$135 Cheap Flights from Portland (PDX) to Knoxville (TYS)

View $135 flight on Sat, Dec 13, 2025Opens in a new window

Popular airlines from Portland International Airport (PDX) to McGhee Tyson Airport (TYS)

Cheap Flights from Portland to Knoxville (PDX-TYS)

Prices were available within the past 7 days and start at $135 for one-way flights and $269 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Jan 28 - Wed, Feb 11
PDX
Portland
TYS
Knoxville
$269 Roundtrip, found 6 hours ago
$269
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Jan 28 from Portland to Knoxville, returning Wed, Feb 11, priced at $269 found 6 hours ago
Delta
Wed, Jan 14 - Sat, Jan 24
PDX
Portland
TYS
Knoxville
$269 Roundtrip, found 12 hours ago
$269
Roundtrip
found 12 hours ago
Select Delta flight, departing Wed, Jan 14 from Portland to Knoxville, returning Sat, Jan 24, priced at $269 found 12 hours ago
United
Wed, Jan 14 - Sat, Jan 24
PDX
Portland
TYS
Knoxville
$269 Roundtrip, found 12 hours ago
$269
Roundtrip
found 12 hours ago
Select United flight, departing Wed, Jan 14 from Portland to Knoxville, returning Sat, Jan 24, priced at $269 found 12 hours ago
Delta
Wed, Jan 28 - Wed, Feb 11
PDX
Portland
TYS
Knoxville
$271 Roundtrip, found 6 hours ago
$271
Roundtrip
found 6 hours ago
Select Delta flight, departing Wed, Jan 28 from Portland to Knoxville, returning Wed, Feb 11, priced at $271 found 6 hours ago
United
Sat, Nov 8 - Sat, Nov 15
PDX
Portland
TYS
Knoxville
$271 Roundtrip, found 15 hours ago
$271
Roundtrip
found 15 hours ago
Select United flight, departing Sat, Nov 8 from Portland to Knoxville, returning Sat, Nov 15, priced at $271 found 15 hours ago
United
Tue, Nov 4 - Sat, Nov 8
PDX
Portland
TYS
Knoxville
$273 Roundtrip, found 1 day ago
$273
Roundtrip
found 1 day ago
Select United flight, departing Tue, Nov 4 from Portland to Knoxville, returning Sat, Nov 8, priced at $273 found 1 day ago
Delta
Wed, Jan 28 - Wed, Feb 11
PDX
Portland
TYS
Knoxville
$274 Roundtrip, found 6 hours ago
$274
Roundtrip
found 6 hours ago
Select Delta flight, departing Wed, Jan 28 from Portland to Knoxville, returning Wed, Feb 11, priced at $274 found 6 hours ago
Delta
Wed, Dec 3 - Wed, Dec 10
PDX
Portland
TYS
Knoxville
$275 Roundtrip, found 19 hours ago
$275
Roundtrip
found 19 hours ago
Select Delta flight, departing Wed, Dec 3 from Portland to Knoxville, returning Wed, Dec 10, priced at $275 found 19 hours ago
Alaska Airlines
Wed, Jan 28 - Wed, Feb 11
PDX
Portland
TYS
Knoxville
$429 Roundtrip, found 6 hours ago
$429
Roundtrip
found 6 hours ago
Select Alaska Airlines flight, departing Wed, Jan 28 from Portland to Knoxville, returning Wed, Feb 11, priced at $429 found 6 hours ago
Southwest Airlines
Tue, Jun 16 - Tue, Jun 23
PDX
Portland
TYS
Knoxville
$447 Roundtrip, found 1 day ago
$447
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Tue, Jun 16 from Portland to Knoxville, returning Tue, Jun 23, priced at $447 found 1 day ago

Find the cheapest month to fly from Portland (PDX) to Knoxville (TYS)

November is typically the cheapest month to fly

From $198 - $851 per traveler.

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $800
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $800

Frequently asked questions

How much does a flight from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS) cost?
Secure a cheap one-way flight from $135 or cheap return flight from $269 from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS)?
The cheapest month to fly from PDX to TYS is January, when demand is low. Off-peak season is usually when better flight deals are available between these airports.
What is the cheapest airline that flies from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS)?
Use the filter tool on Expedia to compare different airlines and find the cheapest carrier that'll take you from PDX to TYS. Then, sort your results by "Price (lowest to highest)" to score a good deal.
How many flights per day from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS)?
You'll have to book a flight with a layover if you're traveling from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from PDX to TYS?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* But this can change depending on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS)?
Book a flight from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS) last-minute?
Booking your flight from PDX to TYS just before your getaway is generally more expensive. However, if there's some wiggle room with your departure times and dates, you could score a cheap last-minute fare.
Is it cheaper to book a PDX to TYS flight and hotel package?
Securing a PDX to TYS flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Pick from our impressive range of accommodations and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS)?
You can usually reschedule or cancel your PDX to TYS flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Portland Intl.
Destination airport
McGhee Tyson
Airlines serving
Alaska Airlines, American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$268
Distance
2108 mi

Book with confidence

Portland to Knoxville Flights

The cheapest times to fly from Portland to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Portland to Knoxville are during the month of January. You can find some of the cheapest flights from Portland to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Portland to Knoxville

Sunday is one of the best days to book for cheap flights from Portland to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Portland to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Portland to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $135 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Portland to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Portland to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Portland to Knoxville Flights

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*Available to One Key members.