La Mesa Vacations from $472

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Your La Mesa Vacation

Lock in a La Mesa vacation package that includes everything you need and nothing you don't. Good for gift and craft shops, dining and nightlife, think about staying in the neighborhood of Downtown San Diego. The Magnolia, Santee Lakes and Grossmont College are just a few of the attractions you'll want to explore during your trip to La Mesa. Browse Expedia's wide range of travel options and start organizing your perfect vacation to La Mesa today.

The Latest La Mesa vacation packages

Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
Price was $876, price is now $472 per person
$472
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to San Diego (SAN)
8.4/10 Very Good! (1,543 reviews)
I stayed at The Sofia Hotel in downtown San Diego and loved its mix of historic charm and modern comfort. The location is excellent—just steps from the Gaslamp Quarter, the waterfront, and conveniently close to the Santa Fe train station, making travel super easy.

Reviewed on Aug 28, 2025

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Price was $1,723, price is now $876 per person
$876
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to San Diego (SAN)
9/10 Wonderful! (993 reviews)
You get wristbands for your hotel keys

Reviewed on Aug 28, 2025

La Jolla Cove Suites

La Jolla Cove Suites

3 out of 5
Village of La Jolla
Save 100% on your flight
Price was $1,039, price is now $576 per person
$576
per person
Nov 1 - Nov 6
found 2 hours ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
7/10 Good! (1,023 reviews)
I enjoyed the quietness of the terrace room and how close the shopping area and park are. Great location, simple check in, would love to visit again

Reviewed on Aug 26, 2025

Sand Castle Inn

Sand Castle Inn

2.5 out of 5
Save 100% on your flight
Price was $1,127, price is now $676 per person
$676
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to San Diego (SAN)
8.2/10 Very Good! (477 reviews)
Wasn't looking for anything fancy; this was just right. And right across the street from the beach!

Reviewed on Jul 21, 2025

The Wayfarer San Diego

The Wayfarer San Diego

4 out of 5
Mission Beach
Save 100% on your flight
Price was $1,598, price is now $971 per person
$971
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to San Diego (SAN)
9.4/10 Exceptional! (1,579 reviews)
Property was well kept and clean. Pool and hot tub were convenient. Location is awesome.

Reviewed on Aug 28, 2025

Don't see what you're looking for?
See all available trips from Columbus to La Mesa
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Discover the most popular places to visit in La Mesa

Mount Helix Park

Learn about the local history of Casa de Oro-Mount Helix when you spend time at Mount Helix Park. Amble around this family-friendly area's waterfront or attend a sporting event.

Mount Helix Park

Computer Museum of America

You can spend an afternoon studying the exhibits at Computer Museum of America during your trip to La Mesa. Attend a sporting event while in this walkable area or simply enjoy the top-notch restaurants.

Computer Museum of America

What to do in La Mesa

San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

$124
per adult
88% of travellers recommend
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
Coronado: San Diego Bay Jetski Rental

Coronado: San Diego Bay Jetski Rental

$225
per traveler
100% of travellers recommend
Coronado: San Diego Bay Jetski Rental
Haunted San Diego: The Only Ghost Tour with Exclusive Entry

Haunted San Diego: The Only Ghost Tour with Exclusive Entry

$58
per adult
80% of travellers recommend
Haunted San Diego: The Only Ghost Tour with Exclusive Entry
See all activities in La Mesa

La Mesa Hotel Deals

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Sep 16 to Sep 17
$128 total
Sep 16 - Sep 17
Total with taxes and fees
8/10 Very Good! (1,998 reviews)
"Good location staff great pooland bar"

Reviewed on Aug 25, 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $201 total per night from Sep 1 to Sep 2
$201 total
Sep 1 - Sep 2
Total with taxes and fees
Wyndham San Diego Bayside
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
$165 nightly
The price is $190 total per night from Sep 3 to Sep 4
$190 total
Sep 3 - Sep 4
Total with taxes and fees
9/10 Wonderful! (2,838 reviews)
"A great property that is well taken care of. The staff care about the customers and the location is beautiful. It is a small hotel near the water, away from the crazy traffic, bustle of downtown, noise. We have stayed here 3 times already and will definitely stay again. A great value for the ..."

Reviewed on Aug 25, 2025

Bay Club Hotel & Marina
See all 8,156 properties in La Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a La Mesa vacation package cost?
Offering great value package deals from $472 on Expedia, you'll be pleasantly surprised at how much a vacation to La Mesa costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to La Mesa?
January, October and December are the best times to search for cheap La Mesa vacation packages. Opting to travel in quieter months means you can typically find lower prices on flights and hotels.
How many days is enough for La Mesa?
Usually, a handful of days is enough to visit the major attractions during your La Mesa vacation. However, if you prefer to have some time to chill out or go on day trips, think about extending your trip.
Is it worth booking a vacation package to La Mesa?
It's no wonder a La Mesa vacation is on the to-do list of many travelers. Well-known attractions like Mount Helix Park are just the beginning of things to keep you busy here.
How to find the best La Mesa package deals?
Use Expedia's filters to help you find some fabulous La Mesa package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your adventure for midweek, or look for La Mesa package deals in the low season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a La Mesa vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your flight, hotel and car rental into one great-value price and enjoy significant savings. You'll usually score a better deal than booking each component individually. And you'll still get the freedom to create a personalized La Mesa vacation by choosing your favorite type of stay, airline and car class.
When to book a vacation package to La Mesa?
Secure fantastic discounts by reserving your flights in advance with Expedia. If being spontaneous is more your style, take advantage of our last-minute deals for an impromptu La Mesa adventure.
How to plan a trip to La Mesa?

  1. Pick your travel dates: What you plan to do in La Mesa and your favorite season will help you decide when to get away.
  2. Set your budget: Factor in expenses like food, flights and transportation when calculating how much to set aside for your trip to La Mesa. Then, choose a property that matches your budget, whether that's a low-cost stay or a more upscale getaway.
  3. Discover La Mesa using Expedia's trip planning tool: Gain insights into the most popular attractions and best properties for your trip to La Mesa. You can also save your must-visit places, collaborate with family and friends and organize all your plans in one place.
  4. Work out your trip length: Consider how long you'd like to spend exploring La Mesa. Plan your days so you can get to all the activities and attractions you're interested in without rushing.
  5. Bundle your accommodations and airfare: Once you've nailed down your trip dates and duration, book the right La Mesa vacation package for you.
  6. Book activities and experiences ahead of time: Whether it's entrance to a major attraction or a day trip in nature, you won't have to worry about missing out on the best La Mesa has to offer. Find all the incredible things to do in La Mesa with our dedicated activity guide.

Does Expedia offer Book Now, Pay Later La Mesa vacation packages?
If you're like us, you love going away but don't love the big price tag that can sometimes come with it. That's why we've created Book Now, Pay Later vacations. With the help of online lender Affirm, you can break down the total cost of your La Mesa vacation over 3, 6 or 12 months. There are also no hidden costs or late payment fees, so you can secure great vacation packages with payment plans as soon as you see them.

Explore a world of travel with Expedia

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.