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$144 Cheap Flights from Knoxville (TYS) to St. Louis (STL)

View $144 flight on Fri, Nov 13, 2026Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Knoxville to St. Louis (TYS-STL)

Prices were available within the past 7 days and start at $144 for one-way flights and $243 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Oct 10 - Tue, Oct 13
TYS
Knoxville
STL
St. Louis
$243 Roundtrip, found 2 days ago
$243
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Oct 10 from Knoxville to St. Louis, returning Tue, Oct 13, priced at $243 found 2 days ago
Southwest Airlines
Tue, Oct 20 - Sat, Oct 24
TYS
Knoxville
STL
St. Louis
$257 Roundtrip, found 5 days ago
$257
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Tue, Oct 20 from Knoxville to St. Louis, returning Sat, Oct 24, priced at $257 found 5 days ago
Southwest Airlines
Sat, Jan 16 - Sat, Jan 23
TYS
Knoxville
STL
St. Louis
$289 Roundtrip, found 1 day ago
$289
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Sat, Jan 16 from Knoxville to St. Louis, returning Sat, Jan 23, priced at $289 found 1 day ago
American Airlines
Mon, Oct 12 - Mon, Oct 19
TYS
Knoxville
STL
St. Louis
$299 Roundtrip, found 1 day ago
$299
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Oct 12 from Knoxville to St. Louis, returning Mon, Oct 19, priced at $299 found 1 day ago
Southwest Airlines
Tue, Oct 27 - Fri, Oct 30
TYS
Knoxville
STL
St. Louis
$300 Roundtrip, found 1 day ago
$300
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Tue, Oct 27 from Knoxville to St. Louis, returning Fri, Oct 30, priced at $300 found 1 day ago
American Airlines
Mon, Oct 12 - Mon, Oct 19
TYS
Knoxville
STL
St. Louis
$307 Roundtrip, found 1 day ago
$307
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Oct 12 from Knoxville to St. Louis, returning Mon, Oct 19, priced at $307 found 1 day ago
Delta
Wed, Nov 4 - Wed, Nov 11
TYS
Knoxville
STL
St. Louis
$309 Roundtrip, just found
$309
Roundtrip
just found
Select Delta flight, departing Wed, Nov 4 from Knoxville to St. Louis, returning Wed, Nov 11, priced at $309 just found
United
Sat, Oct 10 - Tue, Oct 13
TYS
Knoxville
STL
St. Louis
$309 Roundtrip, found 2 days ago
$309
Roundtrip
found 2 days ago
Select United flight, departing Sat, Oct 10 from Knoxville to St. Louis, returning Tue, Oct 13, priced at $309 found 2 days ago
Southwest Airlines
Wed, Nov 4 - Wed, Nov 11
TYS
Knoxville
STL
St. Louis
$314 Roundtrip, just found
$314
Roundtrip
just found
Select Southwest Airlines flight, departing Wed, Nov 4 from Knoxville to St. Louis, returning Wed, Nov 11, priced at $314 just found
Southwest Airlines
Wed, Nov 4 - Wed, Nov 11
TYS
Knoxville
STL
St. Louis
$317 Roundtrip, just found
$317
Roundtrip
just found
Select Southwest Airlines flight, departing Wed, Nov 4 from Knoxville to St. Louis, returning Wed, Nov 11, priced at $317 just found

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $627
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $627

Find the cheapest month to fly from Knoxville (TYS) to St. Louis (STL)

February is typically the cheapest month to fly

From $180 - $278 per traveler.

What you need to know for your flight from McGhee Tyson to Lambert-St. Louis Intl.

Knoxville (TYS) to St. Louis (STL) at a glance

Travel from Knoxville (TYS) to St. Louis (STL) with a selection of airlines catering to this short domestic route. You can find flights from Knoxville that suit your budget and schedule, whether you prefer full-service or low-cost options. As you plan your visit to St. Louis and its iconic attractions, be sure to compare choices that best align with your travel needs. Check out the essential details for flights from McGhee Tyson Airport to Lambert-St. Louis International Airport.

