Find 4 Star Hotels in Big Pine Key, FL from $222
Upfront pricingOur total price for your stay includes taxes and fees
Treat yourselfSave 10% or more on over 100,000 hotels worldwide with Member PricesLearn about One Key
Be pickySearch almost a million properties worldwide
Check availability on Big Pine Key 4 Star Hotels
Tonight
Aug 7 - Aug 8Tomorrow
Aug 8 - Aug 9This weekend
Aug 7 - Aug 9Next weekend
Aug 14 - Aug 16Our top choices for Big Pine Key 4-star hotels
1. Tranquility Bay Beachfront Hotel and Resort
Tranquility Bay Beachfront Hotel and ResortMarathon
Robert
$264 nightly
$297 total
Aug 27 - Aug 28
Total with taxes and fees
2. Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
Faro Blanco Resort Marathon Florida Keys, Curio by HiltonMarathon
joanne
$221 nightly
$249 total
Aug 10 - Aug 11
Total with taxes and fees
$197 nightly
$222 total
Aug 11 - Aug 12
Total with taxes and fees
5. Waterfront Luxury Villa
Waterfront Luxury VillaMarathon Shores
6. Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
Indigo Reef Marina Homes Close to Boat Slip by Pack and RelaxMarathon Shores
7. Indigo Reef Marina Pet Friendly Homes by Pack and Relax
Indigo Reef Marina Pet Friendly Homes by Pack and RelaxMarathon
8. Indigo Reef Marina Homes by Pack and Relax
Indigo Reef Marina Homes by Pack and RelaxMarathon
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Big Pine Key.
Isla Bella Beach Resort & Spa
1 Knights Key Boulevard Marathon FL
$257 nightly
$289 total
Aug 18 - Aug 19
Total with taxes and fees
Still don't see what you're looking for?
See all properties in Big Pine Key.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Big Pine Key
Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.
See all hotels in Big Pine Key
Top Big Pine Key Hotel Reviews
Tranquility Bay Beachfront Hotel and Resort
8/10 Good
"Very good setting and good ideas/resort layout. When we arrived to check in, reception couldnt find our booking so took longer than expected. We asked about the sunset boat tour at reception but were told this was a third party on the beach who close at 5 so unable to get further info, would be good if the reception staff could provide more information or take bookings as they are advertising it. Food and drink at the hotel are expensive. General buildings and rooms could do with a bit of tidying up in places. Fire alarm panel in the building we were staying in was beeping with a fault most of the night so didnt manage to sleep too well."
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
10/10 Excellent
"Great location"
Find out more about Big Pine Key
Big Pine Key Four Star Hotel Information
When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Big Pine Key, Florida are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Big Pine Key 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.
Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Big Pine Key. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Big Pine Key, Florida, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.
Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Big Pine Key hotels offer everything your heart desires.
Frequently asked questions
What are the best 4-star hotels in Big Pine Key?
Make unforgettable vacation memories in Big Pine Key at Little Palm Island Resort & Spa - A Noble House Resort. Highly recommended by Expedia travelers, this 4-star hotel offers lots of amenities for a comfortable and relaxing stay.
How much does it cost to stay in a 4-star hotel in Big Pine Key?
To book a 4-star hotel in Big Pine Key that fits your budget, take advantage of Expedia's filters. Check out what's available during your preferred dates and use our pricing filter to set your limit. You can also sort your results by the cheapest property first.
- Search for the lowest price from $289
What's the difference between 5-star and 4-star hotels in Big Pine Key?
If you decide to vacation at a 4-star hotel in Big Pine Key, you'll usually find plenty of amenities to keep you relaxed, such as a pool, restaurant and gym. You can enjoy excellent service and upscale accommodations. Pick a 5-star hotel and you'll get a few extra perks — think on-site spas, concierge assistance and opulent turndown services. You're likely to get additional amenities and first-class services at a 5-star stay, but both are great options for luxury travelers.
Explore a world of travel with Expedia
- Key West Hotels
- 5 Star Hotels in Little Venice
- Resorts in Key West
- 2 Star Hotels in Key West
- 3 Star Hotels in Key West
- Islamorada Hotels
- Motels in Big Pine Key
- 5 Star Hotels in Summerland Key
- 3 Star Hotels in No Name Key
- Cheap Hotels in Key West
- 5 Star Hotels in Stock Island
- 5 Star Hotels in Big Pine Key
- 2 Star Hotels in Punta Brisa
- 4 Star Hotels in Stock Island
- Hotels near Duval Street
- All-Inclusive Resorts in Key West
- 5 Star Hotels in Marathon
- 4 Star Hotels in Tingler Island
- 4 Star Hotels in Dredgers Key
- 5 Star Hotels in Duck Key
- Cabin Rentals in Big Pine Key
- 4 Star Hotels in Ramrod Key
- Oceanfront Hotels in Key West
- 2 Star Hotels in Bahia Honda Key
- 3 Star Hotels in Lower Florida Keys
- Adults Only Resorts & in Key West
- Resorts in Big Pine Key
- 4 Star Hotels in Bahia Honda Key
- 4 Star Hotels in Duck Key
- Key West Historic District Hotels
- 4 Star Hotels in Key West Historic District
- 3 Star Hotels in Marathon
- Cheap Hotels in Big Pine Key
- Oceanfront Hotels in Marathon
- 3 Star Hotels in Big Pine Key
- 2 Star Hotels in Marathon
- 4 Star Hotels in Whispering Pines
- 3 Star Hotels in Middle Torch Key
- 4 Star Hotels in Sugarloaf Shores
- Summerland Key Hotels
- 4 Star Hotels in Marathon
- 4 Star Hotels in Key West
- Rv Parks in Big Pine Key
- Houseboats in Key West
- 5 Star Hotels in Bahia Honda Key
- 4 Star Hotels in Old Town Key West
- Big Pine Key Hotels
- 2 Star Hotels in Key Colony Beach
- Flights from Key West Intl.
- Flights from Chicago (ORD) to Key West (EYW)
- Flights from Fort Lauderdale (FLL) to Key West (EYW)
- Flights to Marathon
- Flights from Philadelphia (PHL) to Key West (EYW)
- Flights from Tampa (TPA) to Key West (EYW)
- Flights to Key West
- Flights from Atlanta (ATL) to Key West (EYW)
- Flights from Orlando (MCO) to Key West (EYW)
- Flights from Florida Keys Marathon
- Flights from West Palm Beach (PBI) to Key West (EYW)
- Flights from Jacksonville (JAX) to Key West (EYW)
- Flights to Big Pine Key
- Flights from New York (JFK) to Key West (EYW)
- Flights from Charlotte (CLT) to Key West (EYW)
- Flights from Boston (BOS) to Key West (EYW)
- Flights from Baltimore (BWI) to Key West (EYW)
- Flights from Pittsburgh (PIT) to Key West (EYW)
- Flights from Raleigh (RDU) to Key West (EYW)
- Flights from Newark Liberty Intl. Airport (EWR) to Key West (EYW)
- Flights from Washington (DCA) to Key West (EYW)
- Flights from Nashville (BNA) to Key West (EYW)
- Flights from Fort Myers (RSW) to Key West (EYW)
- Flights from St. Louis (STL) to Key West (EYW)
- Flights from Detroit (DTW) to Key West (EYW)
- Flights from Minneapolis (MSP) to Key West (EYW)
- Flights from Miami (MIA) to Key West (EYW)
- Flights from Dallas (DFW) to Key West (EYW)