$328 Cheap Flights from Syracuse (SYR) to Florence (FLO)

View $328 flight on Thu, Apr 16, 2026Opens in a new window

Popular airlines from Hancock Intl. Airport (SYR) to Florence, SC (FLO-Florence Regional)

Cheap Flights from Syracuse to Florence (SYR-FLO)

Prices were available within the past 7 days and start at $328 for one-way flights and $546 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, May 14 - Sun, May 17
SYR
Syracuse
FLO
Florence
$546 Roundtrip, found 3 days ago
$546
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, May 14 from Syracuse to Florence, returning Sun, May 17, priced at $546 found 3 days ago
American Airlines
Thu, Jun 11 - Sun, Jun 14
SYR
Syracuse
FLO
Florence
$561 Roundtrip, found 3 days ago
$561
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Jun 11 from Syracuse to Florence, returning Sun, Jun 14, priced at $561 found 3 days ago
American Airlines
Thu, Apr 16 - Thu, Apr 23
SYR
Syracuse
FLO
Florence
$598 Roundtrip, found 1 day ago
$598
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Apr 16 from Syracuse to Florence, returning Thu, Apr 23, priced at $598 found 1 day ago
American Airlines
Thu, May 14 - Sun, May 17
SYR
Syracuse
FLO
Florence
$605 Roundtrip, found 3 days ago
$605
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, May 14 from Syracuse to Florence, returning Sun, May 17, priced at $605 found 3 days ago
American Airlines
Mon, Mar 23 - Wed, Apr 1
SYR
Syracuse
FLO
Florence
$619 Roundtrip, found 9 hours ago
$619
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Mon, Mar 23 from Syracuse to Florence, returning Wed, Apr 1, priced at $619 found 9 hours ago
American Airlines
Mon, Apr 13 - Mon, Apr 20
SYR
Syracuse
FLO
Florence
$623 Roundtrip, found 1 day ago
$623
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Apr 13 from Syracuse to Florence, returning Mon, Apr 20, priced at $623 found 1 day ago
American Airlines
Thu, May 14 - Sun, May 17
SYR
Syracuse
FLO
Florence
$626 Roundtrip, found 3 days ago
$626
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, May 14 from Syracuse to Florence, returning Sun, May 17, priced at $626 found 3 days ago
American Airlines
Thu, Apr 16 - Thu, Apr 23
SYR
Syracuse
FLO
Florence
$630 Roundtrip, found 1 day ago
$630
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Apr 16 from Syracuse to Florence, returning Thu, Apr 23, priced at $630 found 1 day ago
American Airlines
Thu, Apr 16 - Thu, Apr 23
SYR
Syracuse
FLO
Florence
$635 Roundtrip, found 1 day ago
$635
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Apr 16 from Syracuse to Florence, returning Thu, Apr 23, priced at $635 found 1 day ago
American Airlines
Thu, Apr 16 - Thu, Apr 23
SYR
Syracuse
FLO
Florence
$640 Roundtrip, found 1 day ago
$640
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Apr 16 from Syracuse to Florence, returning Thu, Apr 23, priced at $640 found 1 day ago

Frequently asked questions

How much does a flight from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) cost?
You can find cheap one-way flights from $328 and cheap return flights from $546 Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) with Expedia. One-way flights typically cost between $256 and $557, and return flights often range between $468 and $1163. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
The cheapest month to fly from SYR to FLO is May when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
Enter SYR to FLO and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
American Airlines is one of the cheapest airlines offering connecting flights from Syracuse (SYR) to Florence (FLO) with a layover in Philadelphia Intl. (PHL), starting from around $468. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
To find a cheap flight from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
The earliest flight from Hancock Intl. (SYR) to Florence Regional (FLO) generally departs at around 5:10 AM, operated by American Airlines. This seasonal service is available in June, giving you an early start to explore Florence. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
The most popular departure times for flights from Hancock Intl. (SYR) to Florence Regional (FLO) are from 6am to 9am. About 44% of passengers prefer this time window. Many major carriers, including American Airlines, offer flights during this window. This timing works well because it allows you to travel early and arrive in Florence with plenty of time to explore.
How long does it take to fly from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
A flight from SYR to FLO with a layover takes around 4 hours 20 minutes, with the route covering approximately 646 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
Select the "Business class" and "First class" filters when looking for SYR to FLO flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) flight with Expedia?
It's easy to earn miles on a Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Florence from Hancock Intl. (SYR)?
From Hancock Intl. (SYR), you can fly into Florence Regional (FLO) and Peretola (FLR) in Florence. Some flights may connect through major hubs like Philadelphia Intl. (PHL), Ronald Reagan Washington National (DCA), O'Hare Intl. (ORD) before reaching Florence. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) at the last minute?
Typically, booking a last minute flight from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package?
Securing a Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional)?
If you booked your Syracuse, NY (SYR-Hancock Intl.) to Florence, SC (FLO-Florence Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Hancock Intl.
Destination airport
Florence Regional
Roundtrip price
$546
Distance
646 mi

Book with confidence

Syracuse to Florence Flights

The cheapest times to fly from Syracuse to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Syracuse to Florence are during the month of May. You can find some of the cheapest flights from Syracuse to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Syracuse to Florence

Sunday is one of the best days to book for cheap flights from Syracuse to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Syracuse to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Syracuse to Florence in 2026. You can also book with separate airlines for your outbound and return journeys, from $328 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Syracuse to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Syracuse to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Syracuse to Florence Flights

*Flight schedules are subject to change.

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*Available to One Key members.