$131 Cheap Flights from McAllen (MFE) to Knoxville (TYS)

View $131 flight on Wed, Nov 5, 2025Opens in a new window

Popular airlines from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS)

Cheap Flights from McAllen to Knoxville (MFE-TYS)

Prices were available within the past 7 days and start at $131 for one-way flights and $259 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Dec 6 - Wed, Dec 10
MFE
McAllen
TYS
Knoxville
$259 Roundtrip, found 2 days ago
$259
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Dec 6 from McAllen to Knoxville, returning Wed, Dec 10, priced at $259 found 2 days ago
Delta
Wed, Nov 5 - Tue, Nov 18
MFE
McAllen
TYS
Knoxville
$261 Roundtrip, just found
$261
Roundtrip
just found
Select Delta flight, departing Wed, Nov 5 from McAllen to Knoxville, returning Tue, Nov 18, priced at $261 just found
United
Mon, Jan 26 - Sun, Feb 1
MFE
McAllen
TYS
Knoxville
$264 Roundtrip, found 5 days ago
$264
Roundtrip
found 5 days ago
Select United flight, departing Mon, Jan 26 from McAllen to Knoxville, returning Sun, Feb 1, priced at $264 found 5 days ago
Delta
Tue, Nov 4 - Thu, Nov 20
MFE
McAllen
TYS
Knoxville
$265 Roundtrip, found 2 days ago
$265
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Nov 4 from McAllen to Knoxville, returning Thu, Nov 20, priced at $265 found 2 days ago
Delta
Mon, Jan 12 - Thu, Jan 29
MFE
McAllen
TYS
Knoxville
$269 Roundtrip, found 3 days ago
$269
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Jan 12 from McAllen to Knoxville, returning Thu, Jan 29, priced at $269 found 3 days ago
American Airlines
Sat, Dec 6 - Wed, Dec 10
MFE
McAllen
TYS
Knoxville
$270 Roundtrip, found 2 days ago
$270
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Dec 6 from McAllen to Knoxville, returning Wed, Dec 10, priced at $270 found 2 days ago
American Airlines
Sat, Oct 25 - Tue, Oct 28
MFE
McAllen
TYS
Knoxville
$274 Roundtrip, found 4 days ago
$274
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Oct 25 from McAllen to Knoxville, returning Tue, Oct 28, priced at $274 found 4 days ago
Delta
Sat, Feb 14 - Fri, Feb 27
MFE
McAllen
TYS
Knoxville
$274 Roundtrip, found 3 days ago
$274
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, Feb 14 from McAllen to Knoxville, returning Fri, Feb 27, priced at $274 found 3 days ago
Delta
Wed, Nov 5 - Thu, Nov 20
MFE
McAllen
TYS
Knoxville
$275 Roundtrip, just found
$275
Roundtrip
just found
Select Delta flight, departing Wed, Nov 5 from McAllen to Knoxville, returning Thu, Nov 20, priced at $275 just found
Delta
Tue, Apr 21 - Sat, May 9
MFE
McAllen
TYS
Knoxville
$281 Roundtrip, found 3 days ago
$281
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Apr 21 from McAllen to Knoxville, returning Sat, May 9, priced at $281 found 3 days ago

Find the cheapest month to fly from McAllen (MFE) to Knoxville (TYS)

April is typically the cheapest month to fly

From $207 - $463 per traveler.

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $289
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $289

Frequently asked questions

How much does a flight from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS) cost?
Grab a cheap one-way flight from $131 or cheap return flight from $259 from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS)?
Traveling in December may help you find better deals, as it's the cheapest month for flights between MFE and TYS. You'll typically find the lowest prices during the off-season.
What is the cheapest airline that flies from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll take you from MFE to TYS. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS)?
You'll need to take a flight with a layover when traveling from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from MFE to TYS?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change depending on various factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS)?
Book a flight from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS) that takes off before 3 PM to reduce the likelihood of delays. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS) last-minute?
Waiting until just before your trip to book your flight from MFE to TYS often results in higher prices. Although you may find some last-minute deals, they're not always guaranteed. Be flexible with your itinerary to maximize your chances of getting a bargain.
Is it cheaper to book a MFE to TYS flight and hotel package?
Opting for a MFE to TYS flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Select from our wide range of accommodations and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Miller Intl. Airport (MFE) to McGhee Tyson Airport (TYS)?
In most instances, you're able to cancel or reschedule your MFE to TYS flight. However, additional charges may apply, especially if you made your booking over 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you'd like more information, go to our Customer Service portal.

Travel information

Travel information

Origin airport
Miller Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, United
Roundtrip price
$258
Distance
1072 mi

Book with confidence

Book with confidence

McAllen to Knoxville Flights

The cheapest times to fly from McAllen to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from McAllen to Knoxville are during the month of December. You can find some of the cheapest flights from McAllen to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from McAllen to Knoxville

Sunday is one of the best days to book for cheap flights from McAllen to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from McAllen to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from McAllen to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $131 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap McAllen to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your McAllen to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

McAllen to Knoxville Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.