Mayo River Vacations from $460

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Mayo River vacation packages

Price found within the past 48 hours. Click for updated prices.
Comfort Inn Greensboro - Kernersville

Comfort Inn Greensboro - Kernersville

2.5 out of 5
Price was $565, price is now $460 per person
$460
per person
Apr 8 - Apr 13
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
8.4/10 Very Good! (1,001 reviews)
People smoking weed nearlbt

Reviewed on Nov 7, 2025

Proximity Hotel

Proximity Hotel

4 out of 5
Save 100% on your flight
Price was $1,049, price is now $833 per person
$833
per person
Apr 8 - Apr 13
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
9.6/10 Exceptional! (879 reviews)
Great! I will be back.

Reviewed on Feb 10, 2026

Hyatt Place Greensboro

Hyatt Place Greensboro

3 out of 5
Price was $706, price is now $564 per person
$564
per person
Apr 8 - Apr 13
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
7.8/10 Good! (1,001 reviews)
Great staff and room

Reviewed on Jan 1, 2026

Comfort Suites Greensboro - High Point

Comfort Suites Greensboro - High Point

2.5 out of 5
Price was $676, price is now $549 per person
$549
per person
Apr 8 - Apr 13
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
8.8/10 Excellent! (653 reviews)
Hotel smelled amazing. Shower walls weren’t clean. They had shampoo or conditioner still on the wall. The blue color matched the hotel supplied product. The mirror was also smeared and dirty. Doors slam in the hallway constantly also

Reviewed on Feb 9, 2026

Fairfield Inn & Suites by Marriott Greensboro Wendover

Fairfield Inn & Suites by Marriott Greensboro Wendover

2.5 out of 5
Price was $675, price is now $549 per person
$549
per person
Apr 8 - Apr 13
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
9/10 Wonderful! (707 reviews)
Everything was good and upst

Reviewed on Jan 20, 2026

Don't see what you're looking for?
See all available trips from Columbus to Mayo River
View all trips

Discover the most popular places to visit in Mayo River

The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.

Reynolds Homestead

You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas.

Reynolds Homestead

Mayo River Hotel Deals

The Lodge at Primland, Auberge Collection

The Lodge at Primland, Auberge Collection

5 out of 5
2000 Busted Rock Rd Meadows Of Dan VA
$401 nightly
The price is $450 total per night from Mar 12 to Mar 13
$450 total
Mar 12 - Mar 13
Total with taxes and fees
9/10 Wonderful! (26 reviews)
The resort is an experience. The staff were helpful and genuine.

Reviewed on Nov 9, 2025

The Lodge at Primland, Auberge Collection
Hotel Floyd

Hotel Floyd

2 out of 5
300 Rick Lewis Way Floyd VA
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Feb 12 to Feb 13
$121 total
Feb 12 - Feb 13
Total with taxes and fees
9.6/10 Exceptional! (493 reviews)
Clean, polite and helpful staff.

Reviewed on Dec 6, 2025

Hotel Floyd
Comfort Inn Martinsville

Comfort Inn Martinsville

3 out of 5
378 Commonwealth Blvd W Martinsville VA
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $118 total per night from Feb 22 to Feb 23
$118 total
Feb 22 - Feb 23
Total with taxes and fees
6.8/10 (628 reviews)
Hotel was clean room was nice and smelt clean. Wake up call service was having a problem unable to use that service and the front door was having an issue, but the hotel was clean, and the breakfast was good

Reviewed on Jan 23, 2026

Comfort Inn Martinsville
See all 270 properties in Mayo River
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mayo River Vacation Packages

Mayo River Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Piedmont Triad Intl. Airport (GSO)

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Mayo River vacation package cost?
You'll find cheap prices from $460 on Expedia for your Mayo River getaway. However, a range of factors like the season, choice of hotel and length of stay will determine how much your vacation to Mayo River costs.
What are the cheapest months to go to Mayo River?
March, August and December are the best times to look for cheap Mayo River vacation packages. Choosing to travel in quieter periods means you'll typically find lower prices on flights and hotels.
How many days is enough for Mayo River?
Typically, a handful of days is enough to explore the top sights during your Mayo River vacation. However, if you prefer to have more time to chill out or go on day tours, consider extending your itinerary.
How to find the best Mayo River package deals?
Bagging a cheap Mayo River package deal is easy with Expedia. After you've entered your destination and trip dates under our "Packages" tab, set your maximum budget, add some filters and see what's available. You can personalize your search by "Amenities," "Property type," "Popular locations" and more. Order the results by "Price: low to high" to discover the most wallet-friendly Mayo River package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Mayo River vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll generally land a better deal than booking each component separately. And you'll still get the freedom to create a customized Mayo River vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Mayo River?
Secure incredible bargains by reserving your flights ahead of time with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment Mayo River adventure.
How to plan a trip to Mayo River?

  1. Choose when to travel: Check your schedule and pack your bags. Your favorite time of year and the type of activities available will also help you decide when to visit Mayo River.
  2. Calculate your budget: Ensure you have enough money to cover everything from transportation and meals to experiences and flights. Your accommodations will likely be the biggest expense during your trip to Mayo River.
  3. Use our trip planning tool to discover Mayo River: Research every part of your trip to Mayo River with this handy planner. Invite your family and friends to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Set the duration of your trip: Start by listing all the attractions you'd like to experience in Mayo River. Then, estimate how long you'll need at each, as well as any travel time.
  5. Bundle your bookings: With your travel dates in order, you can combine your hotels, car rental, flights and more into a customized Mayo River vacation package.
  6. Add on excursions and experiences: Have a look at our dedicated travel guide to find some exciting things to do in Mayo River. Book tickets or make reservations as soon as you can to save time and skip the hassle of looking for activities once you arrive.

Does Expedia offer Book Now, Pay Later Mayo River vacation packages?
Set off on your dream escape to Mayo River with our Book Now, Pay Later vacations. No need to save like crazy or wait until the next payday — we've teamed up with online lender Affirm to give you more financial flexibility. Our vacation packages with payment plans allow you to spread the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, you can easily stay on budget and snap up travel deals while they last.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.