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La Mesa Vacation Rentals

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Check prices for these dates

In two weeks
Oct 2 - Oct 4
In two months
Nov 13 - Nov 15
In three months
Dec 11 - Dec 13
In four months
Jan 8 - Jan 10

Our top choices for La Mesa vacation rentals

TV

1. Mediterranean-inspired 1BR Guesthouse - Full Kitchen, Workspace & Garden

Mediterranean-inspired 1BR Guesthouse - Full Kitchen, Workspace & Garden
Mount Helix
10.0 out of 10, Exceptional, (1 review)
"We really enjoyed staying here. Clean and roomy and has everything you’d need. "
United States
Linda R.
$364 nightly
The price is $364
Sep 23 - Sep 24
Total with taxes and fees
Mediterranean-inspired 1BR Guesthouse - Full Kitchen, Workspace & Garden
Interior

2. King Bed, Big Yard, Prime Area, Ranch, 4BR/3Bth

King Bed, Big Yard, Prime Area, Ranch, 4BR/3Bth
La Mesa
$363 nightly
The price is $406
Sep 20 - Sep 21
Total with taxes and fees
King Bed, Big Yard, Prime Area, Ranch, 4BR/3Bth
Beach

3. Spacious King Bed Ranch Style, Prime Area, 4BR/2BTH

Spacious King Bed Ranch Style, Prime Area, 4BR/2BTH
La Mesa
9.0 out of 10, Wonderful, (2 reviews)
$365 nightly
The price is $398
Sep 27 - Sep 28
Total with taxes and fees
Spacious King Bed Ranch Style, Prime Area, 4BR/2BTH
Interior

4. Ranch-Style w Gated Yard, 4 Parking, 4 Bedroom 3 Bathroom

Ranch-Style w Gated Yard, 4 Parking, 4 Bedroom 3 Bathroom
La Mesa
10.0 out of 10, Exceptional, (1 review)
$383 nightly
The price is $383
Sep 20 - Sep 21
Total with taxes and fees
Ranch-Style w Gated Yard, 4 Parking, 4 Bedroom 3 Bathroom
Exterior

5. Gated Yard, King Bed, Parking, Ranch-Style La Mesa

Gated Yard, King Bed, Parking, Ranch-Style La Mesa
La Mesa
$394 nightly
The price is $429
Sep 20 - Sep 21
Total with taxes and fees
Gated Yard, King Bed, Parking, Ranch-Style La Mesa
Coffee/tea maker, fridge, microwave, oven

6. Modern SD Escape: SDSU/Downtown <10 Min, GameRoom, Fire Pit, Easy Freeway Access

Modern SD Escape: SDSU/Downtown <10 Min, GameRoom, Fire Pit, Easy Freeway Access
La Mesa
9.0 out of 10, Wonderful, (10 reviews)
"We had a wonderful stay! The home is lovely, clean and exactly as described. Jonathan is very nice and easy to communicate with. We loved staying here to celebrate our son’s graduation from SDSU!"
United States
Anonymous traveler
$504 nightly
The price is $504
Sep 30 - Oct 1
Total with taxes and fees
Modern SD Escape: SDSU/Downtown <10 Min, GameRoom, Fire Pit, Easy Freeway Access
Interior

7. Cozy Mid-Century Charmer - Huge Backyard - Firepit

Cozy Mid-Century Charmer - Huge Backyard - Firepit
La Mesa
9.8 out of 10, Exceptional, (12 reviews)
"Clean and great host"
United States
Michelle D.
$753 nightly
The price is $753
Oct 7 - Oct 8
Total with taxes and fees
Cozy Mid-Century Charmer - Huge Backyard - Firepit
1 bedroom, WiFi (free), bed sheets

8. Splendid 1-bedroom apartment in delightful La Mesa with AC and Laundry

Splendid 1-bedroom apartment in delightful La Mesa with AC and Laundry
Mid-City
10.0 out of 10, Exceptional, (7 reviews)
"This is probably the nicest place in which I have stayed in my thirty or so years of traveling to San Diego. And Rico was a superb host. But I didn’t have to ask him for much, as he provided an abundance of sundries and drinks. Highest recommendation."
United States
Peter
$147 nightly
The price is $147
Sep 29 - Sep 30
Total with taxes and fees
Splendid 1-bedroom apartment in delightful La Mesa with AC and Laundry
Private kitchen

9. Lake Murray 3BR Retreat with AC and Skylight

Lake Murray 3BR Retreat with AC and Skylight
La Mesa
10.0 out of 10, Exceptional, (16 reviews)
"Our stay was fantastic and it had everything we need for our 1 week stay. I recommend this location. "
United States
Rosa C.
$289 nightly
The price is $289
Sep 23 - Sep 24
Total with taxes and fees
Lake Murray 3BR Retreat with AC and Skylight
1 bedroom, iron/ironing board, WiFi, bed sheets

10. Cozy Private Studio in El Cajon

Cozy Private Studio in El Cajon
Mount Helix
8.8 out of 10, Excellent, (29 reviews)
"It was a great plead to stay"
United States
Simon
$137 nightly
The price is $137
Sep 27 - Sep 28
Total with taxes and fees
Cozy Private Studio in El Cajon
Dining

11. La Mesa Family Retreat - 20 minutes to Beaches & More!

La Mesa Family Retreat - 20 minutes to Beaches & More!
La Mesa
9.0 out of 10, Wonderful, (11 reviews)
"The property was well located for us. "
United States
Ann D.
$536 nightly
The price is $536
Sep 22 - Sep 23
Total with taxes and fees
La Mesa Family Retreat - 20 minutes to Beaches & More!
Smart TV

12. 'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!

