Mayo River Vacations from $518

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Mayo River vacation packages

Price found within the past 48 hours. Click for updated prices.
Comfort Inn Greensboro - Kernersville

Comfort Inn Greensboro - Kernersville

2.5 out of 5
Price was $585, price is now $518 per person
$518
per person
Apr 9 - Apr 13
found 24 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Greensboro (GSO)
8.4/10 Very Good! (1,001 reviews)
Courteous staff- the rooms are less then impressive- bathroom was terrible- tiles falling off and drain completely backed up-

Reviewed on Feb 16, 2026

The Historic Magnolia House

The Historic Magnolia House

3.5 out of 5
Price was $826, price is now $653 per person
$653
per person
Apr 9 - Apr 13
found 24 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Greensboro (GSO)
6/10 (2 reviews)
Comfort Suites Greensboro - High Point

Comfort Suites Greensboro - High Point

2.5 out of 5
Price was $684, price is now $593 per person
$593
per person
Apr 9 - Apr 13
found 24 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Greensboro (GSO)
8.8/10 Excellent! (653 reviews)
Hotel smelled amazing. Shower walls weren’t clean. They had shampoo or conditioner still on the wall. The blue color matched the hotel supplied product. The mirror was also smeared and dirty. Doors slam in the hallway constantly also

Reviewed on Feb 9, 2026

O.Henry Hotel

O.Henry Hotel

4 out of 5
Price was $683, price is now $598 per person
$598
per person
Mar 27 - Mar 29
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Greensboro (GSO)
9.8/10 Exceptional! (724 reviews)
The room was beautifully appointed and perfectly clean. It was absolutely quiet, allowing us a wonderful night's sleep. The staff was friendly and helpful.

Reviewed on Feb 11, 2026

Greenwood Bed & Breakfast

Greenwood Bed & Breakfast

3 out of 5
Fisher Park
Price was $723, price is now $652 per person
$652
per person
Apr 9 - Apr 13
found 24 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Greensboro (GSO)
9.4/10 Exceptional! (52 reviews)
Quiet neighborhood. Nice 120 year old home. Very pleasant and responsive host. Parking directly across the street. Breakfast was delicious and plentiful. Even brought home a couple of freshly picked Japanese Persimmon fruit. Would stay again.

Reviewed on Oct 12, 2025

Don't see what you're looking for?
See all available trips from Columbus to Mayo River
View all trips

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.
Book now

Discover the most popular places to visit in Mayo River

The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.

Reynolds Homestead

You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas.

Reynolds Homestead

Mayo River Hotel Deals

The Lodge at Primland, Auberge Collection

The Lodge at Primland, Auberge Collection

5 out of 5
2000 Busted Rock Rd Meadows Of Dan VA
$463 nightly
The price is $520 total per night from Mar 2 to Mar 3
$520 total
Mar 2 - Mar 3
Total with taxes and fees
The Lodge at Primland, Auberge Collection
Hampton Inn Eden

Hampton Inn Eden

2.5 out of 5
724 S Van Buren Rd Eden NC
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $128 total per night from Feb 28 to Mar 1
$128 total
Feb 28 - Mar 1
Total with taxes and fees
8.6/10 Excellent! (441 reviews)
Everything was good

Reviewed on Feb 17, 2026

Hampton Inn Eden
Hotel Floyd

Hotel Floyd

2 out of 5
300 Rick Lewis Way Floyd VA
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Feb 18 to Feb 19
$121 total
Feb 18 - Feb 19
Total with taxes and fees
9.6/10 Exceptional! (495 reviews)
Room was very nice! We had a wonderful Valentine stay ♥️. We have stayed one other time and has not disappointed. The continental breakfast is wonderful. We will stay again!

Reviewed on Feb 15, 2026

Hotel Floyd
See all 268 properties in Mayo River
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mayo River Vacation Packages

Mayo River Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Piedmont Triad Intl. Airport (GSO)

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Mayo River vacation package cost?
You'll find cheap prices from $518 on Expedia for your Mayo River getaway. However, a range of factors like the season, choice of hotel and length of stay will determine how much your vacation to Mayo River costs.
What are the cheapest months to go to Mayo River?
March, August and December are the best times to look for cheap Mayo River vacation packages. Choosing to travel in quieter periods means you'll typically find lower prices on flights and hotels.
How many days is enough for Mayo River?
Typically, a handful of days is enough to explore the top sights during your Mayo River vacation. However, if you prefer to have more time to chill out or go on day tours, consider extending your itinerary.
How to find the best Mayo River package deals?
Bagging a cheap Mayo River package deal is easy with Expedia. After you've entered your destination and trip dates under our "Packages" tab, set your maximum budget, add some filters and see what's available. You can personalize your search by "Amenities," "Property type," "Popular locations" and more. Order the results by "Price: low to high" to discover the most wallet-friendly Mayo River package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Mayo River vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll generally land a better deal than booking each component separately. And you'll still get the freedom to create a customized Mayo River vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Mayo River?
Secure incredible bargains by reserving your flights ahead of time with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment Mayo River adventure.
How to plan a trip to Mayo River?

  1. Choose when to travel: Check your schedule and pack your bags. Your favorite time of year and the type of activities available will also help you decide when to visit Mayo River.
  2. Calculate your budget: Ensure you have enough money to cover everything from transportation and meals to experiences and flights. Your accommodations will likely be the biggest expense during your trip to Mayo River.
  3. Use our trip planning tool to discover Mayo River: Research every part of your trip to Mayo River with this handy planner. Invite your family and friends to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Set the duration of your trip: Start by listing all the attractions you'd like to experience in Mayo River. Then, estimate how long you'll need at each, as well as any travel time.
  5. Bundle your bookings: With your travel dates in order, you can combine your hotels, car rental, flights and more into a customized Mayo River vacation package.
  6. Add on excursions and experiences: Have a look at our dedicated travel guide to find some exciting things to do in Mayo River. Book tickets or make reservations as soon as you can to save time and skip the hassle of looking for activities once you arrive.

Does Expedia offer Book Now, Pay Later Mayo River vacation packages?
Set off on your dream escape to Mayo River with our Book Now, Pay Later vacations. No need to save like crazy or wait until the next payday — we've teamed up with online lender Affirm to give you more financial flexibility. Our vacation packages with payment plans allow you to spread the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, you can easily stay on budget and snap up travel deals while they last.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.