Book Lake City Bed & Breakfast

Start date: Check-in selected.
To Date
End date: Check-out

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

Next weekend
Dec 19 - Dec 21
In two weeks
Dec 26 - Dec 28
In one month
Jan 9 - Jan 11
In two months
Feb 6 - Feb 8
No exact matches found, but these alternatives could be just right

Recommended hotels in Lake City

Exterior
The Inn at the Crossroads

The Inn at the Crossroads

The Inn at the Crossroads
2.0 star property
Lake City
9.4 out of 10, Exceptional, (828)
"Awesome hotel stay "
United States
Jerry
$133 nightly
The price is $150
Dec 23 - Dec 24
Total with taxes and fees
The Inn at the Crossroads
Lobby
Quality Inn & Suites Lake City

Quality Inn & Suites Lake City

Quality Inn & Suites Lake City
2.5 star property
Lake City
7.0 out of 10, Good, (165)
"Good for the weekend. "
United States
Amber
$96 nightly
The price is $107
Jan 4 - Jan 5, 2026
Total with taxes and fees
Quality Inn & Suites Lake City
In-room safe, desk, laptop workspace, blackout drapes
Security inn & suites

Security inn & suites

Security inn & suites
2.0 star property
Lake City
$120 nightly
The price is $134
Jan 1 - Jan 2, 2026
Total with taxes and fees
Security inn & suites
Lobby
Days Inn by Wyndham Lake City

Days Inn by Wyndham Lake City

Days Inn by Wyndham Lake City
2.0 star property
Lake City
6.4 out of 10, (241)
"Overall good stay for 1 night. "
United States
April
$98 nightly
The price is $109
Jan 1 - Jan 2, 2026
Total with taxes and fees
Days Inn by Wyndham Lake City
Exterior
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area
2.5 star property
Florence
9.2 out of 10, Wonderful, (1162)
"Enjoyed our stay there. "
United States
Cathy
$100 nightly
The price is $112
Dec 14 - Dec 15
Total with taxes and fees
Comfort Inn & Suites Florence Center Area
Check-in/check-out kiosk
Florence Inn and Suites

Florence Inn and Suites

Florence Inn and Suites
2.5 star property
Florence
6.4 out of 10, (324)
"We had a good experience here. Staff very helpful "
United States
Susie
$55 nightly
The price is $62
Dec 14 - Dec 15
Total with taxes and fees
Florence Inn and Suites
Restaurant
Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center
2.5 star property
Florence
9.0 out of 10, Wonderful, (814)
"Very friendly and responsive staff. Very clean and comfortable room. Would definitely stay there again when we pass this way. "
United States
Maggie
$95 nightly
The price is $107
Dec 21 - Dec 22
Total with taxes and fees
Hampton Inn & Suites Florence Center
Cotton Room | Memory foam beds, individually decorated, individually furnished
Bella's Boutique Hotel

Bella's Boutique Hotel

Bella's Boutique Hotel
2.0 star property
Hemingway
6.0 out of 10, (12)
"Quaint and cozy, convenient for visiting family. The staff and owner were very welcoming and generous. "
United States
James
$90 nightly
The price is $99
Dec 13 - Dec 14
Total with taxes and fees
Bella's Boutique Hotel
Lobby
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center
2.5 star property
Florence
7.8 out of 10, Good, (1254)
"Room was spotless, bed extremely comfortable and staff was very helpful and courteous. Would DEFINITELY stay there again. "
United States
Tim
$79 nightly
The price is $88
Jan 12 - Jan 13, 2026
Total with taxes and fees
Quality Inn & Suites Florence Civic Center
Exterior
Affordable Suites Florence

Affordable Suites Florence

Affordable Suites Florence
2.5 star property
Florence
9.2 out of 10, Wonderful, (122)
"Was clean and the staff is friendly."
United States
Marilyn
$64 nightly
The price is $72
Dec 17 - Dec 18
Total with taxes and fees
Affordable Suites Florence
Studio, Multiple Beds | Premium bedding, pillowtop beds, desk, blackout drapes
TownePlace Suites by Marriott Florence

TownePlace Suites by Marriott Florence

TownePlace Suites by Marriott Florence
3.0 star property
Florence
9.0 out of 10, Wonderful, (701)
"Good stay, great staff"
United States
James
$99 nightly
The price is $111
Dec 14 - Dec 15
Total with taxes and fees
TownePlace Suites by Marriott Florence
Desk, iron/ironing board, free WiFi, bed sheets
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center
2.5 star property
Florence
6.8 out of 10, (1002)
"Clean rooms and wonderful staff "
United States
Rita
$62 nightly
The price is $69
Dec 14 - Dec 15
Total with taxes and fees
Days Inn by Wyndham Florence Near Civic Center
View from property
Fairfield Inn & Suites by Marriott Florence I-20