'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!
Encanto
8.8 out of 10, Excellent, (40 reviews)
"Beds were very comfortable."
United States
Paula
$213 nightly
The price is $238
Sep 21 - Sep 22
Total with taxes and fees
'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!
Property grounds

13. La Casita Guest House, private fenced yard & with heat and AC, pet friendly

La Casita Guest House, private fenced yard & with heat and AC, pet friendly
Mount Helix
9.8 out of 10, Exceptional, (13 reviews)
"Thank you so much for the hospitality and your kindness"
United States
Lisa D.
$287 nightly
The price is $295
Sep 20 - Sep 21
Total with taxes and fees
La Casita Guest House, private fenced yard & with heat and AC, pet friendly
Interior

14. Canyon View Tranquil Oasis, Private Pool and Dreamy Sunsets, New Backyard

Canyon View Tranquil Oasis, Private Pool and Dreamy Sunsets, New Backyard
San Carlos
9.4 out of 10, Exceptional, (70 reviews)
"Communication with the host was excellent. Very nice home with a beautiful pool. Would visit again"
United States
Mary N.
$574 nightly
The price is $641
Sep 23 - Sep 24
Total with taxes and fees
Canyon View Tranquil Oasis, Private Pool and Dreamy Sunsets, New Backyard
Terrace/patio

15. Cozy 2-Bedroom Cottage Near Balboa Park

Cozy 2-Bedroom Cottage Near Balboa Park
Mid-City
8.8 out of 10, Excellent, (12 reviews)
"Overall it was a great place to stay."
United States
Cristal M.
$255 nightly
The price is $284
Sep 20 - Sep 21
Total with taxes and fees
Cozy 2-Bedroom Cottage Near Balboa Park
Lobby

16. Little Italy Inn - Limited Service Apart Hotel

Little Italy Inn - Limited Service Apart Hotel
2.5 star property
Downtown San Diego
8.2 out of 10, Very good, (303 reviews)
"Very close to little Italy with tons of good food."
United States
Laura
$103 nightly
The price is $119
Oct 6 - Oct 7
Total with taxes and fees
Little Italy Inn - Limited Service Apart Hotel
Lobby sitting area

17. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (466 reviews)
"It's good hotel for small day 1 to 3 nights no more then that due to the size of the room."
Canada
patrick
$101 nightly
The price is $114
Sep 28 - Sep 29
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
Exterior

18. Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1,209 reviews)
"Great for traveling families."
United States
Veronica Dangerfield
$169 nightly
The price is $196
Sep 29 - Sep 30
Total with taxes and fees
Marriott Vacation Club®, San Diego
Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio

19. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (206 reviews)
"Receptionist was super nice and super helpful. The location was perfect. Everything was super close. Loved the room."
United States
Victor
$157 nightly
The price is $177
Sep 30 - Oct 1
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
Interior

20. 3bd with TV and AC, 2 air mattress, 2ba, 15-20 minute to everything in San Diego

3bd with TV and AC, 2 air mattress, 2ba, 15-20 minute to everything in San Diego
Mount Hope
10.0 out of 10, Exceptional, (28 reviews)
"Yes and very close to all the things we wanted to do, extremely clean and extremely well maintained and extras that were nice like bottles of water"
United States
Brent H.
$309 nightly
The price is $345
Sep 21 - Sep 22
Total with taxes and fees
3bd with TV and AC, 2 air mattress, 2ba, 15-20 minute to everything in San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top La Mesa Hotel Reviews

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

10/10 Excellent
"Easy check in/out. Pleasant staff. Buffet breakfast just okay. More options should be offered."
Liza 1-night trip
Posted 10 hours ago
Marriott Marquis San Diego Marina

Find out more about La Mesa

Everything you need to know about La Mesa vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the La Mesa vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect La Mesa vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

La Mesa vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in La Mesa. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit La Mesa in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $114 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on La Mesa rentals

At Expedia, we put the best La Mesa vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top La Mesa rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream La Mesa vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around La Mesa. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Are there vacation rentals in La Mesa?

Yes, you can find vacation rentals in La Mesa near La Mesa Memorial Fine Arts Center, or you can choose a secluded option if you'd like a relaxing place to stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

What are some of the best vacation rentals that La Mesa has to offer?

Luxurious Estate Home-Sumptuous Views - Resort Like!!!: This La Mesa vacation home rental offers a balcony, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a hot tub.

How many vacation rentals are there in La Mesa?

With 63 Expedia vacation rentals, you're sure to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

While exploring the area, visit family-friendly sights like San Diego Zoo, or get outside and enjoy nature at Mission Bay. While in the area, you can also visit popular places like Petco Park and Port of San Diego.

What are vacation rentals like in La Mesa?

Vacation rentals are privately owned properties you can book for several days or more in La Mesa. Vacation rentals feature amenities such as WiFi and washers and dryers so you'll have everything you need. If you're concerned about a clean environment, vacation rentals can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great choice for families.