Title: Mayo River Vacation Packages 2026 from $364 | Expedia.com [Mayo River Travel Guide](https://expedia.com/Mayo-River.dx553248635976006279)[Hotels in Mayo River](https://expedia.com/Mayo-River-Hotels.d553248635976006279.Travel-Guide-Hotels)[Vacation Rentals in Mayo River](https://expedia.com/Mayo-River-Vacation-Rentals.d553248635976006279.Travel-Guide-VacationRentals)[Flights to Mayo River](https://expedia.com/Cheap-Flights-To-Mayo-River.d553248635976006279.Travel-Guide-Flights)[Car Rentals in Mayo River](https://expedia.com/Car-Rentals-In-Mayo-River.d553248635976006279.Car-Rental-Guide) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Mayo River Vacations from $364 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## The Latest Mayo River vacation packages Price found within the past 48 hours. Click for updated prices. ![Quality Inn & Suites Thomasville-High Point](https://images.trvl-media.com/lodging/1000000/160000/154600/154562/32944001_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Quality Inn & Suites Thomasville-High Point $364 per person Jun 10 - Jun 14 found 1 day ago Roundtrip flight included New York (LGA) to Greensboro (GSO) 7/10 Good! (105 reviews) Clean rooms and friendly staff Reviewed on Dec 25, 2025 ![Arcade Kid Friendly Firepit Grill HotTub](https://images.trvl-media.com/lodging/113000000/112790000/112784800/112784705/2693b6fb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Arcade Kid Friendly Firepit Grill HotTub Save 100% on your flight $1,707 per person May 28 - May 31 found 1 day ago Roundtrip flight included New York (NYC) to Greensboro (GSO) No reviews ![O.Henry Hotel](https://images.trvl-media.com/lodging/1000000/210000/200700/200643/780513c5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### O.Henry Hotel $540 per person May 15 - May 17 found 23 hours ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Greensboro (GSO) 9.8/10 Exceptional! (776 reviews) Our favorite hotel - always wonderful and always consistent - the friendliest, most accommodating staff and lots of places to relax Reviewed on Apr 5, 2026 ![Proximity Hotel](https://images.trvl-media.com/lodging/2000000/1730000/1725300/1725222/6110fc6d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Proximity Hotel $537 per person May 15 - May 17 found 23 hours ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Greensboro (GSO) 9.8/10 Exceptional! (975 reviews) This establishment is the best in the city. Me and my family enjoy it so much, it’s our third time staying there. I hope to soon do a honeymoon weekend that they offer. Reviewed on Apr 5, 2026 ![The Historic Magnolia House](https://images.trvl-media.com/lodging/73000000/72470000/72464600/72464524/2b9b9b34_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Historic Magnolia House $539 per person Jun 18 - Jun 20 found 24 hours ago Roundtrip non-stop flight included Houston (IAH) to Greensboro (GSO) 6/10 (2 reviews) Don't see what you're looking for? See all available trips from Columbus to Mayo River [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-05-08/2026-05-15/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GSO&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ### Discover the most popular places to visit in Mayo River ![Reynolds Homestead](https://images.trvl-media.com/place/553248621561864249/54558157-d5bc-4ba5-a77d-f9a917492c5a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Reynolds Homestead You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas. [](https://expedia.com/Reynolds-Homestead-Patrick-Springs.d553248621561864249.Vacation-Attraction) ## Mayo River Hotel Deals ![The Lodge at Primland, Auberge Collection](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/96761cd0_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Lodge at Primland, Auberge Collection 2000 Busted Rock Rd Meadows Of Dan VA $737 nightly $827 total May 3 - May 4 Total with taxes and fees 9/10 Wonderful! (31 reviews) Star gazing & wine tasting was amazing! Staff extremely helpful. Excellent food. Check into the activities available for each day of your stay BEFORE you get there. Book early since the number of people for each activity can be limited. Some activities only available certain days. Reviewed on Mar 21, 2026 [](https://expedia.com/Hotel-Search?startDate=5%2F3%2F2026&endDate=5%2F4%2F2026&selected=3633184&PinnedHotelID=3633184&HadPinnedHotel=true®ionId=553248635976006279) ![Comfort Inn Martinsville](https://images.trvl-media.com/lodging/1000000/670000/665100/665072/012d74f6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfort Inn Martinsville 378 Commonwealth Blvd W Martinsville VA Fully refundable $119 nightly $133 total May 3 - May 4 Total with taxes and fees 6.8/10 (640 reviews) Breakfast was lousy. Otherwise, staff was very friendly and efficient. Would go there again. Reviewed on Apr 5, 2026 [](https://expedia.com/Hotel-Search?startDate=5%2F3%2F2026&endDate=5%2F4%2F2026&selected=665072&PinnedHotelID=665072&HadPinnedHotel=true®ionId=553248635976006279) ![Hotel Floyd](https://images.trvl-media.com/lodging/9000000/8990000/8986900/8986854/e5c62df7_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Floyd 300 Rick Lewis Way Floyd VA Fully refundableReserve now, pay when you stay $121 nightly $133 total Apr 12 - Apr 13 Total with taxes and fees 9.6/10 Exceptional! (504 reviews) The room was clean, eclectic, had some older features, like mattress, bathroom fixtures, but it had a homey feel with interesting furniture pieces. Very comfortable. Reviewed on Apr 4, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=8986854&PinnedHotelID=8986854&HadPinnedHotel=true®ionId=553248635976006279) [See all 267 properties in Mayo River](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=4%2F9%2F2026&endDate=4%2F10%2F2026®ionId=553248635976006279) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Mayo River Vacation Packages ## Mayo River Essential Information | Language | English | | --------------- | ---------------------------------- | | Currency | U.S dollars | | Closest Airport | Piedmont Triad Intl. Airport (GSO) | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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Choose when to travel: Check your schedule and pack your bags. Your favorite time of year and the type of activities available will also help you decide when to visit Mayo River. > 2. Calculate your budget: Ensure you have enough money to cover everything from transportation and meals to experiences and flights. Your accommodations will likely be the biggest expense during your trip to Mayo River. > 3. Use our [trip planning tool](https://www.expedia.com/why/trip-planning) to discover Mayo River: Research every part of your trip to Mayo River with this handy planner. Invite your family and friends to collaborate on a group trip, search for hotels or things to do and make bookings. > 4. Set the duration of your trip: Start by listing all the attractions you'd like to experience in Mayo River. Then, estimate how long you'll need at each, as well as any travel time. > 5. Bundle your bookings: With your travel dates in order, you can combine your hotels, car rental, flights and more into a customized Mayo River vacation package. > 6. Add on excursions and experiences: Have a look at our dedicated travel guide to find some exciting [things to do](https://www.expedia.com/Activities) in Mayo River. Book tickets or make reservations as soon as you can to save time and skip the hassle of looking for activities once you arrive. ### Does Expedia offer Book Now, Pay Later Mayo River vacation packages? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Critz Hotels ](https://www.expedia.com/Critz-Hotels.d6351114.Travel-Guide-Hotels) - [Cabin Rentals in Critz ](https://www.expedia.com/Critz-Cabins.d6351114-aaCabins.Travel-Guide-Accommodation) - [B&B in Critz ](https://www.expedia.com/Critz-Bed-And-Breakfast.d6351114-aaBedAndBreakfast.Travel-Guide-Accommodation) - [3 Star Hotels in Critz ](https://www.expedia.com/3Star-Critz-Hotels.s30-0-d6351114.Travel-Guide-Filter-Hotels) - [Vacation Homes in Critz ](https://www.expedia.com/Critz-Private-Vacation-Homes.d6351114-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Patrick Springs Hotels ](https://www.expedia.com/Patrick-Springs-Hotels.d3000460602.Travel-Guide-Hotels) - [Cabin Rentals in Patrick Springs ](https://www.expedia.com/Patrick-Springs-Cabins.d3000460602-aaCabins.Travel-Guide-Accommodation) - 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