  • Fastest flight duration: around 3h 30m in-flight, plus roughly 1h 15m layover with one stop
  • Route distance: roughly 400 miles (645 km)
  • Flights per week: around 10 departures on average
  • Typical fares (one-way): economy tickets often range from $105–$395, depending on seasonality and how far ahead you book

Flights from McGhee Tyson Airport (TYS) to Lambert-St. Louis International Airport (STL)

Based on the latest traveler bookings, here are the top airlines favored for one-stop flights from Knoxville to St. Louis. Many passengers opt for layovers at Hartsfield-Jackson Atlanta International Airport (ATL, approximately 1 hour 30 minutes), Charlotte-Douglas International Airport (CLT, about 1 hour), and O'Hare International Airport (ORD, roughly 1 hour 30 minutes). This variety allows you to balance price, total travel time, and cabin class to create the ideal itinerary for your journey.

  • American Airlines: This full-service airline provides one-stop flights, typically offering one-way fares ranging from $105 to $385. It dominates this route with about 50% of departures, featuring an in-flight duration of 3 hours and 30 minutes, and a total travel time of approximately 4 hours and 45 minutes, including layover.
  • Delta: Another full-service option, Delta also offers one-stop services with one-way ticket prices generally between $105 and $370. It accounts for roughly 34% of the departures on this route, with a flight time of 3 hours and 30 minutes, culminating in a total journey time of around 4 hours and 45 minutes (layover included).
  • United: As a full-service airline, United provides one-stop services with one-way fares that usually range from $120 to $450. It represents about 12% of the departures for this route, with an in-flight time of 3 hours and 30 minutes and an overall travel duration of roughly 4 hours and 45 minutes, factoring in the layover.
  • Southwest Airlines: Known for its low-cost offerings, Southwest Airlines features one-stop service with one-way fares typically between $120 and $295. It holds a smaller share of the market with around 4% of departures, providing an in-flight time of 3 hours and 30 minutes and a total travel time of approximately 4 hours and 45 minutes, including layover.

Travelers flying from Knoxville to St. Louis can opt for an upgrade, as American Airlines provides first-class service on this route.

Best time to fly from Knoxville (TYS) to St. Louis (STL)

The most popular months for travelers flying from Knoxville to St. Louis are January, February, and April, when peak temperatures in St. Louis reach up to 56.1°F in April. If you prefer quieter travel, consider December, the least busy time to visit with temperatures around 37.8°F and typically the lowest average one-way fare (around $189). Flight availability peaks in February, April, July, September, October, and November, with approximately 11 flights per week, making it easier to find convenient departure times. August has the fewest flights, with approximately 7 flights per week.

  • Cheapest time to fly: December usually offers good deals with average one-way fare around $189, roughly 11% cheaper than the yearly average.
  • More budget-friendly months to fly: August, February, and May typically offer average one-way fares of around $196.
  • Most flight options: February, April, July, September, October, and November have the highest number of flights from Knoxville to St. Louis, with approximately 11 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January31.6°F (-0.2°C)High10$214
February34.9°F (1.6°C)High11$197
March46.4°F (8.0°C)Average9$231
April56.1°F (13.4°C)High11$200
May66.6°F (19.2°C)Low8$197
June76.1°F (24.5°C)Average9$228
July78.6°F (25.9°C)Average11$224
August77.0°F (25.0°C)Low7$195
September70.9°F (21.6°C)Average11$202
October58.6°F (14.8°C)Average11$238
November46.2°F (7.9°C)Average11$240
December37.8°F (3.2°C)Low10$189

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative routes from Knoxville (TYS) to St. Louis (STL)

  • Knoxville to St. Louis (TYS-SUS): Spirit of St. Louis Airport (SUS) lies approximately 16 miles from Lambert-St. Louis International Airport (STL).
  • Knoxville to St. Louis (TYS-CPS): St. Louis Downtown Airport (CPS) is located around 16 miles from Lambert-St. Louis International Airport (STL).
  • Gatlinburg to St. Louis (GKT-STL): Gatlinburg - Pigeon Forge Airport (GKT) is roughly 26 miles away from McGhee Tyson Airport (TYS).

