Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys Independent Hotels

See all 880 Hotels in Florida Keys
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
    4.0 out of 5.0
     
     
    4.5 out of 5 (475 reviews)
    Oceanside room All rooms have a view of the marina and ocean. Great place with six pools. Shuttle servic into down … - 
    Amara Cay Resort

    Amara Cay Resort

    80001 Overseas Hwy, Islamorada
      3.5 out of 5.0
       
       
      4.3 out of 5 (1,271 reviews)
      Stunning hotel Absolutely picture perfect. The room is beautiful. Ocean front suite - highly recommend. Food and d … - 

      Amara Cay Resort$182

      Amara Cay Resort$182
      Ibis Bay Beach Resort

      Ibis Bay Beach Resort

      3101 N. Roosevelt Blvd, Key West
        2.5 out of 5.0
         
         
        3.7 out of 5 (1,665 reviews)
        Chic, Clean, Comfortable! We spent one night at the Ibis and we were impressed. The lady checking us in was really friendly; … - 

        Ibis Bay Beach Resort$167

        Ibis Bay Beach Resort$167
        Havana Cabana at Key West

        Havana Cabana at Key West

        3420 N. Roosevelt Blvd, Key West
          3.5 out of 5.0
           
           
          3.9 out of 5 (7 reviews)
          The best experience that I had. Excellent staff. I remember my country Cuba . I felt in my hoyse. - 

          Havana Cabana at Key West$147

          Havana Cabana at Key West$147
          Banana Bay Resort & Marina

          Banana Bay Resort & Marina

          4590 Overseas Highway, Marathon
            3.0 out of 5.0
             
             
            3.5 out of 5 (1,424 reviews)
            Very nice Stayed here on a work trip with 3 coworkers. It was just what we needed, after spending a week at s … - 

            Banana Bay Resort & Marina$183

            Banana Bay Resort & Marina$183
            Margaritaville Key West Resort & Marina

            Margaritaville Key West Resort & Marina

            245 Front Street, Key West
              4.0 out of 5.0
               
               
              4.3 out of 5 (265 reviews)
              The staff at Margaritaville could not have been nicer! Loved the location right next to Mallory Squ … - 
              Creekside Inn Islamorada

              Creekside Inn Islamorada

              90611 Old Highway, Islamorada
                2.5 out of 5.0
                 
                 
                3.6 out of 5 (721 reviews)
                I liked The Creekside - so will you. A very nice combination of: 1. Seems to have been there a long time. 2. Substantially and expertly … - 

                Creekside Inn Islamorada$129

                Creekside Inn Islamorada$129
                Lime Tree Bay Resort

                Lime Tree Bay Resort

                68500 Overseas Hwy, Long Key
                  3.5 out of 5.0
                   
                   
                  4.1 out of 5 (624 reviews)
                  Good hotel We stayed in the condo on the other side of the road. Good, clean rooms, kitchen, everything you ne … - 

                  Lime Tree Bay Resort$119

                  Lime Tree Bay Resort$119
                  Bayside Inn Key Largo

                  Bayside Inn Key Largo

                  99490 Overseas Hwy, Key Largo
                    2.5 out of 5.0
                     
                     
                    3.0 out of 5 (1,777 reviews)
                    Good place to stay. Showers could use a upgrade. Private beach was great to use - 

                    Bayside Inn Key Largo$86

                    Bayside Inn Key Largo$86
                    Silver Palms Inn

                    Silver Palms Inn

                    830 Truman Ave, Key West
                      3.5 out of 5.0
                       
                       
                      4.5 out of 5 (1,841 reviews)
                      Recently updated but a little far from the action This was our first time in Key West. This hotel was very nice - rooms were spotless and bright, and … - 

                      Silver Palms Inn$199

                      Silver Palms Inn$199
                      Heron House Court - Adult Only

                      Heron House Court - Adult Only

                      412 Frances St, Key West
                        3.0 out of 5.0
                         
                         
                        4.4 out of 5 (1,427 reviews)
                        Wish we could have stayed longer... We will be back! Quiet, secluded and close to all shops, beach, bars... Staff is very accommodating … - 
                        Amy Slate's Amoray Dive Resort

                        Amy Slate's Amoray Dive Resort

                        104250 Overseas Hwy, Key Largo
                          2.0 out of 5.0
                           
                           
                          3.9 out of 5 (961 reviews)
                          Beautiful spot, overall nice stay. Bed was uncomfortable is all. - 

                          Amy Slate's Amoray Dive Resort$144

                          Amy Slate's Amoray Dive Resort$144
                          The Southernmost Inn-Adults Only

