Mayo River Vacations from $339

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The Latest Mayo River vacation packages

Price found within the past 48 hours. Click for updated prices.
Dailey Renewal Retreat Bed & Breakfast

Dailey Renewal Retreat Bed & Breakfast

3 out of 5
Lindley Park
Price was $403, price is now $339 per person
$339
per person
Mar 20 - Mar 22
found 9 hours ago
Roundtrip flight included
New York (LGA) to Greensboro (GSO)
9/10 Wonderful! (207 reviews)
This place will always be near and dear to my heart. The breakfast was absolutely delicious, the atmosphere was so cozy and loving I did not want to leave. It was a pleasure to meet Miss Jean Dailey and I hope to come back some time soon. Plus, the house is surrounded by some VERY delicious options for food. If you’re looking for a home-away-from-home getaway, that actually isn’t in the middle of nowhere, I highly recommend!

Reviewed on Aug 5, 2025

The Historic Magnolia House

The Historic Magnolia House

3.5 out of 5
Price was $476, price is now $393 per person
$393
per person
Mar 20 - Mar 22
found 9 hours ago
Roundtrip flight included
New York (LGA) to Greensboro (GSO)
6/10 (2 reviews)
King Beds Hot Tub Arcade Grill & Firepit

King Beds Hot Tub Arcade Grill & Firepit

4 out of 5
Price was $869, price is now $721 per person
$721
per person
Mar 20 - Mar 22
found 9 hours ago
Roundtrip flight included
New York (LGA) to Greensboro (GSO)
8/10 Very Good! (1 review)
Townhouse Winston Salem - University

Townhouse Winston Salem - University

2.5 out of 5
Price was $491, price is now $410 per person
$410
per person
Apr 8 - Apr 13
found 17 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
5.6/10 (965 reviews)
Check in was easy. Staff was friendly, heating and air was good in the room.

Reviewed on Dec 28, 2025

La Quinta Inn & Suites by Wyndham Winston-Salem

La Quinta Inn & Suites by Wyndham Winston-Salem

3 out of 5
Price was $552, price is now $466 per person
$466
per person
Apr 24 - Apr 27
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Greensboro (GSO)
7/10 Good! (1,004 reviews)
Room was clean. Beds were comfortable. Staff was nice. Disappointed that by 9 am there was nothing left for breakfast. The Village Tavern was a wonderful food and atmosphere experience!!

Reviewed on Jan 30, 2026

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Discover the most popular places to visit in Mayo River

The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.

Reynolds Homestead

You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas.

Reynolds Homestead

Mayo River Hotel Deals

The Lodge at Primland, Auberge Collection

The Lodge at Primland, Auberge Collection

5 out of 5
2000 Busted Rock Rd Meadows Of Dan VA
$440 nightly
The price is $494 total per night from Mar 15 to Mar 16
$494 total
Mar 15 - Mar 16
Total with taxes and fees
9/10 Wonderful! (26 reviews)
The resort is an experience. The staff were helpful and genuine.

Reviewed on Nov 9, 2025

The Lodge at Primland, Auberge Collection
Hotel Floyd

Hotel Floyd

2 out of 5
300 Rick Lewis Way Floyd VA
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Feb 15 to Feb 16
$121 total
Feb 15 - Feb 16
Total with taxes and fees
9.6/10 Exceptional! (493 reviews)
Clean, polite and helpful staff.

Reviewed on Dec 6, 2025

Hotel Floyd
Comfort Inn Martinsville

Comfort Inn Martinsville

3 out of 5
378 Commonwealth Blvd W Martinsville VA
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $120 total per night from Feb 22 to Feb 23
$120 total
Feb 22 - Feb 23
Total with taxes and fees
6.8/10 (628 reviews)
Hotel was clean room was nice and smelt clean. Wake up call service was having a problem unable to use that service and the front door was having an issue, but the hotel was clean, and the breakfast was good

Reviewed on Jan 23, 2026

Comfort Inn Martinsville
See all 270 properties in Mayo River
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mayo River Vacation Packages

Mayo River Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Piedmont Triad Intl. Airport (GSO)

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Frequently asked questions

How much does a Mayo River vacation package cost?
You'll find cheap prices from $339 on Expedia for your Mayo River getaway. However, a range of factors like the season, choice of hotel and length of stay will determine how much your vacation to Mayo River costs.
What are the cheapest months to go to Mayo River?
March, August and December are the best times to look for cheap Mayo River vacation packages. Choosing to travel in quieter periods means you'll typically find lower prices on flights and hotels.
How many days is enough for Mayo River?
Typically, a handful of days is enough to explore the top sights during your Mayo River vacation. However, if you prefer to have more time to chill out or go on day tours, consider extending your itinerary.
How to find the best Mayo River package deals?
Bagging a cheap Mayo River package deal is easy with Expedia. After you've entered your destination and trip dates under our "Packages" tab, set your maximum budget, add some filters and see what's available. You can personalize your search by "Amenities," "Property type," "Popular locations" and more. Order the results by "Price: low to high" to discover the most wallet-friendly Mayo River package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Mayo River vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll generally land a better deal than booking each component separately. And you'll still get the freedom to create a customized Mayo River vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Mayo River?
Secure incredible bargains by reserving your flights ahead of time with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment Mayo River adventure.
How to plan a trip to Mayo River?

  1. Choose when to travel: Check your schedule and pack your bags. Your favorite time of year and the type of activities available will also help you decide when to visit Mayo River.
  2. Calculate your budget: Ensure you have enough money to cover everything from transportation and meals to experiences and flights. Your accommodations will likely be the biggest expense during your trip to Mayo River.
  3. Use our trip planning tool to discover Mayo River: Research every part of your trip to Mayo River with this handy planner. Invite your family and friends to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Set the duration of your trip: Start by listing all the attractions you'd like to experience in Mayo River. Then, estimate how long you'll need at each, as well as any travel time.
  5. Bundle your bookings: With your travel dates in order, you can combine your hotels, car rental, flights and more into a customized Mayo River vacation package.
  6. Add on excursions and experiences: Have a look at our dedicated travel guide to find some exciting things to do in Mayo River. Book tickets or make reservations as soon as you can to save time and skip the hassle of looking for activities once you arrive.

Does Expedia offer Book Now, Pay Later Mayo River vacation packages?
Set off on your dream escape to Mayo River with our Book Now, Pay Later vacations. No need to save like crazy or wait until the next payday — we've teamed up with online lender Affirm to give you more financial flexibility. Our vacation packages with payment plans allow you to spread the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, you can easily stay on budget and snap up travel deals while they last.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.