Title: The Best 5 Star Hotels in Big Pine Key, FL from $387 | Expedia.com [Big Pine Key Travel Guide](https://expedia.com/Big-Pine-Key.dx7195)[Hotels in Big Pine Key](https://expedia.com/Big-Pine-Key-Hotels.d7195.Travel-Guide-Hotels)[Vacation Rentals in Big Pine Key](https://expedia.com/Big-Pine-Key-Vacation-Rentals.d7195.Travel-Guide-VacationRentals)[Flights to Big Pine Key](https://expedia.com/Cheap-Flights-To-Big-Pine-Key.d7195.Travel-Guide-Flights)[Things to do in Big Pine Key](https://expedia.com/Things-To-Do-In-Big-Pine-Key.d7195.Travel-Guide-Activities)[Car Rentals in Big Pine Key](https://expedia.com/Car-Rentals-In-Big-Pine-Key.d7195.Car-Rental-Guide)[Big Pine Key Vacation Packages](https://expedia.com/Big-Pine-Key.d7195.Destination-Travel-Guides) ![Bahia Honda State Park showing general coastal views, a bridge and a beach](https://images.trvl-media.com/place/7195/5947ed8f-07bf-40de-9b8f-70a7b9a8077a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/7195/5947ed8f-07bf-40de-9b8f-70a7b9a8077a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Big Pine Key 5 Star Hotels Tonight [Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=7195&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 7 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=7195&startDate=2026-02-07&endDate=2026-02-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=7195&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=7195&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Big Pine Key 5-star hotels ![On the beach, sun loungers, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/f6566b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/02a3a50c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/04484d29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/9f64224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Isla Bella Beach Resort & Spa [](https://www.expedia.com/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information) Marathon 9.2/10 Wonderful (1,084 reviews) "great resort " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Niki $408 nightly $460 total Feb 10 - Feb 11 Total with taxes and fees [](https://www.expedia.com/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Big-Pine-Key-Hotels.s50-0-d7195.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Big-Pine-Key-Hotels.s50-0-d7195.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key. ![Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton](https://images.trvl-media.com/lodging/2000000/1170000/1169600/1169583/16bbce87_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton 1996 Overseas Highway Marathon FL $344 nightly $387 total Mar 1 - Mar 2 Total with taxes and fees 8.6/10 Excellent! (1,230 reviews) [](https://expedia.com/Marathon-Hotels-Faro-Blanco-Resort-Yacht-Club.h1169583.Hotel-Information) ![Tranquility Bay Beachfront Hotel and Resort](https://images.trvl-media.com/lodging/1000000/120000/117100/117099/2efaf74f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Tranquility Bay Beachfront Hotel and Resort 2600 Overseas Hwy Marathon FL $507 nightly $570 total Mar 2 - Mar 3 Total with taxes and fees 8.8/10 Excellent! (1,002 reviews) [](https://expedia.com/Marathon-Hotels-Tranquility-Bay-Beachfront-Hotel-And-Resort.h117099.Hotel-Information) ![Marlin Bay Resort & Marina](https://images.trvl-media.com/lodging/117000000/116450000/116443200/116443145/cf2fb1a0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Marlin Bay Resort & Marina 3800 Gulfview Ave Marathon FL [Get rates](https://expedia.com/Hotel-Search?startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&selected=116443145&PinnedHotelID=116443145&HadPinnedHotel=true®ionId=7195) 10/10 Exceptional! (1 review) [](https://expedia.com/Marathon-Hotels-Marlin-Bay-Resort-Marina.h116443145.Hotel-Information) Still don't see what you're looking for? [See all properties in Big Pine Key.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F7%2F2026&endDate=2%2F8%2F2026®ionId=7195&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F7%2F2026&endDate=2%2F8%2F2026®ionId=7195&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F7%2F2026&endDate=2%2F8%2F2026®ionId=7195&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F7%2F2026&endDate=2%2F8%2F2026®ionId=7195&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F7%2F2026&endDate=2%2F8%2F2026®ionId=7195&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F7%2F2026&endDate=2%2F8%2F2026®ionId=7195&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Big Pine Key Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves. [See all hotels in Big Pine Key](https://www.expedia.com/Hotel-Search?startDate=2026-02-20&endDate=2026-02-21&adults=2®ionId=7195) ![Bahia Honda State Park showing general coastal views, a bridge and a beach](https://images.trvl-media.com/place/7195/5947ed8f-07bf-40de-9b8f-70a7b9a8077a.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Big Pine Key Hotel Reviews ![Isla Bella Beach Resort & Spa](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/f4f56036_y.jpg) ### Isla Bella Beach Resort & Spa 10/10 Excellent "Great staff, first rate property. Food was outstanding." [](https://expedia.com/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information) ## Find out more about Big Pine Key Pamper your every desire on your upcoming sabbatical. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Big Pine Key so popular in the last year. There's no reason to delay a getaway to Big Pine Key any longer. Furthermore, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. Book one of Expedia's luxurious 5-star hotels in Big Pine Key and get ready to enjoy the getaway of a lifetime. Don't wait any longer! ### Get a Great Deal on 5-Star Hotels in Big Pine Key Don't be afraid to request the best service from your hotel, along with the best conditions. Exceptional service, delicious meals, and attentive guest service are all ready for you. You're sure to find exactly the accommodation you need. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What creature comforts do you want in your lodging? 24-hour room service, so you can order that chocolate soufflé© in the wee hours of the morning? A reflexology treatment that will leave you feeling refreshed and alive? Butler services? No matter what you want on a perfect getaway, you're bound to find it here. Want to see for yourself? Plenty of visitors recommend this location. But you aren't going to spend your entire vacation in your room, of course. We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Big Pine Key are waiting for you to relax after a busy day. ### Make Your Escape The results are in, and Big Pine Key 5-star hotels are the place to be when you book your next vacation. These beautiful hotels are highly rated by the guests who stay in them, and you're about to join their ranks. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Choose one of Expedia's Big Pine Key 5-star hotels today and relax in the lap of luxury tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Big Pine Key? > - Search for the lowest price per night from $387 ### What makes a hotel 5 stars in Big Pine Key? ### Are there any 5-star all-inclusive resorts in Big Pine Key? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near National Key Deer Refuge Visitor Center ](https://www.expedia.com/National-Key-Deer-Refuge-Visitor-Center-Hotels.0-l553248635974766232-0.Travel-Guide-Filter-Hotels) - [Hotels near Big Pine Key Flea Market ](https://www.expedia.com/Big-Pine-Key-Flea-Market-Hotels.0-l553248621533115810-0.Travel-Guide-Filter-Hotels) - [Hotels near Sands ](https://www.expedia.com/Sands-Big-Pine-Key-Hotels.0-n553248635976470321-0.Travel-Guide-Filter-Hotels) - [Hotels near Whispering Pines ](https://www.expedia.com/Whispering-Pines-Big-Pine-Key-Hotels.0-n553248635976471032-0.Travel-Guide-Filter-Hotels) - 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