                          The Southernmost Inn-Adults Only

                          525 United Street, Key West
                            2.5 out of 5.0
                             
                             
                            4.1 out of 5 (943 reviews)
                            Nice, quiet boutique hotel, close to Duval, but wi I have stayed here before. This suits me, as it is tranquil, clean and relaxing. Room was great wit … - 

                            The Southernmost Inn-Adults Only$169

                            The Southernmost Inn-Adults Only$169
                            Southwinds Motel

                            Southwinds Motel

                            1321 Simonton Street, Key West
                              2.0 out of 5.0
                               
                               
                              3.9 out of 5 (842 reviews)
                              Nice beach hotel Room was dark and air conditioner blows directly on you while you sleep. That’s the only problem. S … - 

                              Southwinds Motel$168

                              Southwinds Motel$168
                              The Perry Hotel Key West

                              The Perry Hotel Key West

                              7001 Shrimp Road, Key West
                                4.0 out of 5.0
                                 
                                 
                                4.6 out of 5 (150 reviews)
                                funky friendly hotel Great location at the marina, with funky bars and restaurant. Nice decor and design. Room had nice … - 
                                Skipjack Resort & Marina

                                Skipjack Resort & Marina

                                19 Sombrero Blvd, Marathon
                                  3.0 out of 5.0
                                   
                                   
                                  4.1 out of 5 (196 reviews)
                                  Convenient Location in Marathon The room, actually suite, was well decorated and clean. It was nice to have a small kitchen area an … - 

                                  Skipjack Resort & Marina$179

                                  Skipjack Resort & Marina$179
                                  Chelsea House Hotel - Key West

                                  Chelsea House Hotel - Key West

                                  709 Truman Ave, Key West
                                    2.5 out of 5.0
                                     
                                     
                                    4.2 out of 5 (667 reviews)
                                    great location the room was very nice close to pool and wonderful cont. breakfast. staff very cordial. they let us … - 

                                    Chelsea House Hotel - Key West$199

                                    Chelsea House Hotel - Key West$199
                                    Chesapeake Beach Resort

                                    Chesapeake Beach Resort

                                    83409 Overseas Hwy, Islamorada
                                      2.5 out of 5.0
                                       
                                       
                                      3.8 out of 5 (566 reviews)
                                      Still coming back from Hurricane Irma Room was clean. New towels. Noisy A/C. Pool open. Beach closed due to construction on ocean front r … - 

                                      Chesapeake Beach Resort$135

                                      Chesapeake Beach Resort$135
                                      Marina Del Mar Resort and Marina

                                      Marina Del Mar Resort and Marina

                                      527 Caribbean Drive, Key Largo
                                        2.5 out of 5.0
                                         
                                         
                                        3.6 out of 5 (1,869 reviews)
                                        Not all bad. Rooms are dated with dog hair on the floor. Pool is great and staff was friendly and helpful. Limit … - 

                                        Marina Del Mar Resort and Marina$125

                                        Marina Del Mar Resort and Marina$125
                                        Duval House

                                        Duval House

                                        815 Duval St, Key West
                                          3.0 out of 5.0
                                           
                                           
                                          4.5 out of 5 (55 reviews)
                                          duval house enjoyed our stay at the duval house. the staff was great, especially john. no complaints, save for … - 
                                          Map

                                          Recently booked Florida Keys hotels

                                          Banana Bay Resort and Marina
                                          2.5 out of 5.0
                                          Last booking: 25 minutes ago
                                          Drop Anchor Resort and Marina
                                          3.0 out of 5.0
                                          Last booking: 1 hour ago
                                          24 North Hotel Key West
                                          4.0 out of 5.0
                                          Last booking: 5 hours ago
                                          Fairfield Inn & Suites by Marriott Key West, Keys Collection
                                          3.0 out of 5.0
                                          Last booking: 6 hours ago
                                          Marina Del Mar Resort and Marina
                                          2.5 out of 5.0
                                          Last booking: 6 hours ago
                                          The Gates Hotel Key West
                                          4.0 out of 5.0
                                          Last booking: 7 hours ago
                                          Lighthouse Court Hotel - Key West
                                          3.5 out of 5.0
                                          Last booking: 7 hours ago
                                          The Reach, A Waldorf Astoria Resort
                                          4.0 out of 5.0
                                          Last booking: 8 hours ago
                                          DoubleTree Resort by Hilton Grand Key - Key West
                                          3.5 out of 5.0
                                          Last booking: 8 hours ago

                                          Independent Florida Keys Hotel Guide

                                          Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Florida Keys, Florida. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Florida Keys hotels guarantees an unparalleled level of comfort and quality.

                                          You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Florida Keys Independent locations may even offer extra little benefits and discounts for frequent travelers.