Find 4 Star Hotels in Big Pine Key, FL from $442

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Our top choices for Big Pine Key 4-star hotels

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
4.0 star property
Marathon
8.8 out of 10, Excellent, (1,001 reviews)
"We stayed in a villa and enjoyed the water activities, plus Publix is nearby! We rested, recharged in a secure and peaceful environment… truly magical."
United States
Frances
$408 nightly
The price is $459
Mar 22 - Mar 23
Total with taxes and fees
Tranquility Bay Beachfront Hotel and Resort

Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club
4.0 star property
Marathon
9.4 out of 10, Exceptional, (418 reviews)
"Every single part of our stay at Grassy Flats was 5/5! Staff, room, ocean view, pool, dining, market, beach, etc. highly recommend!"
Canada
KAREN
$393 nightly
The price is $442
Apr 16 - Apr 17
Total with taxes and fees
Grassy Flats Resort & Beach Club

The Reef at Marathon, Florida Keys

The Reef at Marathon, Florida Keys
4.0 star property
Marathon
9.0 out of 10, Wonderful, (14 reviews)
"We enjoyed the pool, canoe, parking right near the unit. Clean, had everything you needed. Centrally located in the middle of the keys. "
United States
Linda L
The Reef at Marathon, Florida Keys

Marlin Bay Resort & Marina

Marlin Bay Resort & Marina
4.0 star property
Marathon
10.0 out of 10, Exceptional, (2 reviews)
"Wonderful vacation!"
United States
Chardell
Marlin Bay Resort & Marina

Waterfront Luxury Villa

Waterfront Luxury Villa
4.0 star property
Marathon Shores
Waterfront Luxury Villa

Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax

Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
4.0 star property
Marathon Shores
Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax

Indigo Reef Marina Pet Friendly Homes by Pack and Relax

Indigo Reef Marina Pet Friendly Homes by Pack and Relax
4.0 star property
Marathon
Indigo Reef Marina Pet Friendly Homes by Pack and Relax

Indigo Reef Marina Homes by Pack and Relax

Indigo Reef Marina Homes by Pack and Relax
4.0 star property
Marathon
Indigo Reef Marina Homes by Pack and Relax
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Big Pine Key.
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

1 Knights Key Boulevard Marathon FL
$514 nightly
The price is $579 total per night from Apr 17 to Apr 18
$579 total
Apr 17 - Apr 18
Total with taxes and fees
9.2/10 Wonderful! (1,100 reviews)
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Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

Bahia Honda State Park showing general coastal views, a bridge and a beach

Top Big Pine Key Hotel Reviews

Find out more about Big Pine Key

Big Pine Key Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Big Pine Key, Florida are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Big Pine Key 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Big Pine Key. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Big Pine Key, Florida, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Big Pine Key hotels offer everything your heart desires.

Frequently asked questions

What are the best 4-star hotels in Big Pine Key?
Make unforgettable vacation memories in Big Pine Key at Little Palm Island Resort & Spa - A Noble House Resort. Highly recommended by Expedia travelers, this 4-star hotel offers lots of amenities for a comfortable and relaxing stay.
How much does it cost to stay in a 4-star hotel in Big Pine Key?
To book a 4-star hotel in Big Pine Key that fits your budget, take advantage of Expedia's filters. Check out what's available during your preferred dates and use our pricing filter to set your limit. You can also sort your results by the cheapest property first.

  • Search for the lowest price from $579

What's the difference between 5-star and 4-star hotels in Big Pine Key?
If you decide to vacation at a 4-star hotel in Big Pine Key, you'll usually find plenty of amenities to keep you relaxed, such as a pool, restaurant and gym. You can enjoy excellent service and upscale accommodations. Pick a 5-star hotel and you'll get a few extra perks — think on-site spas, concierge assistance and opulent turndown services. You're likely to get additional amenities and first-class services at a 5-star stay, but both are great options for luxury travelers.

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