$588 Cheap Flights from Reggio di Calabria (REG) to Knoxville (TYS)

View $588 flight on Sun, Feb 15, 2026Opens in a new window

Popular airlines from Strait of Messina Airport (REG) to McGhee Tyson Airport (TYS)

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Cheap Flights from Reggio di Calabria to Knoxville (REG-TYS)

Prices were available within the past 7 days and start at $588 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Flights from Reggio di Calabria (REG) to Knoxville (TYS)
Origin airport
Strait of Messina
Destination airport
McGhee Tyson
Distance
5202 mi

Reggio di Calabria to Knoxville Flights

The cheapest times to fly from Reggio di Calabria to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Reggio di Calabria to Knoxville are during the month of . You can find some of the cheapest flights from Reggio di Calabria to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Reggio di Calabria to Knoxville

Sunday is one of the best days to book for cheap flights from Reggio di Calabria to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Reggio di Calabria to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Reggio di Calabria to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $588 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Reggio di Calabria to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Reggio di Calabria to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Strait of Messina Airport (REG) to McGhee Tyson Airport (TYS) cost?
Lock in a cheap one-way flight from $588 or cheap return flight from Strait of Messina Airport (REG) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Strait of Messina Airport (REG) to McGhee Tyson Airport (TYS)?
The cheapest month to fly from REG to TYS is , when there's less demand. Off-peak months are typically when you'll find lower airfares between these airports.
What is the cheapest airline that flies from Strait of Messina Airport (REG) to McGhee Tyson Airport (TYS)?
To find the cheapest airline that'll fly you from REG to TYS, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Strait of Messina Airport (REG) to McGhee Tyson Airport (TYS)?
There are no daily nonstop flights departing from Strait of Messina Airport (REG) to McGhee Tyson Airport (TYS). But you can choose flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds in no time at all.
What day of the week has the most flights from REG to TYS?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can vary based on a number of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Strait of Messina Airport (REG) to McGhee Tyson Airport (TYS)?
To touch down at McGhee Tyson Airport (TYS) on time, choose a flight that leaves Strait of Messina Airport (REG) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Strait of Messina Airport (REG) to McGhee Tyson Airport (TYS) last-minute?
Booking your flight from REG to TYS right before your trip is typically more expensive. But if you're flexible with your departure dates and times, you could snag a cheap last-minute fare.
Is it cheaper to book a REG to TYS flight and hotel package?
You'll typically save money by booking a REG to TYS flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. Once you've selected your preferred accommodations and flights, consider other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Strait of Messina Airport (REG) to McGhee Tyson Airport (TYS)?
If you booked your REG to TYS flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

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*Available to One Key members.