Mayo River Vacations from $380

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The Latest Mayo River vacation packages

Price found within the past 48 hours. Click for updated prices.
Atrium Inn

Atrium Inn

2 out of 5
Price was $421, price is now $380 per person
$380
per person
Apr 18 - Apr 21
found 3 hours ago
Roundtrip flight included
New York (NYC) to Greensboro (GSO)
8.2/10 Very Good! (359 reviews)
Decor was wonderful. Very clean. Should think about serving a continental breakfast

Reviewed on Sep 21, 2025

O.Henry Hotel

O.Henry Hotel

4 out of 5
Price was $794, price is now $624 per person
$624
per person
Apr 18 - Apr 21
found 3 hours ago
Roundtrip flight included
New York (NYC) to Greensboro (GSO)
9.8/10 Exceptional! (724 reviews)
The room was beautifully appointed and perfectly clean. It was absolutely quiet, allowing us a wonderful night's sleep. The staff was friendly and helpful.

Reviewed on Feb 11, 2026

Comfort Suites Greensboro - High Point

Comfort Suites Greensboro - High Point

2.5 out of 5
Price was $485, price is now $409 per person
$409
per person
Apr 18 - Apr 21
found 3 hours ago
Roundtrip flight included
New York (NYC) to Greensboro (GSO)
8.8/10 Excellent! (653 reviews)
Hotel smelled amazing. Shower walls weren’t clean. They had shampoo or conditioner still on the wall. The blue color matched the hotel supplied product. The mirror was also smeared and dirty. Doors slam in the hallway constantly also

Reviewed on Feb 9, 2026

Holiday Inn Express Hotel & Suites Greensboro Airport Area by IHG

Holiday Inn Express Hotel & Suites Greensboro Airport Area by IHG

2.5 out of 5
Price was $483, price is now $431 per person
$431
per person
Apr 18 - Apr 21
found 3 hours ago
Roundtrip flight included
New York (NYC) to Greensboro (GSO)
8.8/10 Excellent! (709 reviews)
GREAT BREAKFAST /FRIENDLY STAFF

Reviewed on Jan 11, 2026

Holiday Inn Express & Suites Greensboro-(I-40 Wendover) by IHG

Holiday Inn Express & Suites Greensboro-(I-40 Wendover) by IHG

2.5 out of 5
Price was $462, price is now $413 per person
$413
per person
Apr 18 - Apr 21
found 3 hours ago
Roundtrip flight included
New York (NYC) to Greensboro (GSO)
8.8/10 Excellent! (852 reviews)
Great staff and breakfast, very clean

Reviewed on Feb 13, 2026

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Discover the most popular places to visit in Mayo River

The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.

Reynolds Homestead

You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas.

Reynolds Homestead

Mayo River Hotel Deals

The Lodge at Primland, Auberge Collection

The Lodge at Primland, Auberge Collection

5 out of 5
2000 Busted Rock Rd Meadows Of Dan VA
$401 nightly
The price is $450 total per night from Mar 18 to Mar 19
$450 total
Mar 18 - Mar 19
Total with taxes and fees
9/10 Wonderful! (26 reviews)
The resort is an experience. The staff were helpful and genuine.

Reviewed on Nov 9, 2025

The Lodge at Primland, Auberge Collection
Hampton Inn Eden

Hampton Inn Eden

2.5 out of 5
724 S Van Buren Rd Eden NC
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $128 total per night from Feb 27 to Feb 28
$128 total
Feb 27 - Feb 28
Total with taxes and fees
8.6/10 Excellent! (440 reviews)
The room and the eating area were both very clean. The staff is nice and the breakfast was good.

Reviewed on Jan 21, 2026

Hampton Inn Eden
Hotel Floyd

Hotel Floyd

2 out of 5
300 Rick Lewis Way Floyd VA
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Feb 17 to Feb 18
$121 total
Feb 17 - Feb 18
Total with taxes and fees
9.6/10 Exceptional! (494 reviews)
Room was very nice! We had a wonderful Valentine stay ♥️. We have stayed one other time and has not disappointed. The continental breakfast is wonderful. We will stay again!

Reviewed on Feb 15, 2026

Hotel Floyd
See all 269 properties in Mayo River
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mayo River Vacation Packages

Mayo River Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Piedmont Triad Intl. Airport (GSO)

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Frequently asked questions

How much does a Mayo River vacation package cost?
You'll find cheap prices from $380 on Expedia for your Mayo River getaway. However, a range of factors like the season, choice of hotel and length of stay will determine how much your vacation to Mayo River costs.
What are the cheapest months to go to Mayo River?
March, August and December are the best times to look for cheap Mayo River vacation packages. Choosing to travel in quieter periods means you'll typically find lower prices on flights and hotels.
How many days is enough for Mayo River?
Typically, a handful of days is enough to explore the top sights during your Mayo River vacation. However, if you prefer to have more time to chill out or go on day tours, consider extending your itinerary.
How to find the best Mayo River package deals?
Bagging a cheap Mayo River package deal is easy with Expedia. After you've entered your destination and trip dates under our "Packages" tab, set your maximum budget, add some filters and see what's available. You can personalize your search by "Amenities," "Property type," "Popular locations" and more. Order the results by "Price: low to high" to discover the most wallet-friendly Mayo River package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Mayo River vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll generally land a better deal than booking each component separately. And you'll still get the freedom to create a customized Mayo River vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Mayo River?
Secure incredible bargains by reserving your flights ahead of time with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment Mayo River adventure.
How to plan a trip to Mayo River?

  1. Choose when to travel: Check your schedule and pack your bags. Your favorite time of year and the type of activities available will also help you decide when to visit Mayo River.
  2. Calculate your budget: Ensure you have enough money to cover everything from transportation and meals to experiences and flights. Your accommodations will likely be the biggest expense during your trip to Mayo River.
  3. Use our trip planning tool to discover Mayo River: Research every part of your trip to Mayo River with this handy planner. Invite your family and friends to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Set the duration of your trip: Start by listing all the attractions you'd like to experience in Mayo River. Then, estimate how long you'll need at each, as well as any travel time.
  5. Bundle your bookings: With your travel dates in order, you can combine your hotels, car rental, flights and more into a customized Mayo River vacation package.
  6. Add on excursions and experiences: Have a look at our dedicated travel guide to find some exciting things to do in Mayo River. Book tickets or make reservations as soon as you can to save time and skip the hassle of looking for activities once you arrive.

Does Expedia offer Book Now, Pay Later Mayo River vacation packages?
Set off on your dream escape to Mayo River with our Book Now, Pay Later vacations. No need to save like crazy or wait until the next payday — we've teamed up with online lender Affirm to give you more financial flexibility. Our vacation packages with payment plans allow you to spread the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, you can easily stay on budget and snap up travel deals while they last.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.