COVID-19 alert: Travel requirements are changing rapidly, including need for pre-travel COVID-19 testing and quarantine on arrival.

Top Hotels Near Mississippi River in United States of America

Search over 1 million properties and 550 airlines worldwide.

Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.

Free cancellation on most hotels. Because flexibility matters.

Top Hotels Close to Mississippi River

Marriott St. Louis Grand
4 out of 5
62 mi from Mississippi River
Free CancellationReserve now, pay when you stay
The price is $143 per night from May 27 to May 27
4.2/5Excellent! (987 reviews)
"Perfect accommodations. Friendly staff. Helpful"

Reviewed on May 3, 2021

Marriott St. Louis Grand
Le Méridien St. Louis Clayton
4 out of 5
58 mi from Mississippi River
Free CancellationReserve now, pay when you stay
The price is $149 per night from May 31 to May 31
4.4/5Excellent! (81 reviews)
"It was a clean and nice place"

Reviewed on May 3, 2021

Le Méridien St. Louis Clayton
Pear Tree Inn St. Louis Airport
2.5 out of 5
61 mi from Mississippi River
Free CancellationReserve now, pay when you stay
The price is $76 per night from May 16 to May 16
4.4/5Excellent! (1,297 reviews)
"Very friendly staff! I felt welcome and jot just like another customer."

Reviewed on May 9, 2021

Pear Tree Inn St. Louis Airport
You could be seeing lower prices

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 out of 5
58 mi from Mississippi River
Free CancellationReserve now, pay when you stay
The price is $58 per night from May 11 to May 11
3.5/5Good! (963 reviews)
"Convenient, affordable and great location. I was comfortable. Thanks"

Reviewed on May 6, 2021

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Beautiful 2 Bedroom Unit at Resort, Sleeps 6
Drury Inn & Suites Southwest St. Louis
3 out of 5
48 mi from Mississippi River
Free CancellationReserve now, pay when you stay
The price is $90 per night from May 16 to May 16
4.6/5Exceptional! (970 reviews)
"Clean room."

Reviewed on May 9, 2021

Drury Inn & Suites Southwest St. Louis
Drury Plaza Hotel St. Louis at the Arch
3 out of 5
61 mi from Mississippi River
Free CancellationReserve now, pay when you stay
The price is $126 per night from May 16 to May 16
4.6/5Exceptional! (1,832 reviews)
"The whole hotel was clean, and the staff was extremely helpful and friendly. I’ll definitely be staying again."

Reviewed on May 7, 2021

Drury Plaza Hotel St. Louis at the Arch
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
2.5 out of 5
38 mi from Mississippi River
Free CancellationReserve now, pay when you stay
The price is $84 per night from May 16 to May 16
4.1/5Very Good! (301 reviews)
"The rooms were very clean, the hotel itself was very nice."

Reviewed on Apr 26, 2021

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Live by Loews - St.Louis
3.5 out of 5
61 mi from Mississippi River
Free CancellationReserve now, pay when you stay
The price is $139 per night from May 10 to May 10
4.7/5Exceptional! (144 reviews)
"Great service"

Reviewed on May 3, 2021

Live by Loews - St.Louis
River City Casino & Hotel
4 out of 5
55 mi from Mississippi River
Free CancellationReserve now, pay when you stay
The price is $110 per night from May 17 to May 17
4.4/5Wonderful! (977 reviews)
"*"

Reviewed on Apr 27, 2021

River City Casino & Hotel
Don't see what you're looking for?
See all available properties in Mississippi River
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.