$252 Cheap Flights from Syracuse (SYR) to Florence (FLO)

View $252 flight on Tue, Jun 2, 2026Opens in a new window

Popular airlines from Hancock Intl. Airport (SYR) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Syracuse to Florence (SYR-FLO)

Prices were available within the past 7 days and start at $252 for one-way flights and $473 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Jul 1 - Sat, Jul 11
SYR
Syracuse
FLO
Florence
$473 Roundtrip, found 18 hours ago
$473
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Jul 1 from Syracuse to Florence, returning Sat, Jul 11, priced at $473 found 18 hours ago
American Airlines
Wed, Jul 1 - Sat, Jul 11
SYR
Syracuse
FLO
Florence
$478 Roundtrip, found 18 hours ago
$478
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Jul 1 from Syracuse to Florence, returning Sat, Jul 11, priced at $478 found 18 hours ago
American Airlines
Sun, May 24 - Sun, May 31
SYR
Syracuse
FLO
Florence
$507 Roundtrip, found 16 hours ago
$507
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Sun, May 24 from Syracuse to Florence, returning Sun, May 31, priced at $507 found 16 hours ago
American Airlines
Sun, May 31 - Wed, Jun 3
SYR
Syracuse
FLO
Florence
$522 Roundtrip, found 5 days ago
$522
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sun, May 31 from Syracuse to Florence, returning Wed, Jun 3, priced at $522 found 5 days ago
American Airlines
Wed, May 20 - Thu, May 21
SYR
Syracuse
FLO
Florence
$527 Roundtrip, found 5 days ago
$527
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, May 20 from Syracuse to Florence, returning Thu, May 21, priced at $527 found 5 days ago
American Airlines
Tue, May 5 - Tue, May 12
SYR
Syracuse
FLO
Florence
$529 Roundtrip, found 3 days ago
$529
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, May 5 from Syracuse to Florence, returning Tue, May 12, priced at $529 found 3 days ago
American Airlines
Sat, May 2 - Sat, May 9
SYR
Syracuse
FLO
Florence
$534 Roundtrip, found 5 days ago
$534
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, May 2 from Syracuse to Florence, returning Sat, May 9, priced at $534 found 5 days ago
American Airlines
Tue, Jul 14 - Tue, Sep 29
SYR
Syracuse
FLO
Florence
$539 Roundtrip, found 3 days ago
$539
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jul 14 from Syracuse to Florence, returning Tue, Sep 29, priced at $539 found 3 days ago
American Airlines
Fri, May 22 - Tue, May 26
SYR
Syracuse
FLO
Florence
$540 Roundtrip, found 3 days ago
$540
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, May 22 from Syracuse to Florence, returning Tue, May 26, priced at $540 found 3 days ago
American Airlines
Wed, Jul 1 - Sat, Jul 11
SYR
Syracuse
FLO
Florence
$563 Roundtrip, found 18 hours ago
$563
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Jul 1 from Syracuse to Florence, returning Sat, Jul 11, priced at $563 found 18 hours ago

Frequently asked questions

How much does a flight from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) cost?
You can find cheap one-way flights from $252 and cheap return flights from $473 Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) with Expedia. One-way flights typically cost between $256 and $557, and return flights often range between $468 and $1163. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
The cheapest month to fly from SYR to FLO is July when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
Enter SYR to FLO and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
American Airlines is one of the cheapest airlines offering connecting flights from Syracuse (SYR) to Florence (FLO) with a layover in Philadelphia Intl. (PHL), starting from around $468. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
To find a cheap flight from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
The earliest flight from Hancock Intl. (SYR) to Florence Regional (FLO) generally departs at around 5:10 AM, operated by American Airlines. This seasonal service is available in June, giving you an early start to explore Florence. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
The most popular departure times for flights from Hancock Intl. (SYR) to Florence Regional (FLO) are from 6am to 9am. About 44% of passengers prefer this time window. Many major carriers, including American Airlines, offer flights during this window. This timing works well because it allows you to travel early and arrive in Florence with plenty of time to explore.
How long does it take to fly from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
A flight from SYR to FLO with a layover takes around 4 hours 20 minutes, with the route covering approximately 646 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
Select the "Business class" and "First class" filters when looking for SYR to FLO flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) flight with Expedia?
It's easy to earn miles on a Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Florence from Hancock Intl. (SYR)?
From Hancock Intl. (SYR), you can fly into Florence Regional (FLO) and Peretola (FLR) in Florence. Some flights may connect through major hubs like Philadelphia Intl. (PHL), Ronald Reagan Washington National (DCA), O'Hare Intl. (ORD) before reaching Florence. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) at the last minute?
Typically, booking a last minute flight from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package?
Securing a Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
If you booked your Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Hancock Intl.
Destination airport
Florence Regional
Roundtrip price
$472
Distance
646 mi

*Flight schedules are subject to change.

*Available to One Key members.

 

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