Central San Diego Vacations
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $1,045 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Where to stay in Central San Diego
Find the best Central San Diego areas and neighborhoods for the activities you enjoy most. Learn more about Central San Diego
Mission Valley
3 out of top 10 points of interest in this area
Boasting major shopping malls like Fashion Valley Mall and Westfield Mission Valley, this area offers entertainment and historic sites such as Mission San Diego de Alcalá and Presidio Park. Easily accessible via the San Diego Trolley system's Green Line.
Discover the most popular places to visit in Central San Diego
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
Balboa Park
Culture and nature converge in this diverse park located in the heart of the city.
Hotel Circle
Hotel Circle is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Check out the shops and top-notch restaurants in this family-friendly area.
What to do in Central San Diego
San Diego: Museum of Illusions Entry Ticket
$35
per adult
80% of travellers recommend
San Diego Whale Watching & Dolphin Cruise
$71
per adult
88% of travellers recommend
San Diego Old Town Trolley Hop-On Hop-Off Tour
$55
per adult
94% of travellers recommend
Central San Diego Hotel Deals
Days Inn by Wyndham San Diego Hotel Circle
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Mar 1 to Mar 2
$108 total
Mar 1 - Mar 2
Total with taxes and fees
8/10 Very Good! (2,503 reviews)
Great customer service and clean rooms, just a suspicious male in the area but security responded
Reviewed on Feb 24, 2026
Best Western Seven Seas
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Mar 1 to Mar 2
$84 total
Mar 1 - Mar 2
Total with taxes and fees
7.8/10 Good! (3,243 reviews)
Great space
Reviewed on Feb 24, 2026
Lafayette Hotel & Club
2223 El Cajon Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $263 total per night from Feb 26 to Feb 27
$263 total
Feb 26 - Feb 27
Total with taxes and fees
9.2/10 Wonderful! (1,491 reviews)
We had a great stay at the Lafayette Hotel. The highlight of our visit was the outstanding customer service from Brendon at the Gutter Bowling Alley. He was attentive, friendly, and went out of his way to help us get our drinks quickly. His professionalism and positive attitude really enhanced our ...
Reviewed on Feb 23, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Central San Diego Vacation Packages
Central San Diego Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | San Diego Intl. Airport (SAN) |
More vacations you might like
Explore a world of travel with Expedia
- San Diego County Hotels
- San Diego Hotels
- Hotels near Kearny Mesa
- Cheap Hotels in Kearny Mesa
- Motel 6 Hotels in Kearny Mesa
- Pet-Friendly Hotels in Kearny Mesa
- 5 Star Hotels in Kearny Mesa
- Marriott Hotels & Resorts in Kearny Mesa
- Extended Stay America Hotels in Kearny Mesa
- 3 Star Hotels in Kearny Mesa
- Hotels with Kitchenettes in Kearny Mesa
- Hotels with Restaurants in Kearny Mesa
- Resorts & Hotels with Spas in Kearny Mesa
- Hotels with Suites in Kearny Mesa
- Hotels with Free Parking in Kearny Mesa
- Extended Stay Hotels in Kearny Mesa
- Hotels with Balconies in Kearny Mesa
- Casino Hotels in Kearny Mesa
- Hotels with Free Breakfast in Kearny Mesa
- Beach Hotels in Kearny Mesa
- Romantic Hotels in Kearny Mesa
- Hotels with Hot Tubs in Kearny Mesa
