A calm river with boats, lush greenery, and a clear blue sky.

Find 5 Star Hotels in Big Pine Key, FL from $217

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Check availability on Big Pine Key 5 Star Hotels

This weekend
Jul 31 - Aug 2
Next weekend
Aug 7 - Aug 9

Our top choices for Big Pine Key 5-star hotels

On the beach, sun loungers, beach umbrellas, beach towels

1. Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1,209 reviews)
"Beautiful property with stunning water views from the rooms and restaurant."
United States
Ryan
$247 nightly
The price is $277
Aug 30 - Aug 31
Total with taxes and fees
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

1996 Overseas Highway Marathon FL
$193 nightly
The price is $217 total per night from Aug 17 to Aug 18
$217 total
Aug 17 - Aug 18
Total with taxes and fees
8.6/10 Excellent! (1,167 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
A beach with clear turquoise water, a red umbrella, and a bridge in the background.

Top Big Pine Key Hotel Reviews

Find out more about Big Pine Key

Pamper your every desire on your upcoming sabbatical. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Big Pine Key so popular in the last year. There's no reason to delay a getaway to Big Pine Key any longer. Furthermore, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. Book one of Expedia's luxurious 5-star hotels in Big Pine Key and get ready to enjoy the getaway of a lifetime. Don't wait any longer!

Get a Great Deal on 5-Star Hotels in Big Pine Key

Don't be afraid to request the best service from your hotel, along with the best conditions. Exceptional service, delicious meals, and attentive guest service are all ready for you. You're sure to find exactly the accommodation you need. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What creature comforts do you want in your lodging? 24-hour room service, so you can order that chocolate soufflé© in the wee hours of the morning? A reflexology treatment that will leave you feeling refreshed and alive? Butler services? No matter what you want on a perfect getaway, you're bound to find it here. Want to see for yourself? Plenty of visitors recommend this location.

But you aren't going to spend your entire vacation in your room, of course. We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Big Pine Key are waiting for you to relax after a busy day.

Make Your Escape

The results are in, and Big Pine Key 5-star hotels are the place to be when you book your next vacation. These beautiful hotels are highly rated by the guests who stay in them, and you're about to join their ranks. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Choose one of Expedia's Big Pine Key 5-star hotels today and relax in the lap of luxury tomorrow.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Big Pine Key?
You'll find a variety of pricing options for a 5-star hotel in Big Pine Key on Expedia. The amount you pay will depend on when you travel, length of your trip and other factors. Compare available properties for your desired dates and use our pricing and other filters to score the perfect high-end stay.

  • Search for the lowest price per night from $217

What makes a hotel 5 stars in Big Pine Key?
Outstanding guest service characterizes every 5-star hotel in Big Pine Key. From the moment you arrive, staff are at your beck and call, whether arranging valet parking or providing in-room massages. Additionally, hotels have to feature upscale amenities to meet the standard for a 5-star rating. These can include luxury bathrobes, saunas or spas, pools, gastronomic restaurants and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Big Pine Key?
Use Expedia's filter tool to find a high-end escape in Big Pine Key where everything you need is included in the price. From there, narrow down your results for properties that have a 5-star rating and are listed as "All inclusive." The most important thing to look forward to at these stays? Pure relaxation and indulgence.

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