$210 Cheap Flights from Laredo (LRD) to Knoxville (TYS)

View $210 flight on Fri, Dec 12, 2025Opens in a new window

Popular airlines from Laredo, TX (LRD-Laredo Intl.) to McGhee Tyson Airport (TYS)

Cheap Flights from Laredo to Knoxville (LRD-TYS)

Prices were available within the past 7 days and start at $210 for one-way flights and $259 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Nov 7 - Mon, Nov 10
LRD
Laredo
TYS
Knoxville
$259 Roundtrip, found 6 days ago
$259
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Nov 7 from Laredo to Knoxville, returning Mon, Nov 10, priced at $259 found 6 days ago
American Airlines
Wed, Nov 5 - Sat, Nov 8
LRD
Laredo
TYS
Knoxville
$306 Roundtrip, found 6 days ago
$306
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Nov 5 from Laredo to Knoxville, returning Sat, Nov 8, priced at $306 found 6 days ago
American Airlines
Wed, Nov 5 - Sat, Nov 8
LRD
Laredo
TYS
Knoxville
$333 Roundtrip, found 6 days ago
$333
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Nov 5 from Laredo to Knoxville, returning Sat, Nov 8, priced at $333 found 6 days ago
United
Tue, Nov 18 - Fri, Nov 28
LRD
Laredo
TYS
Knoxville
$339 Roundtrip, found 2 days ago
$339
Roundtrip
found 2 days ago
Select United flight, departing Tue, Nov 18 from Laredo to Knoxville, returning Fri, Nov 28, priced at $339 found 2 days ago
American Airlines
Tue, Nov 18 - Sat, Dec 6
LRD
Laredo
TYS
Knoxville
$344 Roundtrip, found 2 days ago
$344
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Nov 18 from Laredo to Knoxville, returning Sat, Dec 6, priced at $344 found 2 days ago
American Airlines
Thu, Nov 20 - Mon, Nov 24
LRD
Laredo
TYS
Knoxville
$369 Roundtrip, found 2 days ago
$369
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Nov 20 from Laredo to Knoxville, returning Mon, Nov 24, priced at $369 found 2 days ago
United
Mon, Nov 17 - Fri, Nov 28
LRD
Laredo
TYS
Knoxville
$379 Roundtrip, found 2 days ago
$379
Roundtrip
found 2 days ago
Select United flight, departing Mon, Nov 17 from Laredo to Knoxville, returning Fri, Nov 28, priced at $379 found 2 days ago
American Airlines
Wed, Nov 5 - Sun, Nov 9
LRD
Laredo
TYS
Knoxville
$385 Roundtrip, found 6 days ago
$385
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Nov 5 from Laredo to Knoxville, returning Sun, Nov 9, priced at $385 found 6 days ago
American Airlines
Tue, Nov 18 - Wed, Dec 10
LRD
Laredo
TYS
Knoxville
$386 Roundtrip, found 2 days ago
$386
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Nov 18 from Laredo to Knoxville, returning Wed, Dec 10, priced at $386 found 2 days ago
American Airlines
Fri, Dec 12 - Sun, Dec 14
LRD
Laredo
TYS
Knoxville
$389 Roundtrip, found 9 hours ago
$389
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Fri, Dec 12 from Laredo to Knoxville, returning Sun, Dec 14, priced at $389 found 9 hours ago

Frequently asked questions

How much does a flight from Laredo Intl. Airport (LRD) to McGhee Tyson Airport (TYS) cost?
Lock in a cheap one-way flight from $210 or cheap return flight from $259 from Laredo Intl. Airport (LRD) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Laredo Intl. Airport (LRD) to McGhee Tyson Airport (TYS)?
November is the cheapest month to fly from LRD to TYS. Traveling during quieter months is often the key to scoring lower fares.
What is the cheapest airline that flies from Laredo Intl. Airport (LRD) to McGhee Tyson Airport (TYS)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest LRD to TYS flight.
How many flights per day from Laredo Intl. Airport (LRD) to McGhee Tyson Airport (TYS)?
There aren't any daily direct flights departing from Laredo Intl. Airport (LRD) to McGhee Tyson Airport (TYS). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from LRD to TYS?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can vary based on various factors, including the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Laredo Intl. Airport (LRD) to McGhee Tyson Airport (TYS)?
To avoid possible delays on the Laredo Intl. Airport (LRD) to McGhee Tyson Airport (TYS) route, aim to fly before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Laredo Intl. Airport (LRD) to McGhee Tyson Airport (TYS) last-minute?
Booking your flight from LRD to TYS just before your getaway is usually more expensive. But if you're flexible with your schedule, you could bag a cheap last-minute fare.
Is it cheaper to book a LRD to TYS flight and hotel package?
Compared with arranging hotels and flights separately, booking a LRD to TYS flight and hotel package with Expedia could result in significant savings. Better still, having everything in one convenient place will take the stress out of travel planning. Just pick your flights and select from our extensive range of hotels, then customize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Laredo Intl. Airport (LRD) to McGhee Tyson Airport (TYS)?
If you booked your LRD to TYS flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you'd like more information.

Travel information

Travel information

Origin airport
Laredo Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, United
Roundtrip price
$258
Distance
1071 mi

Book with confidence

Book with confidence

Laredo to Knoxville Flights

The cheapest times to fly from Laredo to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Laredo to Knoxville are during the month of November. You can find some of the cheapest flights from Laredo to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Laredo to Knoxville

Sunday is one of the best days to book for cheap flights from Laredo to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Laredo to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Laredo to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $210 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Laredo to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Laredo to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Laredo to Knoxville Flights

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*Available to One Key members.