How to find the best prices for flights from Knoxville (TYS) to St. Louis (STL)

Getting some of the best deals on flights from Knoxville to St. Louis is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually available when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Morning departures between 5 AM and noon often provide lower prices and are the most sought-after flight times. Additionally, flying on Tuesday typically results in cheaper tickets, although Thursday remains the most popular day for travel.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Lambert-St. Louis International Airport from McGhee Tyson Airport

St. Louis welcomes travelers from Knoxville with a range of transport options based on price, convenience, and proximity. For departures, McGhee Tyson Airport is roughly a 20-minute drive (covering about 15 miles) from central Knoxville. Here's how to reach St. Louis efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in St. Louis, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Lambert-St. Louis International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Lambert-St. Louis International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From Lambert-St. Louis International Airport, Lambert Main Terminal Station, a metro station, is conveniently located just 0.1 miles away and easily accessible on foot.

Frequently asked questions

How much does a flight from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.) cost?
You can find cheap one-way flights from $144 and cheap return flights from $243 Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.) with Expedia. One-way flights usually range from $149 to $592, and return flights typically cost between $297 and $1026. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
August is the cheapest month to fly from Knoxville, TN (TYS) to St. Louis, MO (STL), with average round-trip fares around $267. This is about 22% lower than the average price throughout the year, as demand typically decreases during the late summer. Other budget-friendly months include January and February.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Enter TYS to STL and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Southwest is one of the cheapest airlines offering connecting flights from Knoxville, TN (TYS) to St. Louis, MO (STL), with round-trip tickets starting from around $278. This flight includes a layover in Baltimore Washington Intl. (BWI). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
To find a cheap flight from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
For flights from Knoxville (TYS) to St. Louis (STL), August and February are the best months to consider. August is the cheapest month with return flights averaging around $267, while February is also a good option for travelers looking for lower fares. This balance of price and availability is based on booking data from the past year, helping you choose the right time for your journey.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The earliest flight from McGhee Tyson Airport (TYS) to Lambert-St. Louis International Airport (STL) typically departs at around 5:00 AM local time, operated by American Airlines. This seasonal service is available in March, allowing you to start your day early and enjoy more time in St. Louis. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The most popular departure times for flights from Knoxville, TN (TYS) to St. Louis, MO (STL) are in the early afternoon, from 12pm to 3pm. About 21% of passengers choose this time window. American Airlines, United Airlines, and Delta Airlines provide flights during this window. This timing works well as it allows travelers to enjoy their morning before departing.
How long does it take to fly from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Flights from TYS to STL with one stop typically take around 6 hours 20 minutes, covering approximately 405 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
First class seats are offered on the TYS to STL route. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight with Expedia?
It's easy to earn miles on a Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for St. Louis from McGhee Tyson (TYS)?
From McGhee Tyson (TYS), you can fly into Lambert-St. Louis Intl. (STL) to reach St. Louis. Some flights may connect through major hubs like Washington Dulles Intl. (IAD), Charlotte-Douglas Intl. (CLT), Hartsfield-Jackson Atlanta Intl. (ATL) before reaching St. Louis. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.) at the last minute?
Typically, booking a last minute flight from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight and hotel package?
Securing a Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.) St Louis Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
If you booked your Knoxville, TN (TYS-McGhee Tyson) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
McGhee Tyson
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$242
Distance
404 mi

Book with confidence

Knoxville to St. Louis Flights

The cheapest times to fly from Knoxville to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to St. Louis are during the month of October. You can find some of the cheapest flights from Knoxville to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to St. Louis

Sunday is one of the best days to book for cheap flights from Knoxville to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to St. Louis in 2026. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to St. Louis Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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