A calm river with clear water, surrounded by dense trees and rocky banks.

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Our top choices for O Brien 2-star hotels

A spacious living area with a grey sofa, a coffee table, and a TV stand.

1. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,136 reviews)
"Nice staff great rooms"
United States
Ashlee
$80 nightly
The price is $90
Dec 1 - Dec 2
Total with taxes and fees
Best Western Plus Lake City
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

2. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"Overall great stay!"
United States
Jim
$95 nightly
The price is $107
Dec 6 - Dec 7
Total with taxes and fees
Comfort Suites Lake City
A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.

3. Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.2 out of 10, Very good, (1,000 reviews)
"Very nice hotel!"
United States
Mary
$71 nightly
The price is $80
Dec 1 - Dec 2
Total with taxes and fees
Quality Inn Lake City
A hotel room with two beds, a desk, a chair, a lamp, and a view of the outdoors.

4. Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283
2.5 star property
Live Oak
7.0 out of 10, Good, (600 reviews)
"Everything good"
United States
Guillermo
$84 nightly
The price is $92
Nov 22 - Nov 23
Total with taxes and fees
Quality Inn & Suites Live Oak I-10 Exit 283
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

5. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,005 reviews)
"Clean and well maintained hotel"
United States
Carlos
$93 nightly
The price is $105
Dec 6 - Dec 7
Total with taxes and fees
Tru by Hilton Lake City
A spacious indoor area with a pool view, multiple seating arrangements, and a central plant.

6. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"I have stayed here several times. Staff is at least very friendly and accommodating properties very clean. We enjoyed our stay."
United States
Eileen
$105 nightly
The price is $113
Dec 6 - Dec 7
Total with taxes and fees
Hampton Inn & Suites Lake City
A reception area with a counter, seating, and a fireplace.

7. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very good, (901 reviews)
"Nice place"
United States
Andrew
$105 nightly
The price is $116
Dec 6 - Dec 7
Total with taxes and fees
Holiday Inn Express & Suites Live Oak by IHG
A hotel room with two beds, a desk, a chair, a sink, and a painting of a pier and sunset.

8. Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.2 out of 10, Good, (1,007 reviews)
"The staff was very friendly checking in and checking out. The room was cleaned and well maintained."
United States
William
$60 nightly
The price is $68
Nov 15 - Nov 16
Total with taxes and fees
Days Inn by Wyndham Lake City I-10
A hotel lobby with a view of the street, a reception desk, and a large map on the wall.

9. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"This is a great hotel for the price. Clean, room was small. Close to restaurants and parking lot is well lite."
United States
Brenda
$71 nightly
The price is $80
Nov 15 - Nov 16
Total with taxes and fees
Americas Best Value Inn Lake City
A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.

10. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.2 out of 10, (1,000 reviews)
"Easy parking room clean"
United States
Pennee
$58 nightly
The price is $65
Nov 12 - Nov 13
Total with taxes and fees
Baymont by Wyndham Lake City I-75
A reception area with a stone wall, a reception desk, a leather chair, and a large window.

11. Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
7.4 out of 10, Good, (250 reviews)
"Amazing stay"
United States
Pennee
$73 nightly
The price is $82
Dec 1 - Dec 2
Total with taxes and fees
Motel 6 – Lake City, Fl – Medical Center
A modern kitchen area with a central counter, various food stations, and a chalkboard menu.

12. Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (572 reviews)
"Great breakfast!"
United States
Pamela
$111 nightly
The price is $125
Nov 18 - Nov 19
Total with taxes and fees
Hampton Inn & Suites Alachua I-75
A hotel room with two beds, a TV, a desk, and a painting of a sunset.

13. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,000 reviews)
"Nice breakfast."
United States
Nathan
$67 nightly
The price is $76
Dec 1 - Dec 2
Total with taxes and fees
Days Inn by Wyndham Lake City I-75
A modern kitchen with a large window, a flat-screen TV, and a coffee machine.

14. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (710 reviews)
"Great breakfast options quiet clean place to stay"
United States
Pennee
$60 nightly
The price is $66
Dec 2 - Dec 3
Total with taxes and fees
Quality Inn White Springs Suwanee
A hotel room with two beds, a blue wall, and a window with curtains.

15. Gateway Inn

Gateway Inn
2.5 star property
Lake City
7.8 out of 10, Good, (213 reviews)
"Nice modern, clean hotel room"
United States
Karen
$49 nightly
The price is $55
Nov 15 - Nov 16
Total with taxes and fees
Gateway Inn
A hotel room with a bed, a desk, a chair, a refrigerator, and a microwave.

16. Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.6 out of 10, Good, (665 reviews)
"great family frindley inn. great rates.3 foods close to inn.walking distance to"
United States
Ron
$69 nightly
The price is $78
Nov 12 - Nov 13
Total with taxes and fees
Palms Garden Inn
A stone water feature with cascading water, surrounded by a brick wall and greenery.

17. BlueGem Motel

BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (488 reviews)
"Very clean rooms and homey atmosphere!"
United States
Myra
$96 nightly
The price is $108
Dec 8 - Dec 9
Total with taxes and fees
BlueGem Motel
A hotel reception area with a reception desk, seating area, and a view of the parking lot.

18. Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (327 reviews)
"I definitely will not recommend anyone to book a room there. The rooms are in bad sharp. The whole hotel need remodel."
United States
Alexia
$73 nightly
The price is $80
Nov 15 - Nov 16
Total with taxes and fees
Econo Lodge Live Oak
A hotel room with two beds, a desk, a chair, and a television.

19. Royal Inn

Royal Inn
2.0 star property
Alachua
7.2 out of 10, Good, (208 reviews)
"Bugs in room"
United States
James
$70 nightly
The price is $79
Nov 12 - Nov 13
Total with taxes and fees
Royal Inn
A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.

20. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (767 reviews)
"Complimentary dinner and cooked to order eggs at breakfast. Neat and clean. Comfy bed."
United States
Allan
$61 nightly
The price is $69
Dec 1 - Dec 2
Total with taxes and fees
Super 8 by Wyndham Lake City
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Explore similar 3-star hotels

Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in O Brien.
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

165NW CALI DRIVE Lake City FL
$94 nightly
The price is $105 total per night from Dec 2 to Dec 3
$105 total
Dec 2 - Dec 3
Total with taxes and fees
8.8/10 Excellent! (1,209 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

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O Brien Motel Guide

Planning a getaway with only a few bucks to spare? Expedia can help! With the inexpensive rates at the top motels in O Brien, Florida you can put together the vacation of your dreams without spending every penny of your yearly travel budget.

These smaller places are ideal if you need a home base that lets you easily explore the local sights; many of the best motels in O Brien are located near major freeways and public transportation. Plus, when you book a cheap deal on a motel in O Brien, you’ll find quiet rooms, complimentary toiletries, and comfortable sleeping areas, so you can unwind after a long day.

No matter which motel you choose, don't forget to use the travel tools at Expedia to search for local discounts, compare rates on the hottest motels, and plan your next vacation. You won't believe how budget-friendly an amazing getaway can be.

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