Fairfield Inn & Suites by Marriott Florence I-20

Fairfield Inn & Suites by Marriott Florence I-20
2.5 star property
Florence
9.0 out of 10, Wonderful, (548)
"Good breakfast and room service "
United States
Indira
$103 nightly
The price is $116
Dec 21 - Dec 22
Total with taxes and fees
Fairfield Inn & Suites by Marriott Florence I-20
Lobby
Residence Inn Marriott Florence

Residence Inn Marriott Florence

Residence Inn Marriott Florence
3.0 star property
Florence
8.8 out of 10, Excellent, (471)
"Clean rooms and nice size suite area. "
United States
Yolanda
$95 nightly
The price is $107
Dec 25 - Dec 26
Total with taxes and fees
Residence Inn Marriott Florence
Interior
Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.
Florence
9.8 out of 10, Exceptional, (42)
"The house was beautiful. We would stay there again!!"
United States
Stephanie L.
$208 nightly
The price is $233
Dec 14 - Dec 15
Total with taxes and fees
Walking distance from one of South Carolina's top Medical centers.
Indoor pool
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
2.5 star property
Florence
9.2 out of 10, Wonderful, (1001)
"Very good breakfast & convenient location"
United States
Diedre
$110 nightly
The price is $123
Dec 14 - Dec 15
Total with taxes and fees
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
Lobby
Quality Inn Kingstree North

Quality Inn Kingstree North

Quality Inn Kingstree North
2.5 star property
Kingstree
6.0 out of 10, (171)
"There were no light bulbs in the room lamps, and we started seeing roaches."
United States
John
$66 nightly
The price is $73
Jan 5 - Jan 6, 2026
Total with taxes and fees
Quality Inn Kingstree North
Exterior
Aloft Florence

Aloft Florence

Aloft Florence
3.0 star property
Florence
8.6 out of 10, Excellent, (247)
"You have to try the apple muffin. It’s so delicious my whole family had to try it. "
United States
Tyler
$101 nightly
The price is $113
Dec 16 - Dec 17
Total with taxes and fees
Aloft Florence
Terrace/patio
Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC
3.0 star property
Florence
8.2 out of 10, Very Good, (1000)
"Clean room, good location, quick checkin"
United States
Brian
$103 nightly
The price is $116
Dec 23 - Dec 24
Total with taxes and fees
Home2 Suites by Hilton Florence, SC
1 bedroom, iron/ironing board, WiFi, bed sheets
Charming 1-bedroom cabin in welcoming Florence with AC and heating

Charming 1-bedroom cabin in welcoming Florence with AC and heating

Charming 1-bedroom cabin in welcoming Florence with AC and heating
2.0 star property
Florence
Charming 1-bedroom cabin in welcoming Florence with AC and heating
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Lake City Hotel Reviews

Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

10/10 Excellent
"Friendly staff and great breakfast"
Jo 1-night trip
Posted 3 days ago
Hampton Inn & Suites Florence Center

Find out more about Lake City

Lake City B&B information

Number of reviews
10,097
Accommodation
0 B&B
Lowest Price
$62
Highest Price
$233

Frequently asked questions

Searching for B&Bs in Lake City?
Whether you're traveling with your family and want a friendly place to stay, or you're a solo traveler hoping to meet fellow tourists, B&Bs can be a great choice for many types of vacationers. While you're here, you can get to know Lake City by exploring its natural beauty. Consider a stop by Lions Park and Ronald E. McNair Life History Center.
Are you thinking about B&Bs over traditional hotel rooms?
With attentive service, opportunities to mingle with other guests, and tasty breakfasts, B&Bs provide a truly one-of-a-kind setting.
What are the top B&Bs in Lake City?
You might be interested in one of these choices if you're looking for an accommodation where breakfast is included with your stay: The Inn at the CrossroadsQuality Inn & Suites Lake CityDays Inn by Wyndham Lake City
When should I book my B&B in Lake City?
When you're dreaming of a trip to Lake City, be sure to take into account the year-round temperatures. The hottest months are usually July and August with an average temp of 78°F, while the coldest months are January and February with an average of 51°F. Average annual precipitation for Lake City is 53 inches.
What is there to do in Lake City?
Travelers enjoy Lake City for its lakeside setting and restaurants. When you want to spend some time in the great outdoors, Lions Park and Ronald E. McNair Life History Center are some notable spots. You might put The Country Club at Lake City and Lynches Lake Historical Society on your list if you want to see more of the area.
How can I get to and around Lake City?
You can plan your excursions in and around Lake City ahead of time with these transportation options. Fly into Florence, SC (FLO-Florence Regional), which is located 22.2 mi (35.8 km) from the heart of the city. If you'd like to venture out around the area, you may want a rental car for your journey.

Explore a world of travel with Expedia