Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured La Mesa Resorts & Hotels with Spas

See all 1,350 Hotels in La Mesa
Heritage Inn La Mesa

Heritage Inn La Mesa

7851 Fletcher Pkwy, La Mesa
2.5 out of 5.0
2.7 out of 5 (866 reviews)
Close to my workIt was very uncomfortable we had to listen to the next room fighting baby must of been crying for 25 min or more we got to the poor we call the front desk
  Jan 11, 2018

$47

$47
Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego

9550 Murray Dr, La Mesa
3.0 out of 5.0
4.1 out of 5 (603 reviews)
Perfect PlaceGreat location, very clean, super friendly staff were who very helpful, good breakfast
  Jan 16, 2018

$87

$87
Days Inn & Suites San Diego - SDSU

Days Inn & Suites San Diego - SDSU

7475 El Cajon Blvd, La Mesa
2.5 out of 5.0
3.0 out of 5 (859 reviews)
Nice, close to family.The only drawback is the $150 deposit they hold for several days.
  Jan 19, 2018

$51

$51
Map

Recently booked Resorts & Hotels with Spas in La Mesa

Lodge of La Mesa (A Quiet Hotel For Adults Only)
2.5 out of 5.0
Last booking: 55 minutes ago
Heritage Inn La Mesa
2.5 out of 5.0
Last booking: 3 hours ago
Days Inn & Suites San Diego - SDSU
2.5 out of 5.0
Last booking: 5 hours ago
Best Western Plus La Mesa San Diego
3.0 out of 5.0
Last booking: 12 hours ago
Holiday Inn La Mesa
3.5 out of 5.0
Last booking: 18 hours ago

La Mesa Resorts & Spa Travel Guide

Indulge Yourself with a La Mesa Spa Vacation

Grab your luggage and leave behind concerns to go on your tension-free time-off. Looking for an extravagant spa hotel that rolls out the red carpet? We have what you are looking for. Desire to stay in a soothing secluded spa hotel? No worries. In fact, this area is so popular that it saw a big increase of visitors that are making it their go-to spot to unwind. If your optimal spa vacation is to get relief from the bustle , then you'll find more travelers are finding out that this town is the ideal retreat to do little and love every moment.

We Have Divine Spa Deals in La Mesa

There is no need to worry about securing a great hotel. La Mesa has tons of options to appease most any preference or budget. You'll soon find that the a number of these hotels eclipse expectations and that the staff takes pride in keeping your room and the facilities spotless. After you've indulged yourself by getting a massage, unwinding in the steam room, or lounging by the pool, spend your evening getting even more relaxed as you take pleasure in the small-town vibe of this quaint city. You'll have no troubles staying at ease in this area which prides itself on their laid-back take on life. Once you step out for an evening stroll, you can spend a relaxed evening taking in this charming city's casual vibe. Regardless of what you decide to do, just be sure to take it easy. Your spa trip should be nothing but exceptionally relaxing.

Providing plenty of comfortable retreats and and calm surroundings, it's clear why an increasing number of people are choosing La Mesa as their stress-free spa holiday sanctuary.