. Louis (STL)

View $141 flight on Wed, Dec 3, 2025Opens in a new window

Popular airlines from Greenville-Spartanburg Intl. Airport (GSP) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Greenville to St. Louis (GSP-STL)

Prices were available within the past 7 days and start at $141 for one-way flights and $281 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Dec 16 - Wed, Jan 7
GSP
Greenville
STL
St. Louis
$281 Roundtrip, found 1 day ago
$281
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Dec 16 from Greenville to St. Louis, returning Wed, Jan 7, priced at $281 found 1 day ago
American Airlines
Wed, Dec 3 - Sun, Dec 7
GSP
Greenville
STL
St. Louis
$285 Roundtrip, found 3 days ago
$285
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Dec 3 from Greenville to St. Louis, returning Sun, Dec 7, priced at $285 found 3 days ago
Delta
Sun, Jan 18 - Tue, Jan 27
GSP
Greenville
STL
St. Louis
$289 Roundtrip, found 1 day ago
$289
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Jan 18 from Greenville to St. Louis, returning Tue, Jan 27, priced at $289 found 1 day ago
American Airlines
Tue, Dec 2 - Wed, Dec 10
GSP
Greenville
STL
St. Louis
$293 Roundtrip, found 3 days ago
$293
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Dec 2 from Greenville to St. Louis, returning Wed, Dec 10, priced at $293 found 3 days ago
Southwest Airlines
Wed, Dec 3 - Sun, Dec 7
GSP
Greenville
STL
St. Louis
$294 Roundtrip, found 3 days ago
$294
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Wed, Dec 3 from Greenville to St. Louis, returning Sun, Dec 7, priced at $294 found 3 days ago
Delta
Mon, Nov 24 - Tue, Dec 2
GSP
Greenville
STL
St. Louis
$297 Roundtrip, just found
$297
Roundtrip
just found
Select Delta flight, departing Mon, Nov 24 from Greenville to St. Louis, returning Tue, Dec 2, priced at $297 just found
American Airlines
Wed, Dec 3 - Sun, Dec 7
GSP
Greenville
STL
St. Louis
$299 Roundtrip, found 3 days ago
$299
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Dec 3 from Greenville to St. Louis, returning Sun, Dec 7, priced at $299 found 3 days ago
Delta
Thu, Dec 18 - Wed, Jan 7
GSP
Greenville
STL
St. Louis
$300 Roundtrip, found 1 day ago
$300
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Dec 18 from Greenville to St. Louis, returning Wed, Jan 7, priced at $300 found 1 day ago
Southwest Airlines
Wed, Dec 3 - Sun, Dec 7
GSP
Greenville
STL
St. Louis
$304 Roundtrip, found 3 days ago
$304
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Wed, Dec 3 from Greenville to St. Louis, returning Sun, Dec 7, priced at $304 found 3 days ago
United
Thu, Dec 25 - Tue, Dec 30
GSP
Greenville
STL
St. Louis
$307 Roundtrip, found 4 days ago
$307
Roundtrip
found 4 days ago
Select United flight, departing Thu, Dec 25 from Greenville to St. Louis, returning Tue, Dec 30, priced at $307 found 4 days ago

Find the cheapest month to fly from Greenville (GSP) to St. Louis (STL)

August is typically the cheapest month to fly

From $178 - $466 per traveler.

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $372
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $372

Frequently asked questions

How much does a flight from Greenville-Spartanburg Intl. Airport (GSP) to Lambert-St. Louis Intl. Airport (STL) cost?
Grab a cheap one-way flight from $141 or cheap return flight from $281 from Greenville-Spartanburg Intl. Airport (GSP) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Greenville-Spartanburg Intl. Airport (GSP) to Lambert-St. Louis Intl. Airport (STL)?
December is the cheapest month to fly from GSP to STL. Traveling during an off-peak travel window is often the key to finding better deals on flights.
What is the cheapest airline that flies from Greenville-Spartanburg Intl. Airport (GSP) to Lambert-St. Louis Intl. Airport (STL)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll fly you from GSP to STL. Then, sort your results by "Price (lowest to highest)" to snag a great deal.
How many flights per day from Greenville-Spartanburg Intl. Airport (GSP) to Lambert-St. Louis Intl. Airport (STL)?
Direct flights from Greenville-Spartanburg Intl. Airport (GSP) to Lambert-St. Louis Intl. Airport (STL) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from GSP to STL?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Greenville-Spartanburg Intl. Airport (GSP) to Lambert-St. Louis Intl. Airport (STL)?
To avoid potential delays on the Greenville-Spartanburg Intl. Airport (GSP) to Lambert-St. Louis Intl. Airport (STL) route, travel before 3 PM. Departures after this hour are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Greenville-Spartanburg Intl. Airport (GSP) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Booking your ticket from GSP to STL right before your journey is typically more expensive. However, if there's some wiggle room with your travel dates and times, you could land a cheap last-minute fare.
Is it cheaper to book a GSP to STL flight and hotel package?
Compared with arranging flights and hotels separately, booking a GSP to STL flight and hotel package with Expedia could result in significant savings. What's more, having everything in one convenient place will take the stress out of travel planning. Simply pick your flights and choose from our extensive range of hotels, then personalize your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Greenville-Spartanburg Intl. Airport (GSP) to Lambert-St. Louis Intl. Airport (STL)?
It's usually possible to reschedule or cancel your GSP to STL flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Origin airport
Greenville-Spartanburg Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$280
Distance
523 mi

Book with confidence

Greenville to St. Louis Flights

The cheapest times to fly from Greenville to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Greenville to St. Louis are during the month of December. You can find some of the cheapest flights from Greenville to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Greenville to St. Louis

Sunday is one of the best days to book for cheap flights from Greenville to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Greenville to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Greenville to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $141 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Greenville to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Greenville to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Greenville to St. Louis Flights

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*Available to One Key members.