The Best 4 Star Hotels in Big Pine Key, FL from $225

A calm river with boats, lush greenery, and a clear blue sky.

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Our top choices for Big Pine Key 4-star hotels

Premium bedding, pillowtop beds, in-room safe, desk

1. Tranquility Bay Beachfront Hotel and Resort

Marathon

Robert

$264 nightly

$297 total

Aug 30 - Aug 31

Total with taxes and fees

Steam room, body treatments, aromatherapy, hot stone massages

4 restaurants; breakfast, lunch, dinner, and brunch served

2. Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Marathon

joanne

$221 nightly

$249 total

Aug 11 - Aug 12

Total with taxes and fees

Standard Room, Ocean View - Adults Only | Hypo-allergenic bedding available, blackout drapes, iron/ironing board

Rooftop bar, ocean views, open select days

Deluxe Room, 1 King Bed, Oceanfront - Adults Only | Beach/ocean view

3. Grassy Flats Resort & Beach Club

Marathon

Lucas

$200 nightly

$225 total

Sep 7 - Sep 8

Total with taxes and fees

Townhome, Marina View | Living area | Flat-screen TV

4. Marlin Bay Resort & Marina

Marathon

Chardell

Luxury Villa, 3 Bedrooms, Balcony, Overwater | Terrace/patio

Luxury Villa, 3 Bedrooms, Balcony, Overwater | In-room dining

5. Waterfront Luxury Villa

Marathon Shores

Villa, 3 Bedrooms | Living room | 36-inch TV with cable channels

6. Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax

Marathon Shores

7. Indigo Reef Marina Pet Friendly Homes by Pack and Relax

Marathon

8. Indigo Reef Marina Homes by Pack and Relax

Marathon

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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Big Pine Key.

Isla Bella Beach Resort & Spa

1 Knights Key Boulevard Marathon FL

$303 nightly

$341 total

Aug 18 - Aug 19

Total with taxes and fees

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Pool Spa Hot tub Breakfast included Waterpark

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key

A beach with clear turquoise water, a red umbrella, and a bridge in the background.

Top Big Pine Key Hotel Reviews

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

10/10 Excellent

"Excelente atención, servicios, amenidsdes 100% recomendado"

Tranquility Bay Beachfront Hotel and Resort

8/10 Good

"Very good setting and good ideas/resort layout. When we arrived to check in, reception couldnt find our booking so took longer than expected. We asked about the sunset boat tour at reception but were told this was a third party on the beach who close at 5 so unable to get further info, would be good if the reception staff could provide more information or take bookings as they are advertising it. Food and drink at the hotel are expensive. General buildings and rooms could do with a bit of tidying up in places. Fire alarm panel in the building we were staying in was beeping with a fault most of the night so didnt manage to sleep too well."

Find out more about Big Pine Key

Big Pine Key Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Big Pine Key, Florida are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Big Pine Key 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Big Pine Key. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Big Pine Key, Florida, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Big Pine Key hotels offer everything your heart desires.

Frequently asked questions

What are the best 4-star hotels in Big Pine Key?

Make unforgettable vacation memories in Big Pine Key at Little Palm Island Resort & Spa - A Noble House Resort. Highly recommended by Expedia travelers, this 4-star hotel offers lots of amenities for a comfortable and relaxing stay.

How much does it cost to stay in a 4-star hotel in Big Pine Key?

To book a 4-star hotel in Big Pine Key that fits your budget, take advantage of Expedia's filters. Check out what's available during your preferred dates and use our pricing filter to set your limit. You can also sort your results by the cheapest property first.

Search for the lowest price from $341

What's the difference between 5-star and 4-star hotels in Big Pine Key?

If you decide to vacation at a 4-star hotel in Big Pine Key, you'll usually find plenty of amenities to keep you relaxed, such as a pool, restaurant and gym. You can enjoy excellent service and upscale accommodations. Pick a 5-star hotel and you'll get a few extra perks — think on-site spas, concierge assistance and opulent turndown services. You're likely to get additional amenities and first-class services at a 5-star stay, but both are great options for luxury travelers.

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Check availability on Big Pine Key 4 Star Hotels

Our top choices for Big Pine Key 4-star hotels

1. Tranquility Bay Beachfront Hotel and Resort