- Hotel Wedding Venues Hotels in Kearny Mesa
- Destination Hotels in Kearny Mesa
- Hotels with Connecting Rooms in Kearny Mesa
- Hotels with Bars in Kearny Mesa
- 4 Star Hotels in Kearny Mesa
- Luxury Hotels in Kearny Mesa
- Hotels with Free Airport Shuttle in Kearny Mesa
- Business Hotels in Kearny Mesa
- Kimpton Hotels in Kearny Mesa
- Hyatt Hotels in Kearny Mesa
- Best Western Hotels in Kearny Mesa
- Hotels near Boomers San Diego
- Hotels near Marine Corps Air Station Miramar
- Hotels near Montgomery Field
- Flights to San Diego
- Flights from Montgomery Field
- Flights from Calexico (CXL) to San Diego (MYF)
- Flights from Dallas (DFW) to San Diego (MYF)
- Flights from Corvallis (CVO) to San Diego (MYF)
- Flights from Oceanside (OCN) to San Diego (MYF)
- Flights from Watsonville (WVI) to San Diego (MYF)
- Flights from San Jose (SJC) to San Diego (MYF)
- Flights from Detroit (DTW) to San Diego (MYF)
- Flights from Thermal (TRM) to San Diego (MYF)
- Flights from Salt Lake City (SLC) to San Diego (MYF)
- Flights from Chicago (ORD) to San Diego (MYF)
- Flights from Atlanta (ATL) to San Diego (MYF)
- Flights from San Carlos (SQL) to San Diego (MYF)
- Flights from Phoenix (PHX) to San Diego (MYF)
- Flights from San Francisco (SFO) to San Diego (MYF)
- Flights from New York (JFK) to San Diego (MYF)
- Flights from Portland (PDX) to San Diego (MYF)
- Flights from Boise (BOI) to San Diego (MYF)
- Flights from Oakland (OAK) to San Diego (MYF)
- Flights from Columbus (CMH) to San Diego (MYF)
- Flights from Raleigh (RDU) to San Diego (MYF)
- Flights from St. Louis (STL) to San Diego (MYF)
- Flights from Los Angeles (LAX) to San Diego (MYF)
- Flights from Auburn (AUN) to San Diego (MYF)
- Flights from Indianapolis (IND) to San Diego (MYF)
- Flights from Richland (RLD) to San Diego (MYF)
- Flights from Fort Meade (FME) to San Diego (MYF)
- Flights from Cottonwood (CTW) to San Diego (MYF)
- Flights from Denver (DEN) to San Diego (MYF)
- Flights from Cincinnati (CVG) to San Diego (MYF)
- Flights from Sacramento (SMF) to San Diego (MYF)
- Flights from Fort Myers (RSW) to San Diego (MYF)
- Flights from Las Vegas (LAS) to San Diego (MYF)
- Flights from Greenville (GSP) to San Diego (MYF)
- Flights from Mammoth Lakes (MMH) to San Diego (MYF)
- Flights from Salem (SLE) to San Diego (MYF)
- Flights from Xi'an (XIY) to San Diego (MYF)
- Flights from Bermuda Dunes (UDD) to San Diego (MYF)
- Flights from Santa Barbara (SBA) to San Diego (MYF)
- Flights from Hartford (BDL) to San Diego (MYF)
- Hopscotch Air Harrison (HRO) to San Diego (MYF) flights
- Flights from Ogden (OGD) to San Diego (MYF)
- Flights from Rifle (RIL) to San Diego (MYF)
- Flights from Eureka (EKA) to San Diego (MYF)
- Flights from Renton (RNT) to San Diego (MYF)
- Flights from Scottsdale (SCF) to San Diego (MYF)
- Flights from Washington (WAS) to San Diego (MYF)
- Flights from Hawthorne (HHR) to San Diego (MYF)
- Flights from Kansas City (MCI) to San Diego (MYF)
- Flights from Tulsa (TUL) to San Diego (MYF)
- Car rentals near San Diego
- Car rental San Diego Airport (SAN)
- Car rentals near Kearny Mesa
- Enterprise Rental Cars in Kearny Mesa
- Budget Rental Cars in Kearny Mesa
- Hertz Rental Cars in Kearny Mesa
- Sr Rent A Car Rental Cars in Kearny Mesa
- Avis Rental Cars in Kearny Mesa
- Car rentals near Marine Corps Air Station Miramar
- Car rental San Diego Airport (MYF)
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
